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Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-39917

Three‐liquid‐phase Spinning Reactor for the Transaminase‐catalyzed Synthesis and Recovery of a Chiral Amine

  • Abstract A device for the transaminase‐catalysed synthesis combined with continuous recovery of chiral amines was designed. The system enabled the separation of the reaction components in three liquid phases: a reaction phase, an organic solvent phase (where the poorly water soluble ketone substrate was supplied), and an aqueous extraction phase for continuous product recovery. The transaminase‐mediated asymmetric synthesis of (S)‐1‐methyl‐3‐phenylpropylamine was employed as model reaction. Factors influencing the performance of the system, such as reactor geometry, working volumes and operating parameters, were investigated. Specifically, reaction yield and product recovery were enhanced by i) reducing the thickness of the reaction phase, while continuously stirring and ii) reducing the volume of the extraction phase. Under the optimal condition tested, 85 % of the product formed was extracted and a product concentration value of 9 g/L was reached. However, co‐extraction of the unreacted amine donor (17 %) was observed. Advantages and drawbacks of this process compared to existing technologies, as well as possible optimization strategies are discussed.

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Metadaten
Author: Claudia Matassa, Dominic Ormerod, Uwe T. Bornscheuer, Matthias Höhne, Yamini Satyawali
URN:urn:nbn:de:gbv:9-opus-39917
DOI:https://doi.org/10.1002/cctc.201902056
Parent Title (English):ChemCatChem
Publisher:Wiley
Place of publication:Hoboken, New Jersey
Document Type:Article
Language:English
Date of first Publication:2020/03/06
Release Date:2020/12/01
Tag:Chiral amines; asymmetric synthesis; biocatalysis; liquid-liquid extraction; transaminases
GND Keyword:-
Volume:12
Issue:5
First Page:1288
Last Page:1291
Faculties:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie und Biochemie
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell