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A Biocatalytic Cascade Reaction to Access a Valuable Long‐Chain ω‐Hydroxy Fatty Acid
- Abstract Environmentally‐friendly processes for the manufacturing of valuable industrial compounds like ω‐hydroxy fatty acids (ω‐OHFAs) are highly desirable. Herein, we present such an approach by establishing a two‐step enzymatic cascade reaction for the production of 2,15,16‐trihydroxy hexadecanoic acid (THA). Starting with the easily accessible natural compound ustilagic acid (UA) that is secreted by the corn smut fungus Ustilago maydis, the recombinantly expressed esterase BS2 from Bacillus subtilis and the commercial β‐glucosidase from almonds were applied yielding 86 % product. Both hydrolases do not require expensive cofactors, making the process economically attractive. Additionally, no harmful solvents are required, so that the product THA can be labelled natural to be used in food and cosmetic products.
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| Author: | Aileen Becker, Dominique Böttcher, Werner Katzer, Karsten Siems, Lutz Müller‐Kuhrt, Uwe T. Bornscheuer |
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| URN: | urn:nbn:de:gbv:9-opus-41538 |
| DOI: | https://doi.org/10.1002/cctc.202000745 |
| Parent Title (English): | ChemCatChem |
| Document Type: | Article |
| Language: | English |
| Date of first Publication: | 2020/08/21 |
| Release Date: | 2021/02/05 |
| Tag: | biocatalysis; cascade reaction; natural products; ustilagic acid; ω-hydroxy fatty acid |
| GND Keyword: | - |
| Volume: | 12 |
| Issue: | 16 |
| First Page: | 4084 |
| Last Page: | 4089 |
| Faculties: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung |