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Bile Acids: Key Players in Inflammatory Bowel Diseases?
- Inflammatory bowel diseases (IBDs) have emerged as a public health problem worldwide with a limited number of efficient therapeutic options despite advances in medical therapy. Although changes in the gut microbiota composition are recognized as key drivers of dysregulated intestinal immunity, alterations in bile acids (BAs) have been shown to influence gut homeostasis and contribute to the pathogenesis of the disease. In this review, we explore the interactions involving BAs and gut microbiota in IBDs, and discuss how the gut microbiota–BA–host axis may influence digestive inflammation.
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| Author: | Aicha Kriaa, Vincent Mariaule, Amin Jablaoui, Soufien Rhimi, Hela Mkaouar, Juan Hernandez, Brice Korkmaz, Adam Lesner, Emmanuelle Maguin, Ali Aghdassi, Moez Rhimi |
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| URN: | urn:nbn:de:gbv:9-opus-61221 |
| DOI: | https://doi.org/10.3390/cells11050901 |
| ISSN: | 2073-4409 |
| Parent Title (English): | Cells |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Editor: | Laura Grasa |
| Document Type: | Article |
| Language: | English |
| Date of first Publication: | 2022/03/05 |
| Release Date: | 2022/11/15 |
| Tag: | bile acids; gut microbiota; holobiont; inflammatory bowel diseases; microbiome |
| GND Keyword: | - |
| Volume: | 11 |
| Issue: | 5 |
| Faculties: | Universitätsmedizin / Kliniken und Polikliniken für Innere Medizin |
| Licence (German): |  Creative Commons - Namensnennung |