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A Novel C3/C4-Fused Indole Scaffold through Acid-Catalyzed Cascade Reaction
- 3,4-bridged indoles are underrepresented among the vast number of indoles described in the literature. Attempts to access 3,4-macrocyclized indoles led to the unexpected formation of a novel tetracyclic indole through intramolecular acid-catalyzed ring contraction. The herein-established one-step synthetic route provides an excellent medicinal chemistry platform for the construction of screening libraries covering a unique chemical space of indoles.
| Author: | Felix PotlitzORCiD, Gottfried J. PalmORCiD, Anja Bodtke, Michael LammersORCiD, Dennis SchadeORCiD, Andreas LinkORCiD |
|---|---|
| URN: | urn:nbn:de:gbv:9-opus-113292 |
| DOI: | https://doi.org/10.3390/molecules29133064 |
| ISSN: | 1420-3049 |
| Parent Title (English): | Molecules |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of first Publication: | 2024/06/27 |
| Release Date: | 2024/11/22 |
| Tag: | cascade reaction; chemical diversity; indoles |
| Volume: | 29 |
| Issue: | 13 |
| Article Number: | 3064 |
| Page Number: | 7 |
| Faculties: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Pharmazie |
| Collections: | weitere DFG-förderfähige Artikel |
| Licence (German): |  Creative Commons - Namensnennung 4.0 International |