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Understanding the interaction between climate variability and ice sheet behavior is critical due to scenarios of future climate warming and the consequent contribution of Greenland ice sheet melting to sea-level rise and its potential to influence thermohaline circulation. This thesis investigates the role of ocean forcing by the West Greenland Current (WGC) on the dynamics of West Greenland ice sheet behavior, with focus on Jakobshavn Isbræ, in the Disko Bugt area of central West Greenland. High-resolution sediment cores, obtained during a cruise of the RV ‘Maria S. Merian’ in 2007, provide a long-term Holocene perspective on climate variability off West Greenland. These records cover the last 8000 years with increasing resolution through to periods of historical and instrumental data series. Paleoenvironmental reconstructions, based on the calcareous and agglutinated benthic foraminiferal assemblage, reveal significant variations in the water mass properties (e.g. temperature and salinity) of the WGC. From 8 to 6 cal. ka BP, a relatively warm WGC enhances meltwater production (ice retreat) in Disko Bugt. Holocene ‘thermal optimum-like’ conditions prevailed from 5.5 to 3.5 cal. ka BP, associated with minimum ice sheet extent in eastern Disko Bugt. Long-term cooling of oceanographic conditions is recognized from c. 3.5 cal. ka BP towards the present day. Superimposed on this millennial scale cooling trend, centennial scale variability within the WGC is reconstructed: i) the 2.7 cal. ka BP ‘cooling event’; ii) the Roman Warm Period; iii) the Medieval Climate Anomaly; and iv) the Little Ice Age. Over the past 100 years, oceanographic conditions remain relatively cool and multidecadal variability in the WGC’s ocean temperatures show close correlation with the ice marg in position of Jakobshavn Isbræ and phases of the Atlantic Multi-decadal Oscillation (AMO). Cold (warm) phases correlate with stabilization/re-advance (retreat) of Jakobshavn Isbræ and a negative (high) index of the AMO. It has been demonstrated that variations in ocean temperature are an important factor that influence ice sheet behavior on a range of times scales, underlining the close coupling of ice-ocean interactions during the Holocene. Warmer ocean temperatures influence the stability of marine terminating ice sheets and glaciers, causing basal melting and glacier acceleration, whereas ocean cooling supports stabilization and advance of ice margin.