Refine
Year of publication
- 2019 (222) (remove)
Document Type
- Article (167)
- Doctoral Thesis (55)
Language
- English (222) (remove)
Has Fulltext
- yes (222)
Is part of the Bibliography
- no (222)
Keywords
- - (114)
- proteomics (7)
- metabolomics (4)
- periodontitis (4)
- <i>Staphylococcus aureus</i> (3)
- Caries epidemiology (3)
- Caries experience (3)
- Proteomics (3)
- Streptococcus pneumoniae (3)
- <i>Bacillus subtilis</i> (2)
- <i>Streptococcus pyogenes</i> (2)
- Allogeneic stem cell transplantation (2)
- Araneae (2)
- BK virus (2)
- Career (2)
- Caries (2)
- Caries index (2)
- Childhood trauma (2)
- Children (2)
- Chorea (2)
- Colonization (2)
- Consensus (2)
- Dental caries (2)
- Dental caries management (2)
- Dental caries terms (2)
- Depression (2)
- Feminization (2)
- Fledermäuse (2)
- Functional connectivity (2)
- German (2)
- Haemorrhagic cystitis (2)
- Magnetic resonance imaging, 7 T (2)
- Malabsorption (2)
- Maldigestion (2)
- Modellierung (2)
- Multi-reflection time-of-flight mass spectrometry (2)
- Pancreatic resection (2)
- Patient management (2)
- Posttraumatic stress disorder (2)
- Prefrontal cortex (2)
- Premanifest period (2)
- Satisfaction (2)
- Self-stigma (2)
- Significant Caries Index (2)
- Spanish (2)
- Stereotypes (2)
- Substance use disorders (2)
- Surgical discipline (2)
- Work-life balance (2)
- aerogel (2)
- age (2)
- antares (2)
- antimicrobial photodynamic therapy (2)
- apoptosis (2)
- autocorrelation (2)
- biomarker (2)
- biomarkers (2)
- bolaform amphiphilic lipids (2)
- bolalipids (2)
- borrowing (2)
- calques (2)
- cardiorespiratory fitness (2)
- central blood pressure (2)
- chorioallantoic membrane model (2)
- contact linguistics (2)
- depression (2)
- drug delivery system (2)
- emotion regulation (2)
- gender (2)
- group A streptococcus (2)
- hydrogel (2)
- immune responses (2)
- immunomodulatory proteases (2)
- invasive (2)
- ion mass spectrometry (2)
- lexis (2)
- magnetron sputtering (2)
- mass separation (2)
- measurement error (2)
- metabolism (2)
- metagenomics (2)
- metaproteomics (2)
- microbiome (2)
- mitochondria (2)
- necrotizing soft tissue infections (2)
- order pattern (2)
- oxidative stress (2)
- permutation entropy (2)
- pore-forming toxins (2)
- proteasome (2)
- pulse wave analysis (2)
- self-assembly (2)
- sepsis (2)
- signal processing (2)
- single nucleotide polymorphism (2)
- skin infections (2)
- stress response (2)
- superantigens (2)
- time series (2)
- validation (2)
- 1,4-naphthoquinones (1)
- 3D (1)
- 90-day mortality (1)
- <i>Argiope bruennichi</i> (1)
- <i>S. aureus</i> (1)
- <i>lpxM</i> (<i>msbB</i>) (1)
- AFLP (1)
- Absorption (1)
- Adhesion (1)
- Adolescents, 12-year-olds (1)
- Adoleszenz (1)
- Algorithmen (1)
- Anpassung (1)
- Anti-adhesive (1)
- Antimicrobial (1)
- Antrieb (1)
- ArcT peptidase (1)
- Argininphosphorylierung (1)
- Artificial nerual networks (1)
- Arxula adeninivoras (1)
- Atmosphärendruckplasma (1)
- Ausbreitung (1)
- BAYES (1)
- BDNF (1)
- Behavioural ecology (1)
- Berlin (1)
- Bicarbonate (1)
- Bioakustik (1)
- Biocatalysis (1)
- Biochemie (1)
- Biocomputational metho (1)
- Bioethik (1)
- Biomolecules (1)
- Biopharmazie (1)
- Biophysikalische Chemie (1)
- Biorelevant (1)
- Biotechnology (1)
- Bone fracture (1)
- Brain Stimulation (1)
- Brain stimulation (1)
- C-reactive protein (1)
- CAL-A (1)
- CANDLE/PRAAS (1)
- CAP (1)
- CD44 (1)
- CKD (1)
- CNV analyses (1)
- CRISPR/Cas9 (1)
- CRM brand Personality (1)
- CRM purchase intention (1)
- CT (1)
- CTLA-4 (1)
- Caledonian Deformation Front (1)
- Calvatia gigantea (1)
- Carcinus maenas (1)
- Cardiolipin (1)
- Caries prevalence (1)
- Caries prevalence (1)
- Caries trends (1)
- Cause Related Marketing (CRM) (1)
- Chemical Stability (1)
- Chemische Stabilität (1)
- China (1)
- Chlorella vulgaris (1)
- Climate change (1)
- Clinimetrics (1)
- Cloning (1)
- Coagulation (1)
- Cognition (1)
- Collagen (1)
- Consumer culture (1)
- Convergence of Markov chains (1)
- Corrosion-electrochemical behaviour (1)
- Cytotoxic (1)
- D61Y mutation (1)
- DNA-barcoding (1)
- DTI (1)
- Dark Ages Cold Period (DACP) (1)
- Dendrochronologie , Moor , Kiefer <Gattung> (1)
- Deutschland (1)
- Diabetes mellitus (1)
- Diagnostik (1)
- Dirofilaria (1)
- Dispersal (1)
- Dissemination (1)
- Divertor (1)
- Dünndarm (1)
- E. coli (1)
- ER stress (1)
- Early mobilization (1)
- Eberswalde (1)
- Ecophysiology (1)
- Electrochemical Stability (1)
- Elektrochemie (1)
- Elektrochemische Stabilität (1)
- Empfindlichkeit (1)
- Entladung (1)
- Enzym (1)
- Erucic acid (1)
- Ethik (1)
- Exploration (1)
- Extraktion (1)
- FCGR polymorphism (1)
- Fatty acid enrichment (1)
- Fc gamma receptor (1)
- Feldmaus (1)
- Fernerkundung (1)
- Festkörperphysik (1)
- Fetal zone steroids (1)
- Fibronectin (1)
- Flupirtine (1)
- Fomitopsis betulina (1)
- Fällung (1)
- GPR68 (1)
- GastroDuo (1)
- Gedächtniszelle (1)
- Genetic (1)
- Genetik (1)
- Genetische Variabilität (1)
- Germany (1)
- Geschlechterverhältnis (1)
- Gingival index (1)
- Gleichgewicht (1)
- Gompertz (1)
- Gondoic acid (1)
- Gouldian finch (1)
- Graphische Darstellung (1)
- Gromov-Wasserstein distance (1)
- Group B streptococcus (1)
- HEV (1)
- Hausratte (1)
- Head injury (1)
- Heat load (1)
- Heatwave (1)
- Hemolysis (1)
- Henrik Ibsen (1)
- Hepatitis-E-Virus (1)
- Hepatotoxicity (1)
- HiPIMS (1)
- Highest density regions (1)
- Hippocampal network integrity (1)
- Holocene climate change (1)
- Human thrombospondin-1 (1)
- Hyperoxie (1)
- ICU‐acquired weakness (1)
- ISOLTRAP (1)
- ISP (1)
- Immediate and postponed effects (1)
- Immunogenicity (1)
- Immunoproteasome (1)
- Immuntherapie (1)
- In vitro (1)
- In vivo (1)
- Individualization (1)
- Infektionen (1)
- Inflammation (1)
- Influenza A virus (1)
- Institutional Analysis (1)
- Integer Linear Program (1)
- Integrin (1)
- Iron limitation (1)
- Jewish apocalypticism (1)
- KHV (1)
- KIR mismatch (1)
- KIR/HLA mismatch (1)
- Kaltes Plasma (1)
- Kaninchen (1)
- Kernfusion (1)
- Kleine Hufeisennase (1)
- Klima (1)
- Klimawandel (1)
- Klimaänderung (1)
- Koi (1)
- Kondo effect (1)
- Korrosion (1)
- Korrosionselektrochemische Verhalten (1)
- Kv7.2/7.3 (1)
- Körperliche Aktivität , Sitzen , Prävention , Fitness , Metabolisches Syndrom , Reaktivität , Kardiovaskuläre Krankheit , Messung (1)
- Künstliche Intelligenz (1)
- LMP2 (1)
- LMP7 (1)
- Ladder of Jacob (1)
- Ladungstransfer (1)
- Langmuir Monolayers (1)
- Larvalentwicklung (1)
- Lebensgeschichte (1)
- Lipase (1)
- Lipid Modification (1)
- Lipoprotein (1)
- Luftleuchten (1)
- MCMC (1)
- MECL-1 (1)
- MR-ToF MS (1)
- MSFD (1)
- Machine learning (1)
- Magen (1)
- Magnetic Resonance Imaging (1)
- Magnetic edge properties (1)
- Magnetische Kernresonanz (1)
- Markov-Kette (1)
- Mass spectrometry (1)
- Massenspektrometrie (1)
- Mathematical Phylogenetic (1)
- Mathematical bioscience (1)
- Mathematische Phylogenetik (1)
- Medically unknown symptoms (1)
- Medieval Climate Anomaly (MCA) (1)
- Melanom (1)
- Melanoma (1)
- Membrane proteins (1)
- Memory T cell (1)
- Memory function (1)
- Mental Pain Questionnaire (1)
- Mental pain (1)
- Mergers and Acquisitions (1)
- Metagenomik (1)
- Mikroalgen (1)
- Model Membranes (1)
- Model selection (1)
- Molekularbiologie (1)
- Molekulardynamik (1)
- Molybdenum (1)
- Molybdenum Cofactor (1)
- Molybdopterin (1)
- Multinationales Unternehmen (1)
- Mycobiome (1)
- Myotis daubentonii (1)
- Myotis nattereri (1)
- NP-completeness (1)
- Nachtluftleuchten (1)
- Narration of Afroditian (1)
- National survey (1)
- Naturschutz (1)
- Netzwerk (1)
- Neuroblastom (1)
- Neuroimmunologie (1)
- Neuromuscular electrical stimulation (1)
- NorA (1)
- Nord Jasmund Fault (1)
- North Atlantic Oscillation (NAO) (1)
- Nuclear fusion (1)
- Nucleinsäuren (1)
- OAT Reaction (1)
- OGR1 (1)
- ONX-0914 (1)
- Operante Konditionierung (1)
- Optimierung (1)
- Oral hygiene (1)
- Orbital , Verletzung , Trauma , Computertomografie , Bruch , Sehnerv (1)
- Oxidation potential (1)
- Oxidativer Stress (1)
- Oxidoreductases (1)
- PAβN (1)
- Pancreatitis (1)
- Patient-reported outcomes (1)
- Perron-Frobenius theorem (1)
- Petrobaltic (1)
- Pharmacokinetics (1)
- Pharmazeutische Technologie (1)
- Phase Equilibrium (1)
- Phasengleichgewicht (1)
- Phosphate (1)
- Phosphate Substituted Dithiolene (1)
- Phospholipide (1)
- Phospholipids (1)
- Phosphopeptidanreicherung (1)
- Phosphorylierung (1)
- Physikalische Chemie (1)
- Picea glauca (1)
- Pigment (1)
- Plaque index (1)
- Plasma , Plasmaphysik , Laser , Fluoreszenz , Interferometer , Wakefield , CERN , Kielfeld-Beschleuniger , Teilchenbeschleuniger , Laserinduzierte Fluoreszenz (1)
- Plasma physics (1)
- Plasmamedizin (1)
- Plasmaphysik (1)
- Polymere (1)
- Potential – pH Diagram (1)
- Potenzial – pH-Diagramm (1)
- Practical Deliberation (1)
- Practical Identity (1)
- Precipitation inhibitor (1)
- Proteasom (1)
- Protection (1)
- Protein Engineering (1)
- Proteine (1)
- Protocol‐based physiotherapy (1)
- Pädiatrische Onkologie (1)
- Quantifizierung (1)
- RIDD (1)
- RNAlater (1)
- Radial axis shift (1)
- Redox signaling (1)
- Reinforcement learning (1)
- Rekonstruktion (1)
- Roman Climate Anomaly (RCA) (1)
- Rosmersholm (1)
- Rotational transform (1)
- S-thioallylation (1)
- SHP2 (1)
- SNP (1)
- SNPs (1)
- SP3 (1)
- STEM performance (1)
- Sauerstoff (1)
- Sedentary Behavior (1)
- Sepsis (1)
- Sequenzanalyse (1)
- Serotype-independent (1)
- Shiny (1)
- Shockwaves (1)
- Shotgun proteomics (1)
- Shoulders (1)
- Sigmund Freud (1)
- Simulation (1)
- Skeletal joints (1)
- Slavonic apocrypha (1)
- Smartphone app (1)
- Soft tissues (1)
- Soziale Beziehungen (1)
- Spektrenbibliothek (1)
- Spike and Slab (1)
- Staphylococcus aureus (1)
- Staphylococcus aureus, MRSA, USA300, antibiotic resistance, drug evasion. (1)
- Statistik (1)
- Stechmücke (1)
- Stellarator (1)
- Stoß (1)
- Stress (1)
- Struktur (1)
- Supervised learning (1)
- T-Lymphozyt (1)
- TCF11/Nrf1 (1)
- TESZ (1)
- TMS (1)
- TREM-1 (1)
- TTZ (1)
- Targeted proteomics (1)
- Tenericutes (1)
- Thermodynamik (1)
- Thioredoxin (1)
- Tiergesundheit (1)
- Toothbrushing (1)
- Toxoplasma gondii (1)
- Trauma surgery (1)
- Traumatic injury (1)
- Triterpenes (1)
- UPR (1)
- USO-Project (1)
- Ungewissheit (1)
- Unification (1)
- Unsolicited medical opinion (1)
- Utilitarismus (1)
- Vaccine (1)
- Verhaltensforschung (1)
- Vielteilchensystem (1)
- Vielteilchentheorie (1)
- Virologie (1)
- Vitamin B6 deficiency (1)
- Volitional Disunity (1)
- WFD (1)
- Wanderratte (1)
- Warburg effect (1)
- Wasserstoffperoxid (1)
- Weibull (1)
- Wendelstein 7-X (1)
- Whole‐body vibration (1)
- Wiek Fault System (1)
- XRF scanning (1)
- Zellen (1)
- Zoologischer Garten (1)
- accelerometer (1)
- adenine nucleotide translocase 1 (1)
- airglow (1)
- airway epithelial cells (1)
- allicin (1)
- alpha-toxin (1)
- amination (1)
- amine transaminase (1)
- amino alcohols (1)
- angiogenesis (1)
- annually laminated lake sediments (1)
- antibacterial activity (1)
- antibiotics (1)
- antibody (1)
- anticonvulsant (1)
- antiepileptic drug (AED) (1)
- antimicrobial (1)
- antimicrobial activity (1)
- antiseptic stewardship (1)
- apparently healthy (1)
- asymmetric catalysis (1)
- atmospheric pressure (1)
- atomic clusters (1)
- autoinflammation (1)
- autophagy (1)
- avian malaria (1)
- bacillithiol (1)
- bacteria (1)
- bacterial cell disruption (1)
- bats (1)
- bile acids (1)
- bioassay-guided fractionation (1)
- biochemical-clinical traits (1)
- biocide (1)
- biodiversity (1)
- biofilm (1)
- bioinformatics (1)
- biological aging (1)
- biorelevant in vitro model (1)
- biostatistics (1)
- bipolar pulse (1)
- blood cell metabolism (1)
- blood outgrowth endothelial cells (1)
- blood pressure (1)
- bortezomib (1)
- bottleneck (1)
- bovine soft palate (1)
