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Enzyme Kits to Facilitate the Integration of Biocatalysis into Organic Chemistry – First Aid for Synthetic Chemists
- Abstract First Aid Kits are collections of the most important medical equipment required for quick medical assistance. Similarly, enzyme kits can provide a proficient, ready‐ and easy‐to‐use collection of biocatalysts that can be applied with high reproducibility. In this article, we illustrate how kits of oxyfunctionalisation enzymes could operate as synthetic ‘First Aid’ for chemists working on complex natural product total synthesis in an early‐ or late‐stage fashion, as well as in lead diversification in drug discovery processes. We reason that enzyme kits could catalyse the integration of biocatalysis into (synthetic) organic chemistry and describe how we envision their future application.
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| Author: | Nico D. Fessner, Christoffel P. S. Badenhorst, Uwe T. BornscheuerORCiD |
|---|---|
| URN: | urn:nbn:de:gbv:9-opus-74841 |
| DOI: | https://doi.org/https://doi.org/10.1002/cctc.202200156 |
| ISSN: | 1867-3899 |
| Parent Title (English): | ChemCatChem |
| Publisher: | Wiley |
| Place of publication: | Hoboken, NJ |
| Document Type: | Article |
| Language: | English |
| Date of first Publication: | 2022/04/21 |
| Release Date: | 2022/11/29 |
| Tag: | biocatalysis; early-stage functionalisation; enzyme kits; late-stage functionalisation; lead diversification |
| Volume: | 14 |
| Issue: | 11 |
| Article Number: | e2022001 |
| Page Number: | 10 |
| Faculties: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung |