Refine
Document Type
- Article (14)
Language
- English (14)
Has Fulltext
- yes (14)
Is part of the Bibliography
- no (14)
Keywords
- - (7)
- plasma medicine (2)
- Absorption (1)
- Acetic acid (1)
- Antibacterial efficacy (1)
- Antiseptic mouth rinse (1)
- Antiseptics (1)
- Biocidal product regulation (1)
- CAP (1)
- Cold atmospheric pressure plasma (1)
- Cytokine secretion (1)
- Drug (1)
- Dyes (1)
- Ethanol based hand rub (1)
- Granudacyn® (1)
- Hand antisepsis (1)
- Hydrogen peroxide (1)
- Hypochlorite (1)
- Hypochlorous acid (1)
- Implant surface (1)
- Inactivation (1)
- Iodine status (1)
- Iodophors (1)
- Medical device (1)
- Memorandum (1)
- Mercury compounds (1)
- Methicillin-resistant (1)
- Molecular dynamics simulation (1)
- Mucositis (1)
- Negative pressure wound therapy with the instillation of antiseptics (1)
- Non-enveloped viruses (1)
- Octenidine (1)
- Octenidine dihydrochlorid (1)
- Octenidol® md (1)
- PHMB (1)
- PHMB adsorption (1)
- Patient safety (1)
- Physical body warm atmospheric plasma (1)
- Polihexanide (1)
- Poly (hexamethylene biguanide) hydrochloride (PHMB) (1)
- Poly(hexamethylene)biguanide (1)
- Prediction (1)
- RNS (1)
- ROS (1)
- Risk–benefit-assessment (1)
- Rose Bengal staining (1)
- SR101 (1)
- SaOs‐2 cell differentiation (1)
- Silver ions (1)
- Silver sulfadiazine (1)
- Sodium hypochlorite (1)
- TEER (1)
- THP-1 macrophages (1)
- Taurolidine (1)
- Ti6Al4V (1)
- Ti6Al4V alloy (1)
- TiO2 (1)
- Tolerability (1)
- UVA-LED (1)
- UVA-responsive (1)
- Urinary iodine excretion (1)
- Virulence (1)
- WHO (1)
- Worker safety (1)
- Wound antisepsis (1)
- Wounds-at-Risk Score (1)
- antimicrobial coating (1)
- antiseptics (1)
- apoptosis (1)
- cancer (1)
- carbon contamination (1)
- chronic wounds (1)
- cold physical plasma (1)
- confocal laser scanning microscopy (1)
- contact killing surface (1)
- cost analysis (1)
- cytotoxicity (1)
- donor human milk (1)
- dynamic light scattering (1)
- hair follicles (1)
- hydroxyethyl starch (1)
- implant coating (1)
- infected wounds (1)
- maternal breast milk (1)
- micelle (1)
- milk bank (1)
- mouth rinse (1)
- mucosa model (1)
- mucositis (1)
- nanocapsules (1)
- osseointegration (1)
- osteosarcoma (1)
- plasma discharge (1)
- plasma oncology (1)
- preterm infant (1)
- reactive oxygen species (1)
- surface modification (1)
- titanium alloys (1)
- water contact angle (1)
- wetting (1)
Institute
Publisher
- MDPI (5)
- BioMed Central (BMC) (3)
- S. Karger AG (3)
- Wiley (2)
- IOP Publishing (1)
Objectives
Oral mucositis caused by intensive cancer chemotherapy or radiotherapy frequently results in pronounced damage of the oral mucosa leading to painful oral hygiene. To support oral care, antimicrobial effective mouth rinses may be used. Thus, the efficacy of a hypochlorite-based mouth rinse (Granudacyn®), assumed to be highly biocompatible because of the compounds being part of the natural pathogen defense, as possible antiseptic agent in case of oral mucositis was compared to that of an octenidine based antiseptic mouth rinse (Octenidol® md).
Materials and methods
The study was conducted as monocentric, controlled, randomized, blind cross over comparative study on 20 volunteers. As a proof of principle, we performed the study on orally healthy subjects and not cancer patients. The efficacy was determined as reduction of colony forming units (cfu) on buccal mucosa as well as in saliva. After mouth rinsing for 30 s, samples were taken after 1 min, 15 min, 30 and 60 min. The lg-reduction was calculated as difference between lg-values of cfu pre- and post-treatment.
Results
Both antiseptic mouth rinses induced a significant reduction of cfu on buccal mucosa and in saliva 1 min after mouth rinsing. The effect persisted up to 60 min. The octenidine based rinse was significantly superior to the hypochlorite-based rinse up to the last sample 60 min after rinsing. However, the known cytotoxicity of octenidine argues against its application.
Conclusion
Within the limits of this study, due to its antiseptic efficacy, the hypochlorite-based rinse Granudacyn® can be regarded appropriate to support the oral hygiene in patients with a sensitive oral mucosa during an aggressive cancer chemotherapy and radiation treatment in case of oral mucositis.