Refine
Document Type
- Article (12)
- Doctoral Thesis (1)
Language
- English (13)
Has Fulltext
- yes (13)
Is part of the Bibliography
- no (13)
Keywords
- - (8)
- Staphylococcus aureus (4)
- <i>Staphylococcus aureus</i> (3)
- host adaptation (3)
- JSNZ (2)
- antibody (2)
- colonization (2)
- <i>Streptococcus mutans</i> (1)
- <i>Streptococcus oralis</i> (1)
- ATA (1)
- Antibacterial efficacy (1)
- Antikörper (1)
- Autoimmunity (1)
- Brainstem (1)
- CC88 (1)
- CD4 (1)
- Carrier (1)
- Cold atmospheric pressure plasma (1)
- Encephalitis (1)
- Epitopes (1)
- GWA (1)
- Genotypisierung (1)
- HLA (1)
- IgE (1)
- Immunreaktion (1)
- IsdB (1)
- Long-COVID (1)
- MHC (1)
- MSCRAMM (1)
- Methicillin-resistant (1)
- NLRP3 inflammasome (1)
- Polymerase-Kettenreaktion (1)
- SARS-CoV-2 (1)
- Staphyloccus aureus (1)
- Superantigen (1)
- T cell superallergen (1)
- T cells (1)
- T-Lymphozyt (1)
- TLR4 (1)
- TSST-1 (1)
- Tolerability (1)
- Virulence (1)
- adhesion inhibitor (1)
- allergy (1)
- alpha-toxin (1)
- anti- (1)
- antibody repertoire (1)
- aurintricarboxylic acid (1)
- clonal complex (1)
- coagulation (1)
- cytokines (1)
- dirty mouse (1)
- egc superantigens (1)
- egc-Superantigene (1)
- epidemiology (1)
- genotype (1)
- genotyping (1)
- habitat (1)
- host-pathogen-interaction (1)
- immune evasion cluster (1)
- immunoproteomics (1)
- innate immunity (1)
- innate lymphoid cells (1)
- laboratory (1)
- laboratory mice (1)
- livestock (1)
- mouse (1)
- mouse models (1)
- multi-species biofilm (1)
- mupirocin (1)
- neutralisierende Antikörper (1)
- neutralizing antibodies (1)
- nose (1)
- proteomic analysis (1)
- rat (1)
- sensitization (1)
- superantigen (1)
- superantigens (1)
- toxic shock syndrome (1)
- vaccine (1)
- wildling (1)
- γδ T cells (1)
Institute
- Institut für Immunologie u. Transfusionsmedizin - Abteilung Immunologie (10)
- Institut für Botanik und Landschaftsökologie & Botanischer Garten (1)
- Institut für Community Medicine (1)
- Interfakultäres Institut für Genetik und Funktionelle Genomforschung (UMG) (1)
- Klinik und Poliklinik für Neurologie (1)
Publisher
- MDPI (5)
- Frontiers Media S.A. (4)
- American Society for Microbiology (ASM) (1)
- Elsevier (1)
- S. Karger AG (1)
Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus. A well-known risk factor is the lack of neutralizing antibodies. To identify determinants of the anti-TSST-1 antibody response, we examined 976 participants of the German population-based epidemiological Study of Health in Pomerania (SHIP-TREND-0). We measured anti-TSST-1 antibody levels, analyzed the colonization with TSST-1-encoding S. aureus strains, and performed a genome-wide association analysis of genetic risk factors. TSST-1-specific serum IgG levels varied over a range of 4.2 logs and were elevated by a factor of 12.3 upon nasal colonization with TSST-1-encoding S. aureus. Moreover, the anti-TSST-1 antibody levels were strongly associated with HLA class II gene loci. HLA-DRB1*03:01 and HLA-DQB1*02:01 were positively, and HLA-DRB1*01:01 as well as HLA-DQB1*05:01 negatively associated with the anti-TSST-1 antibody levels. Thus, both toxin exposure and HLA alleles affect the human antibody response to TSST-1.