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Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-30969

Depression Does Not Affect the Treatment Outcome of CBT for Panic and Agoraphobia: Results from a Multicenter Randomized Trial

  • Background: Controversy surrounds the questions whether co-occurring depression has negative effects on cognitivebehavioral therapy (CBT) outcomes in patients with panic disorder (PD) and agoraphobia (AG) and whether treatment for PD and AG (PD/AG) also reduces depressive symptomatology. Methods: Post-hoc analyses of randomized clinical trial data of 369 outpatients with primary PD/AG (DSM-IV-TR criteria) treated with a 12-session manualized CBT (n = 301) and a waitlist control group (n = 68). Patients with comorbid depression (DSM-IV-TR major depression, dysthymia, or both: 43.2% CBT, 42.7% controls) were compared to patients without depression regarding anxiety and depression outcomes (Clinical Global Impression Scale [CGI], Hamilton Anxiety Rating Scale [HAM-A], number of panic attacks, Mobility Inventory [MI], Panic and Agoraphobia Scale, Beck Depression Inventory) at post-treatment and follow-up (categorical). Further, the role of severity of depressive symptoms on anxiety/depression outcome measures was examined (dimensional). Results: Comorbid depression did not have a significant overall effect on anxiety outcomes at post-treatment and follow-up, except for slightly diminished post-treatment effect sizes for clinician-rated CGI (p = 0.03) and HAM-A (p = 0.008) when adjusting for baseline anxiety severity. In the dimensional model, higher baseline depression scores were associated with lower effect sizes at post-treatment (except for MI), but not at follow-up (except for HAM-A). Depressive symptoms improved irrespective of the presence of depression. Conclusions: Exposure-based CBT for primary PD/AG effectively reduces anxiety and depressive symptoms, irrespective of comorbid depression or depressive symptomatology.

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Author: Angela Emmrich, Katja Beesdo-Baum, Andrew T. Gloster, Susanne Knappe, Michael Höfler, Volker Arolt, Jürgen Deckert, Alexander L. Gerlach, Alfons Hamm, Tilo Kircher, Thomas Lang, Jan Richter, Andreas Ströhle, Peter Zwanzger, Hans-Ulrich Wittchen
URN:urn:nbn:de:gbv:9-opus-30969
URL:http://www.karger.com/pps
DOI:https://doi.org/10.1159/000335246
ISSN:0033-3190
ISSN:1423-0348
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/22399019
Parent Title (English):Psychotherapy and Psychosomatics
Publisher:S. Karger AG
Place of publication:Basel, Switzerland
Document Type:Article
Language:English
Date of first Publication:2012/03/03
Release Date:2020/09/29
Tag:Agoraphobia; Cognitive-behavioral therapy; Comorbidity; Depression; Exposure; Panic disorder; Randomized controlled trial
GND Keyword:-
Volume:81
Issue:3
First Page:161
Last Page:172
Faculties:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Psychologie
Licence (German):License LogoUrheberrechtlich geschützt