- capture-mark-recapture (1)
- carbon catabolite repression (1)
- cardiolipin composition (1)
- cardiometabolic health (1)
- cardiomyogenic differentiation (1)
- cardioprotection (1)
- cardiorespiratory exercise capacity (1)
- cardiovascular health (1)
- career trajectories (1)
- carp (1)
- case-control study (1)
- castration-resistant prostate cancer (1)
- catechol-1,2-dioxygenase (ACDO1) (1)
- causal beliefs (1)
- cell cycle (1)
- cell physiology (1)
- cell signaling (1)
- cerebral cavernous malformation (1)
- cerebral cavernous malformations (1)
- cerebral hemorrhage (1)
- ch14.18 (1)
- chaperones (1)
- chemosynthesis (1)
- chiral resolution (1)
- chiral stationary phase (1)
- chronic post-stroke aphasia (1)
- cisplatin (1)
- clinical classifications (1)
- clinical diagnosis (1)
- clinical drugs (1)
- clinical practice (1)
- clinical study (1)
- clinical trial (1)
- coated (1)
- codon (1)
- cognitive reappraisal (1)
- cold argon plasma (1)
- competence, oligopeptide (1)
- complete blood count (1)
- complete genome (1)
- complex plasmas (1)
- computer vision (1)
- connectivity (1)
- conservation (1)
- consistent (1)
- corticospinal excitability (1)
- crop production (1)
- cross-cultural psychology (1)
- cross-cultural study (1)
- cross-resistance (1)
- cross-tolerance (1)
- dating (1)
- decontamination (1)
- deforestation and forest degradation (1)
- dementia (1)
- dendrometer (1)
- dental (1)
- developing countries (1)
- diallyl polysulfane (1)
- difficult pro-environmental behaviors (1)
- dinutuximab (1)
- directed acyclic graphs (1)
- dissolution method (1)
- dissolution methods (1)
- diurnal rhythm (1)
- drug release (1)
- drying–rewetting (1)
- dusty plasmas (1)
- eQTL (1)
- ecosystem modeling (1)
- ecosystem service valuation (1)
- ectogenic meromixis (1)
- edentulism (1)
- educational decisions (1)
- efflux pump inhibitor (1)
- eicosanoids (1)
- electron energy loss spectroscopy (1)
- emergence behaviour (1)
- emotion recognition (1)
- endosymbiont (1)
- environmental activism (1)
- enzyme catalysis (1)
- epilepsy (1)
- estrogen (1)
- eutrophication (1)
- evidence-based practice (1)
- exercise (1)
- external evidence (1)
- finger-tapping task (1)
- fingerprinting (1)
- flagella (1)
- flash freezing (1)
- food geographies (1)
- foot-and-mouth disease virus (FMDV) (1)
- forcing (1)
- forest monitoring (1)
- gallic acid decarboxylase (AGDC1) (1)
- gender differences (1)
- gender inequality (1)
- gene expression (1)
- gene library (1)
- genetically encoded sensors (1)
- globalization (1)
- go/no-go task (1)
- haplotypes (1)
- head and neck squamous cell carcinoma (1)
- hearing impairment (1)
- heart failure with preserved ejection fraction (1)
- heart rate (1)
- heart rate variability (1)
- heat shock protein 27 (1)
- helicon, fluorescence, accelerator (1)
- hemoglobin A1c (1)
- hibernation (1)
- high-throughput sequencing (1)
- holobiont (1)
- host preferences (1)
- host-microbe interactions (1)
- human (1)
- human kidneys (1)
- hydrogen peroxide (1)
- hydrothermal vents (1)
- hyperspectral image processing (1)
- imaging (1)
- immobilized (1)
- immune response,European bats,Lyssaviruses (1)
- immunohistochemistry (1)
- immunology (1)
- immunotherapy (1)
- in situ (1)
- individualized medicine (1)
- inductively-limited discharge (1)
- infection (1)
- infectious diseases (1)
- inflammation (1)
- inhibition (1)
- innate immune system (1)
- insulin-producing cells (1)
- intensive speech-language therapy (1)
- interferon-stimulated genes (ISG) (1)
- interhemispheric inhibition (1)
- internal evidence (1)
- internalization (1)
- intravaginal ring (1)
- invertebrate host (1)
- ion chromatography (1)
- keratinocytes (1)
- ketamine (1)
- ketoreductase (1)
- konsistent (1)
- labour market attachment (1)
- lake-level fluctuations (1)
- land use and land cover change (1)
- lipase (1)
- lipid mediator (1)
- lipid metabolism (1)
- lipids (1)
- literature (1)
