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Verhalten des Renin-Angiotensin-Aldosteron-Systems in Abhängigkeit vom hämödynamischen Reaktionstyp bei Salzbelastung

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  • An inadequate reaction of the RAAS is taken as a possible cause for salt induced hypertension. Recent investigations suggested that sodium-sensitive hypertensive subjects showed a reduced stimulation of RAAS. Methods: In this randomised doubble-blind study we examined the reaction of RAAS under defined sodium diets (restriction; 60 mmol/d and depletion: 260 mmol/d) of 32 sodium-sensitive or resistant normotonic healthy male subjects. Plasma renin activity (PRA) and aldosterone concentration (AC) were detected by radioimmunoassay at the end of every diet. Results: 11 controls showed sodium- sensitive blood pressure reaction, while 21 controls were considered to be sodium-resistant. There was no significant difference found in PRA and AC, as well as there was no difference of stimulation of RAAS detectable in comparison of both groups. Conclusion: Sodium-sensitive normotonic controls showed a regular function of RAAS.

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Metadaten
Author: Sylvia Tschötschel
URN:urn:nbn:de:gbv:9-200121-9
Title Additional (English):The effect of high-sodium intake on the Renin-Angiotensin-Aldosteron-System (RAAS) in dependence of haemodynamic reaction
Advisor:Prof. Dr. Günter Kraatz
Document Type:Doctoral Thesis
Language:German
Date of Publication (online):2006/07/17
Granting Institution:Ernst-Moritz-Arndt-Universität, Medizinische Fakultät (bis 2010)
Date of final exam:2001/12/10
Release Date:2006/07/17
Tag:Hypertension, RAAS, Renin-Angiotensin-Aldosterone System, Salt sensitivity
GND Keyword:Renin-Angiotensin-System, Salzbelastung, Verhalten
Faculties:Universitätsmedizin / Klinik und Poliklinik für Innere Medizin
DDC class:600 Technik, Medizin, angewandte Wissenschaften / 610 Medizin und Gesundheit