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Untersuchungen zur Expression von P-Glycoprotein an Hirngewebsproben bei Patienten mit pharmacoresistenter Epilepsie

  • keine Angaben
  • Slices of human cortical tissue from epilepsy surgery were investigated. This were patients with medically intractable epilepsy inspite of sufficient serum antiepileptic drug concentrations. The human P-Glycoprotein (P-Glycoprotein, MDR 1) is an ATP-driven transporter for hydrophobic drugs and causes multidrug resistance in cancer. P-Glycoprotein is localised in the endothelial cells of vessels of the brain and it contributions to the blood brain barrier (BBB), since some AEDs (antiepileptic drugs) are substrates of P-Glycoprotein they can not be effective due to the efflux transport. It is suggested that a medically intractable epilepsy on its own does not ineritably lead to an increased P-Glycoprotein expression , but it does in combination with focal cortical dysplasia.

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Metadaten
Author: Klaudija Kozulovic
URN:urn:nbn:de:gbv:9-000071-9
Title Additional (German):keine Angaben
Title Additional (English):Investigations of P-Glycoprotein expression in brain specimens of patients with medically intractable epilepsy
Advisor:Dr. S. Vogelgesang, Prof. Dr. Rolf Warzok
Document Type:Doctoral Thesis
Language:German
Date of Publication (online):2006/07/11
Granting Institution:Ernst-Moritz-Arndt-Universität, Medizinische Fakultät (bis 2010)
Date of final exam:2005/07/06
Release Date:2006/07/11
GND Keyword:ATP-Stoffwechsel, Epilepsie
Faculties:Universit√§tsmedizin / Institut f√ľr Pathologie
DDC class:600 Technik, Medizin, angewandte Wissenschaften / 610 Medizin und Gesundheit