- liver disease (1)
- mQTL (1)
- mTHPC (1)
- mTORC1 (1)
- magic number (1)
- mast (1)
- mathematical modeling (1)
- maximum performance (1)
- meaning in life (1)
- medical ethics (1)
- membrane transporters (1)
- menstrual cycle (1)
- mental illness (1)
- messianic tradition (1)
- metabolite (1)
- metabolites (1)
- miRNA (1)
- miR‐21 (1)
- microbial diversity (1)
- microbial function (1)
- microbiota (1)
- microcore (1)
- microglia (1)
- microwave (1)
- mitochondrial respiration (1)
- mixed-valence correlations (1)
- mixture proposals (1)
- modeling (1)
- modernisation (1)
- molecular ion formation (1)
- morphology (1)
- mortality costs (1)
- motility (1)
- multidrug resistance (1)
- multiview geometry (1)
- mutation correction (1)
- myocardial infarction (1)
- mystical prayer (1)
- nasopharynx (1)
- necrosis (1)
- negative ions (1)
- nephrotoxicity (1)
- neuroblastoma (1)
- neuroendocrine (1)
- neuron-rich calcium isotopes (1)
- neuroplasticity (1)
- nightglow (1)
- nitrate (1)
- nitrite (1)
- non-equilibrium (1)
- non-invasive genetics (1)
- non-thermal plasma (1)
- novel (1)
- obesity (1)
- oil (1)
- oligodendrocyte precursor cells (1)
- oligomeric proanthocyanidines (1)
- oral contraceptives (1)
- orbital injury (1)
- organic cation transporter 2 (1)
- overflow metabolites (1)
- oxidativer Stress (1)
- oxygen (1)
- parentage assignment (1)
- parental leave (1)
- parental pressure (1)
- parental support (1)
- parotid gland (1)
- particle tracking (1)
- passive acoustic monitoring (1)
- penta-acylated lipid A (1)
- perfusion measurements (1)
- periodontal disease (1)
- permeabilizer (1)
- personalized medicine (1)
- pharmacological chaperone (1)
- phenotypic plasticity (1)
- photodynamic therapy (1)
- physical activity (1)
- pig (1)
- pig model (1)
- plasma diagnostic (1)
- plasma medicine (1)
- plasma sheaths (1)
- plasma-treated water (1)
- pollen analysis (1)
- polytrauma (1)
- population‐based study (1)
- practice-based evidence (1)
- precision mass measurements (1)
- prediabetic state (1)
- prediction modelling (1)
- predictors (1)
- prevention (1)
- pro-environmental behaviors (1)
- pro-environmental ideology (1)
- progesterone (1)
- prognostic factors (1)
- protein abundance (1)
- protein engineering (1)
- protein expression (1)
- pulmonary arterial hypertension (1)
- pulmonary hypertension (1)
- pyruvate (1)
- pyruvate kinase (1)
- quality of life (1)
- random mutagenesis (1)
- random noise stimulation (1)
- randomization (1)
- randomized controlled trial (1)
- range expansion (1)
- reactivity (1)
- reappraisal (1)
- recombinant protein (1)
- regenerative medicine (1)
- regression analysis (1)
- rehabilitation (1)
- remote (1)
- remote sensing (1)
- renin-angiotensin system (1)
- retrieval (1)
- riociguat (1)
- salinity changes (1)
- saliva (1)
- salivary tracer technique (1)
- sample storage (1)
- seasonal survival (1)
- secondary electron emission (1)
- secondary school (1)
- secularisation (1)
- seizure (1)
- seizures (1)
- semantic network (1)
- semi-empirical (1)
- sensitivity (1)
- sensory impairments (1)
- sex differences (1)
- sex ratio (1)
- short-lived nuclides (1)
- single nucleotide polymorphisms (1)
- site selection (1)
- small cell numbers (1)
- small mammals (1)
- snoD mutant (1)
- social cognition (1)
- social distance (1)
- social evidence (1)
- soil proteins (1)
- sozio-emotionale Stärken und Schwächen (1)
- spark discharges (1)
- sphingomyelin (1)
- spiders (1)
- spp. (1)
- stem cells (1)
- stereoscopy (1)
- stigma (1)
- structure-activity (1)
- sub-ambient temperature (1)
- subcritical fluid chromatography (1)
- subgroup analysis (1)
- substituent (1)
- supercritical CO<sub>2</sub> (1)
- suppression (1)
- surface double layer (1)
- survival (1)
- survival analysis (1)
- sustainable aquaculture (1)
- symbiosis (1)
- synthesis (1)
- systematics (1)
- systems biology (1)
- tPMP resistance (1)
- tannic acid degradation pathway (1)
