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Oxidative Stress and Microcirculatory Flow Abnormalities in the Ventricles during Atrial Fibrillation

  • Patients with atrial fibrillation (AF) often present with typical angina pectoris and mildly elevated levels of cardiac troponin (non-ST-segment elevation myocardial infarction) during an acute episode of AF. However, in a large proportion of these patients, significant coronary artery disease is excluded by coronary angiography, which suggests that AF itself influences myocardial blood flow. The present review summarizes the effect of AF on the occurrence of ventricular oxidative stress, redox-sensitive signaling pathways and gene expression, and microcirculatory flow abnormalities in the left ventricle.

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Metadaten
Author: Andreas Goette, Alicja Bukowska, Christopher H. Lillig, Uwe Lendeckel
URN:urn:nbn:de:gbv:9-opus-32819
DOI:https://doi.org/10.3389/fphys.2012.00236
ISSN:1664-042X
Parent Title (English):Frontiers in Physiology
Publisher:Frontiers Research Foundation
Document Type:Article
Language:English
Date of first Publication:2012/07/05
Release Date:2020/10/08
Tag:angiotensin; atrial fibrillation; microvascular flow; oxidative stress
GND Keyword:-
Volume:3
Faculties:Universitätsmedizin / Institut für Med. Biochemie u. Molekularbiologie
Licence (German):License LogoUrheberrechtlich geschützt