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Verhalten des Renin-Angiotensin-Aldosteron-Systems in Abhängigkeit vom hämödynamischen Reaktionstyp bei Salzbelastung
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- An inadequate reaction of the RAAS is taken as a possible cause for salt induced hypertension. Recent investigations suggested that sodium-sensitive hypertensive subjects showed a reduced stimulation of RAAS. Methods: In this randomised doubble-blind study we examined the reaction of RAAS under defined sodium diets (restriction; 60 mmol/d and depletion: 260 mmol/d) of 32 sodium-sensitive or resistant normotonic healthy male subjects. Plasma renin activity (PRA) and aldosterone concentration (AC) were detected by radioimmunoassay at the end of every diet. Results: 11 controls showed sodium- sensitive blood pressure reaction, while 21 controls were considered to be sodium-resistant. There was no significant difference found in PRA and AC, as well as there was no difference of stimulation of RAAS detectable in comparison of both groups. Conclusion: Sodium-sensitive normotonic controls showed a regular function of RAAS.
Author: | Sylvia Tschötschel |
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URN: | urn:nbn:de:gbv:9-200121-9 |
Title Additional (English): | The effect of high-sodium intake on the Renin-Angiotensin-Aldosteron-System (RAAS) in dependence of haemodynamic reaction |
Advisor: | Prof. Dr. Günter Kraatz |
Document Type: | Doctoral Thesis |
Language: | German |
Date of Publication (online): | 2006/07/17 |
Granting Institution: | Ernst-Moritz-Arndt-Universität, Medizinische Fakultät (bis 2010) |
Date of final exam: | 2001/12/10 |
Release Date: | 2006/07/17 |
Tag: | Hypertension; RAAS; Renin-Angiotensin-Aldosterone System; Salt sensitivity |
GND Keyword: | Renin-Angiotensin-System, Salzbelastung, Verhalten |
Faculties: | Universitätsmedizin / Kliniken und Polikliniken für Innere Medizin |
DDC class: | 600 Technik, Medizin, angewandte Wissenschaften / 610 Medizin und Gesundheit |