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Local Epidemiology of Nosocomial Staphylococcus aureus Infection in a Nigerian University Teaching Hospital
- Population-based studies of Staphylococcus aureus contribute to understanding the epidemiology of S. aureus infection. We enrolled surgical inpatients admitted to an African tertiary-care hospital in order to prospectively analyze the nosocomial impact of S. aureus. Data collection included an active sampling of the anterior nares and infectious foci within 48 h after admission and subsequently when clinically indicated. All S. aureus isolates were spa and agr genotyped. Possession of Panton-Valentine leukocidin (PVL) and other toxin genes was determined. We analyzed antibiotic susceptibility profiles by VITEK 2 systems and verified methicillin-resistant S. aureus (MRSA) by mecA/C PCR. Among 325 patients, 15.4% carried methicillin-susceptible S. aureus (MSSA) at admission, while 3.7% carried MRSA. The incidence densities of nosocomial infections due to MSSA and MRSA were 35.4 and 6.2 infections per 10,000 patient-days, respectively. Among all 47 nosocomial infections, skin and soft-tissue (40.4%) and bones or joints’ (25.5%) infections predominated. Six (12.7%) infection-related S. aureus isolates harbored PVL genes including two (4.2%) MRSA: overall, seventeen (36.2%) isolates carried pyrogenic toxin superantigens or other toxin genes. This study illustrates the considerable nosocomial impact of S. aureus in a Nigerian University hospital. Furthermore, they indicate a need for effective approaches to curtail nosocomial acquisition of multidrug-resistant S. aureus.
Author: | Adeniran Adeyanju, Frieder Schaumburg, Adedeji Onayade, Akinyele Akinyoola, Taofeeq Adeyemi, Osaretin Ugbo, Robin Köck, Yemisi Amusa, Oladejo Lawal, Temilade Adeyanju, Nkem Torimiro, David Akinpelu, Deboye Kolawole, Christian Kohler, Karsten Becker |
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URN: | urn:nbn:de:gbv:9-opus-75954 |
DOI: | https://doi.org/10.3390/antibiotics11101372 |
ISSN: | 2079-6382 |
Parent Title (English): | Antibiotics |
Publisher: | MDPI |
Place of publication: | Basel |
Editor: | Hiroshi Hamamoto |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2022/10/07 |
Release Date: | 2022/11/14 |
Tag: | MRSA; Panton-Valentine leukocidin; epidermal differentiation inhibitors; exfoliative toxins; nosocomial infection; pyrogenic toxin superantigens; skin and soft-tissue infections; surgical patients |
GND Keyword: | - |
Volume: | 11 |
Issue: | 10 |
Article Number: | 1372 |
Page Number: | 18 |
Faculties: | Universitätsmedizin / Friedrich-Loeffler-Institut für Medizinische Mikrobiologie |
Licence (German): | Creative Commons - Namensnennung |