- tannin catabolism (1)
- tap water (1)
- task dependency (1)
- taxonomy (1)
- telemetry (1)
- tephra layers (1)
- time-resolved optical emission spectroscopy (1)
- toll-like receptor 4 (1)
- trade-off (1)
- trajectory analysis (1)
- trans dimensional sampling (1)
- transcranial direct current stimulation (1)
- transcranial electrical stimulation (1)
- transcript (1)
- transcript analyses (1)
- transcriptomics (1)
- transmission (1)
- transporters (1)
- treatment planning (1)
- tree-rings (1)
- trinucleotide building block (1)
- tropical forests (1)
- tumours (1)
- type I IFN response (1)
- unfolded protein response (1)
- unsolicited mental health diagnosis (1)
- urinary exosomes (1)
- utilitarianism (1)
- vagus nerve (1)
- value chains (1)
- variant of unknown significance (1)
- varves (1)
- vector (1)
- virology (1)
- virulence (1)
- virus (1)
- virus discovery (1)
- virus-host interaction (1)
- vision loss (1)
- voltage stabilization (1)
- warm glow (1)
- willingness to sacrifice (1)
- wood anatomy (1)
- xylogenesis (1)
- Übersättigung (1)
- Überwachtes Lernen (1)
- Überwinterung (1)
- ‘Little Ice Age’ (LIA) (1)
Institute
- Abteilung für Mikrobiologie und Molekularbiologie (19)
- Institut für Biochemie (16)
- Institut für Geographie und Geologie (16)
- Institut für Physik (14)
- Institut für Pharmazie (13)
- Institut für Botanik und Landschaftsökologie & Botanischer Garten (10)
- Interfakultäres Institut für Genetik und Funktionelle Genomforschung (MNF) (10)
- Kliniken und Polikliniken für Innere Medizin (10)
- Zoologisches Institut und Museum (10)
- Klinik und Poliklinik für Neurologie (8)
Publisher
- MDPI (53)
- Frontiers Media S.A. (29)
- S. Karger AG (20)
- Copernicus (12)
- SAGE Publications (11)
- Wiley (9)
- Public Library of Science (PLoS) (7)
- BioMed Central (BMC) (4)
- De Gruyter (4)
- Nature Publishing Group (4)
Vielfältig lässt sich die Bedeutung von Vorstrafen zeigen; jenseits ihrer gesellschaftlichen Wirkungen beschäftigen sie Straf-, Arbeits- und Zivilgerichte. Dieser Beitrag untersucht, welche Implikationen die Registrierung einer Verurteilung hat. Dabei soll aus strafrechtlicher wie auch aus grundrechtlicher Perspektive belegt werden, dass der Staat als Autor der Verurteilung alle ihre Folgen bedenken und bestimmten Konsequenzen gegebenenfalls entgegenwirken muss. Zur Einstimmung sollen fünf Fallskizzen Schlaglichter auf den Problemkreis werfen:
AbstractThis paper takes concepts from spatial theory and globalization discourse and uses them in order to analyze the narrative function of descriptions of nature in romantic Icelandic poetry from the beginning of the 19th century and an Icelandic TV-Series from 2015. In Iceland’s romantic poetry of the early 19th century, especially in poems written by Bjarni Thorarensen, sublime nature is described as a form of guardian against foreign influences that threaten the way of living on the peripheral island. This romantic concept of Icelandic nature is closely connected to narrative patterns in the process of the Icelandic Nation-Building, as it characterizes Icelanders as simultaneously defined and protected by the harsh conditions on the island. The paper takes a comparative look at the underlying narrative concepts of nature in two of Bjarni Thorarensen’s poems and a recent Icelandic TV series, Baltasar Kormákur’s Ófærð (2015), that presents a different concept of Icelandic nature in its relation to a (threatening) global influence. The series depicts a globalized world in which crime does not only affect remote communities as an evil from the outside but as a local evil connected to forces on global scale. Nature as a narrative device in the TV series thus does not protect Icelanders from global forces, as it did in Bjarni Thorarensens poems in the early 19th century, but instead functions a catalyst that reveals the evil from the outside and the evil from within.
