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Comparison of Transepidermal Water Loss and Laser Scanning Microscopy Measurements to Assess Their Value in the Characterization of Cutaneous Barrier Defects

  • The exact qualitative and quantitative analysis of wound healing processes is a decisive prerequisite for optimizing wound care and for therapy control. Transepidermal water loss (TEWL) measurements are considered to be the standard procedure for assessing the progress of epidermal wound healing. The damage to the stratum corneum correlates with an increased loss of water through the skin barrier. This method is highly susceptible to failure by environmental factors, in particular by temperature and moisture. This study was aimed at comparing TEWL measurements and in vivo laser scanning microscopy (LSM) for the characterization of the epidermal wound healing process. LSM is a high-resolution in vivo method permitting to analyze the kinetics and dynamics of wound healing at a cellular level. While the TEWL values for the individual volunteers showed a wide scattering, LSM permitted the wound healing process to be clearly characterized at the cellular level. However, a comparison between the two methods was very difficult, because the results provided by LSM were images and not numerical. Therefore, a scoring system was set up which evaluates the stages of wound healing. Thus, the healing process could be numerically described. This method is independent of any environmental factors. Providing morphologically qualitative and numerically quantitative analyses of the wound healing process and being far less vulnerable to failure, LSM is advantageous over TEWL.

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Metadaten
Author: V. Czaika, A. Alborova, H. Richter, W. Sterry, T. Vergou, C. Antoniou, J. Lademann, S. Koch
URN:urn:nbn:de:gbv:9-opus-30830
DOI:https://doi.org/10.1159/000330486
ISSN:1660-5527
ISSN:1660-5535
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=21968814
Parent Title (English):Skin Pharmacology and Physiology
Publisher:S. Karger AG
Place of publication:Basel, Switzerland
Document Type:Article
Language:English
Date of first Publication:2011/09/30
Release Date:2020/09/29
Tag:In vivo laser scanning microscopy, Suction blister technique, Transepidermal water loss, Wound healing
GND Keyword:-
Volume:25
Issue:1
First Page:39
Last Page:46
Faculties:Universit├Ątsmedizin / Institut f├╝r Hygiene und Umweltmedizin
Licence (German):License LogoUrheberrechtlich gesch├╝tzt