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Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-32195

B-1a B Cells Regulate T Cell Differentiation Associated with Pregnancy Disturbances

  • During pregnancy, the maternal immune system faces a double dilemma: tolerate the growing semi-allogeneic fetus and at the same time protect the mother and the progeny against pathogens. This requires a fine and extremely regulated equilibrium between immune activation and tolerance. As professional antigen presenting cells, B cells and in particular B-1a B cells, can activate or tolerize T cells and thus participate in the generation or regulation of the immune response. B-1a B cells were involved in the humoral immune response leading to pre-eclampsia, one of the main medical complications during pregnancy. Here we demonstrated that B-1a B cells are additionally involved in cellular immune mechanisms associated with pregnancy complications. Using a mouse model of pregnancy disturbances, we showed that B-1a B cells from animals suffering pregnancy disturbances but not from those developing normal pregnancies induce the differentiation of naïve T cells into Th17 and Th1 cells. This differential role of B-1a B cells during pregnancy seems to be associated with the co-stimulatory molecule CD86 as normal pregnant mice showed lower percentages of CD86 expressing B-1a B cells as compared to pregnant mice developing pregnancy disturbances or to non-pregnant animals. Our data bring to light a new and not explored role of B-1a B cells in the context of pregnancy.

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Metadaten
Author: Damián Oscar Muzzio, Rocío Soldati, Luise Rolle, Marek Zygmunt, Ana Claudia Zenclussen, Federico Jensen
URN:urn:nbn:de:gbv:9-opus-32195
DOI:https://doi.org/https://doi.org/10.3389/fimmu.2014.00006
ISSN:1664-3224
Parent Title (English):Frontiers in Immunology
Publisher:Frontiers Media S.A.
Document Type:Article
Language:English
Date of first Publication:2014/01/21
Release Date:2022/05/09
Tag:B-1a B cells; Th1; Th17; pregnancy; tolerance
GND Keyword:-
Volume:5
Article Number:6
Page Number:8
Faculties:Universitätsmedizin / Klinik und Poliklinik für Frauenheilkunde u. Geburtshilfe
Licence (German):License LogoCreative Commons - Namensnennung