Determination of the Pathological Features of NPC1 Variants in a Cellular Complementation Test
(2019)
Niemann-Pick Type C (NP-C) is a rare disorder of lipid metabolism caused by mutations
within the NPC1 and NPC2 genes. NP-C is a neurovisceral disease leading to a heterogeneous,
multisystemic spectrum of symptoms in those affected. Until now, there is no investigative tool to
demonstrate the significance of single variants within the NPC genes. Hence, the aim of the study
was to establish a test that allows for an objective assessment of the pathological potential of NPC1
gene variants. Chinese hamster ovary cells defective in the NPC1 gene accumulate cholesterol in
lysosomal storage organelles. The cells were transfected with NPC1-GFP plasmid vectors carrying
distinct sequence variants. Filipin staining was used to test for complementation of the phenotype.
The known variant p.Ile1061Thr showed a significantly impaired cholesterol clearance after 12 and
24 h compared to the wild type. Among the investigated variants, p.Ser954Leu and p.Glu1273Lys
showed decelerated cholesterol clearance as well. The remaining variants p.Gln60His, p.Val494Met,
and p.Ile787Val showed a cholesterol clearance indistinguishable from wild type. Further, p.Ile1061Thr
acquired an enhanced clearance ability upon 25-hydroxycholesterol treatment. We conclude that the
variants that caused an abnormal clearance phenotype are highly likely to be of clinical relevance.
Moreover, we present a system that can be utilized to screen for new drugs.
GPR68 (OGR1) belongs to the proton-sensing G protein-coupled receptors that are involved
in cellular adaptations to pH changes during tumour development. Although expression of GPR68
has been described in many tumour cell lines, little is known about its presence in human tumour
entities. We characterised the novel rabbit monoclonal anti-human GPR68 antibody 16H23L16
using various cell lines and tissue specimens. The antibody was then applied to a large series of
formalin-fixed, paraffin-embedded normal and neoplastic human tissue samples. Antibody specificity
was demonstrated in a Western blot analysis of GPR68-expressing cells using specific siRNAs.
Immunocytochemical experiments revealed pH-dependent changes in subcellular localisation of the
receptor and internalisation after stimulation with lorazepam. In normal tissue, GPR68 was present in
glucagon-producing islet cells, neuroendocrine cells of the intestinal tract, gastric glands, granulocytes,
macrophages, muscle layers of arteries and arterioles, and capillaries. GPR68 was also expressed
in neuroendocrine tumours, where it may be a positive prognostic factor, in pheochromocytomas,
cervical adenocarcinomas, and endometrial cancer, as well as in paragangliomas, medullary thyroid
carcinomas, gastrointestinal stromal tumours, and pancreatic adenocarcinomas. Often, tumour
capillaries were also strongly GPR68-positive. The novel antibody 16H23L16 will be a valuable tool for
basic research and for identifying GPR68-expressing tumours during histopathological examinations.
Renal drug transporters such as the organic cation transporters (OCTs), organic anion
transporters (OATs) and multidrug resistance proteins (MRPs) play an important role in the tubular
secretion of many drugs influencing their efficacy and safety. However, only little is known about
the distinct protein abundance of these transporters in human kidneys, and about the impact of
age and gender as potential factors of inter-subject variability in their expression and function.
The aim of this study was to determine the protein abundance of MDR1, MRP1-4, BCRP, OAT1-3,
OCT2-3, MATE1, PEPT1/2, and ORCTL2 by liquid chromatography-tandem mass spectrometry-based
targeted proteomics in a set of 36 human cortex kidney samples (20 males, 16 females; median age
53 and 55 years, respectively). OAT1 and 3, OCT2 and ORCTL2 were found to be most abundant
renal SLC transporters while MDR1, MRP1 and MRP4 were the dominating ABC transporters.
Only the expression levels of MDR1 and ORCTL2 were significantly higher abundant in older donors.
Moreover, we found several significant correlations between different transporters, which may
indicate their functional interplay in renal vectorial transport processes. Our data may contribute to
a better understanding of the molecular processes determining renal excretion of drugs.
