Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-75414
Preparation of Solid Self-Nanoemulsifying Drug Delivery Systems (S-SNEDDS) by Co-Extrusion of Liquid SNEDDS and Polymeric Carriers—A New and Promising Formulation Approach to Improve the Solubility of Poorly Water-Soluble Drugs
- The present study focused on a new formulation approach to improving the solubility of drugs with poor aqueous solubility. A hot melt extrusion (HME) process was applied to prepare drug-loaded solid self-nanoemulsifying drug delivery systems (S-SNEDDS) by co-extrusion of liquid SNEDDS (L-SNEDDS) and different polymeric carriers. Experiments were performed with L-SNEDDS formulations containing celecoxib, efavirenz or fenofibrate as model drugs. A major objective was to identify a polymeric carrier and process parameters that would enable the preparation of stable S-SNEDDS without impairing the release behavior and storage stability of the L-SNEDDS used and, if possible, even improving them further. In addition to commercially available (co)polymers already used in the field of HME, a particular focus was on the evaluation of different variants of a recently developed aminomethacrylate-based copolymer (ModE) that differed in Mw. Immediately after preparation, the L-SNEDDS and S-SNEDDS formulations were tested for amorphicity by differential scanning calorimetry. Furthermore, solubility and dissolution tests were performed. In addition, the storage stability was investigated at 30 °C/65% RH over a period of three and six months, respectively. In all cases, amorphous formulations were obtained and, especially for the model drug celecoxib, S-SNEDDS were developed that maintained the rapid and complete drug release of the underlying L-SNEDDS even over an extended storage period. Overall, the data obtained in this study suggest that the presented S-SNEDDS approach is very promising, provided that drug-loaded L-SNEDDS are co-processed with a suitable polymeric carrier. In the case of celecoxib, the E-173 variant of the novel ModE copolymer proved to be a novel polymeric carrier with great potential for application in S-SNEDDS. The presented approach will, therefore, be pursued in future studies to establish S-SNEDDS as an alternative formulation to other amorphous systems.
Author: | Fabian-Pascal Schmied, Alexander Bernhardt, Sandra Klein |
---|---|
URN: | urn:nbn:de:gbv:9-opus-75414 |
DOI: | https://doi.org/10.3390/ph15091135 |
ISSN: | 1424-8247 |
Parent Title (English): | Pharmaceuticals |
Publisher: | MDPI |
Place of publication: | Basel |
Editor: | María Ángeles Peña Fernández |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2022/09/11 |
Release Date: | 2022/11/14 |
Tag: | amorphous formulations; celecoxib; copolymer; drug release; efavirenz; fenofibrate; hot melt extrusion; nanoemulsion; poorly soluble drug |
GND Keyword: | - |
Volume: | 15 |
Issue: | 9 |
Article Number: | 1135 |
Page Number: | 20 |
Faculties: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Pharmazie |
Licence (German): | Creative Commons - Namensnennung |