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B-1a B Cells Regulate T Cell Differentiation Associated with Pregnancy Disturbances
- During pregnancy, the maternal immune system faces a double dilemma: tolerate the growing semi-allogeneic fetus and at the same time protect the mother and the progeny against pathogens. This requires a fine and extremely regulated equilibrium between immune activation and tolerance. As professional antigen presenting cells, B cells and in particular B-1a B cells, can activate or tolerize T cells and thus participate in the generation or regulation of the immune response. B-1a B cells were involved in the humoral immune response leading to pre-eclampsia, one of the main medical complications during pregnancy. Here we demonstrated that B-1a B cells are additionally involved in cellular immune mechanisms associated with pregnancy complications. Using a mouse model of pregnancy disturbances, we showed that B-1a B cells from animals suffering pregnancy disturbances but not from those developing normal pregnancies induce the differentiation of naïve T cells into Th17 and Th1 cells. This differential role of B-1a B cells during pregnancy seems to be associated with the co-stimulatory molecule CD86 as normal pregnant mice showed lower percentages of CD86 expressing B-1a B cells as compared to pregnant mice developing pregnancy disturbances or to non-pregnant animals. Our data bring to light a new and not explored role of B-1a B cells in the context of pregnancy.
Author: | Damián Oscar Muzzio, Rocío Soldati, Luise Rolle, Marek Zygmunt, Ana Claudia Zenclussen, Federico Jensen |
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URN: | urn:nbn:de:gbv:9-opus-32195 |
DOI: | https://doi.org/https://doi.org/10.3389/fimmu.2014.00006 |
ISSN: | 1664-3224 |
Parent Title (English): | Frontiers in Immunology |
Publisher: | Frontiers Media S.A. |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2014/01/21 |
Release Date: | 2022/05/09 |
Tag: | B-1a B cells; Th1; Th17; pregnancy; tolerance |
GND Keyword: | - |
Volume: | 5 |
Article Number: | 6 |
Page Number: | 8 |
Faculties: | Universitätsmedizin / Klinik und Poliklinik für Frauenheilkunde u. Geburtshilfe |
Licence (German): | Creative Commons - Namensnennung |