Salivary glands provide secretory functions, including secretion of xenobiotics and among
them drugs. However, there is no published information about protein abundance of drug transporters
measured using reliable protein quantification methods. Therefore, mRNA expression and absolute
protein content of clinically relevant ABC (n = 6) and SLC (n = 15) family member transporters in the
human parotid gland, using the qRT-PCR and liquid chromatography-tandem mass spectrometry
(LC−MS/MS) method, were studied. The abundance of nearly all measured proteins ranged between
0.04 and 0.45 pmol/mg (OCT3 > MRP1 > PEPT2 > MRP4 > MATE1 > BCRP). mRNAs of ABCB1,
ABCC2, ABCC3, SLC10A1, SLC10A2, SLC22A1, SLC22A5, SLC22A6, SLC22A7, SLC22A8, SLCO1A2,
SLCO1B1, SLCO1B3 and SLCO2B1 were not detected. The present study provides, for the first time,
information about the protein abundance of membrane transporters in the human parotid gland,
which could further be used to define salivary bidirectional transport (absorption and secretion)
mechanisms of endogenous compounds and xenobiotics.
Determining the effect of a changing climate on tree growth will ultimately depend on our understanding of wood formation processes and how they can be affected by environmental conditions. In this context, monitoring intra-annual radial growth with high temporal resolution through point dendrometers has often been used. Another widespread approach is the microcoring method to follow xylem and phloem formation at the cellular level. Although both register the same biological process (secondary growth), given the limitations of each method, each delivers specific insights that can be combined to obtain a better picture of the process as a whole. To explore the potential of visualizing combined dendrometer and histological monitoring data and scrutinize intra-annual growth data on both dimensions (dendrometer → continuous; microcoring → discrete), we developed DevX (Dendrometer vs. Xylogenesis), a visualization application using the “Shiny” package in the R programming language. The interactive visualization allows the display of dendrometer curves and the overlay of commonly used growth model fits (Gompertz and Weibull) as well as the calculation of wood phenology estimates based on these fits (growth onset, growth cessation, and duration). Furthermore, the growth curves have interactive points to show the corresponding histological section, where the amount and development stage of the tissues at that particular time point can be observed. This allows to see the agreement of dendrometer derived phenology and the development status at the cellular level, and by this help disentangle shrinkage and swelling due to water uptake from actual radial growth. We present a case study with monitoring data for Acer pseudoplatanus L., Fagus sylvatica L., and Quercus robur L. trees growing in a mixed stand in northeastern Germany. The presented application is an example of the innovative and easy to access use of programming languages as basis for data visualization, and can be further used as a learning tool in the topic of wood formation and its ecology. Combining continuous dendrometer data with the discrete information from histological-sections provides a tool to identify active periods of wood formation from dendrometer series (calibrate) and explore monitoring datasets.
Formation of singly and doubly charged Arq+ and Tiq+ (q = 1,2) and of molecular Ar 2 +, ArTi+, and Ti 2 + ions in a direct current magnetron sputtering discharge with a Ti cathode and argon as working gas was investigated with the help of energy-resolved mass spectrometry. Measured ion energy distributions consist of low-energy and high-energy components resembling different formation processes. Intensities of Ar 2 + and ArTi+ dimer ions strongly increase with increasing gas pressure. Addition of oxygen gas leads to the formation of positively charged O+, O2 +, and TiO+ and of negatively charged O− and O2 - ions.
Abstract
We propose a setup enabling electron energy loss spectroscopy to determine the density of the electrons accumulated by an electropositive dielectric in contact with a plasma. It is based on a two-layer structure inserted into a recess of the wall. Consisting of a plasma-facing film made out of the dielectric of interest and a substrate layer, the structure is designed to confine the plasma-induced surplus electrons to the region of the film. The charge fluctuations they give rise to can then be read out from the backside of the substrate by near specular electron reflection. To obtain in this scattering geometry a strong charge-sensitive reflection maximum due to the surplus electrons, the film has to be most probably pre-n-doped and sufficiently thin with the mechanical stability maintained by the substrate. Taking electronegative CaO as a substrate layer we demonstrate the feasibility of the proposal by calculating the loss spectra for Al2O3, SiO2, and ZnO films. In all three cases we find a reflection maximum strongly shifting with the density of the surplus electrons and suggest to use it for charge diagnostics.
Abstract
Reactive high power impulse magnetron sputtering (HiPIMS) of a cobalt cathode in pure argon gas and with different oxygen admixtures was investigated by time-resolved optical emission spectroscopy (OES) and time-integrated energy-resolved mass spectrometry. The HiPIMS discharge was operated with a bipolar pulsed power supply capable of providing a large negative voltage with a typical pulse width of 100 μs followed by a long positive pulse with a pulse width of about 350 μs. The HiPIMS plasma in pure argon is dominated by Co+ ions. With the addition of oxygen, O+ ions become the second most prominent positive ion species. OES reveals the presence of Ar I, Co I, O I, and Ar II emission lines. The transition from an Ar+ to a Co+ ion sputtering discharge is inferred from time-resolved OES. The enhanced intensity of excited Ar+* ions is explained by simultaneous excitation and ionisation induced by energetic secondary electrons from the cathode. The intensity of violet Ar I lines is drastically reduced during HiPIMS. Intensity of near-infrared Ar I lines resumes during the positive pulse indicating an additional heating mechanism.