Atrial Cardiomyopathy: pathophysiology and clinical consequences
- Around the world there are 33.5 million patients suffering from atrial fibrillation (AF) with an annual increase of 5 million cases. Most AF patients have an established form of an atrial cardiomyopathy. The concept of atrial cardiomyopathy was introduced in 2016. Thus, therapy of underlying diseases and atrial tissue changes appear as a cornerstone of AF therapy. Furthermore, therapy or prevention of atrial endocardial changes has the potential to reduce atrial thrombogenesis and thereby cerebral stroke. The present manuscript will summarize the underlying pathophysiology and remodeling processes observed in the development of an atrial cardiomyopathy, thrombogenesis, and atrial fibrillation. In particular, the impact of oxidative stress, inflammation, diabetes, and obesity will be addressed.
| Author: | Andreas Goette, Uwe Lendeckel |
|---|---|
| DOI: | https://doi.org/https://doi.org/10.3390/cells10102605 |
| Parent Title (English): | Cells |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2021/09/30 |
| Release Date: | 2022/06/02 |
| Tag: | atrial fibrillation; cardiomyopathy; inflammation; molecular biology; oxidative stress |
| Volume: | 10 |
| Issue: | 10 |
| Article Number: | 2605 |
| Page Number: | 21 |
| Faculties: | Universitätsmedizin / Kliniken und Polikliniken für Innere Medizin |
| Collections: | Artikel aus DFG-gefördertem Publikationsfonds |
| Licence (German): |  Creative Commons - Namensnennung |