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Kinetics of Physiological Skin Flora in a Suction Blister Wound Model on Healthy Subjects after Treatment with Water-Filtered Infrared-A Radiation

  • The effect of water-filtered infrared-A radiation (wIRA) on normal skin flora was investigated by generating experimental wounds on the forearms of volunteers utilizing the suction blister technique. Over 7 days, recolonization was monitored parallel to wound healing. Four groups of treatment were compared: no therapy (A), dexpanthenol cream once daily (B), 20 min wIRA irradiation at 30 cm distance (C), and wIRA irradiation for 30 min once daily together with dexpanthenol cream once daily (D). All treatments strongly inhibited the recolonization of the wounds. Whereas dexpanthenol completely suppressed recolonization over the test period, recolonization after wIRA without (C) and in combination with dexpanthenol (D) was suppressed, but started on day 5 with considerably higher amounts after the combination treatment (D). Whereas the consequence without treatment (A) was an increasing amount of physiological skin flora including coagulase-negative staphylococci, all treatments (B–D) led to a reduction in physiological skin flora, including coagulase-negative staphylococci. In healthy volunteers, wIRA alone and in combination with dexpanthenol strongly inhibited bacterial recolonization with physiological skin flora after artificial wound setting using a suction-blister wound model. This could support the beneficial effects of wIRA in the promotion of wound healing.

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Metadaten
Author: G. Daeschlein, J. Alborova, A. Patzelt, A. Kramer, J. Lademann
URN:urn:nbn:de:gbv:9-opus-30825
DOI:https://doi.org/10.1159/000332753
ISSN:1660-5527
ISSN:1660-5535
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/22123525
Parent Title (English):Skin Pharmacology and Physiology
Publisher:S. Karger AG
Place of publication:Basel, Switzerland
Document Type:Article
Language:English
Date of first Publication:2011/11/25
Release Date:2020/09/29
Tag:Energy supply; Oxygen supply; Suction blister; Water-filtered infrared-A radiation; Wound colonization
GND Keyword:-
Volume:25
Issue:2
First Page:73
Last Page:77
Faculties:Universitätsmedizin / Institut für Hygiene und Umweltmedizin
Licence (German):License LogoUrheberrechtlich geschützt