Refine
Year of publication
Document Type
- Doctoral Thesis (131)
- Article (88)
Has Fulltext
- yes (219)
Is part of the Bibliography
- no (219)
Keywords
- - (47)
- Biopharmazie (17)
- Wirkstofffreisetzung (14)
- Pharmazeutische Technologie (10)
- In vitro (8)
- Gastrointestinaltrakt (7)
- Bacillus (6)
- Cytotoxizität (6)
- Magen (6)
- Feste Arzneiform (5)
- Glutathionperoxidase (5)
- Organische Synthese (5)
- antibiotic resistance (5)
- biorelevant dissolution (5)
- in vitro (5)
- Apoptose (4)
- Bacillus licheniformis (4)
- Bakterien (4)
- ESBL (4)
- In vivo (4)
- Pharmazie (4)
- Plasma (4)
- Polymere (4)
- Polysaccharide (4)
- Zellkultur (4)
- drug release (4)
- drug resistance (4)
- 3D-Druck (3)
- Atmosphärendruckplasma (3)
- Bacillus subtilis (3)
- Biorelevante Wirkstofffreisetzung (3)
- Dünndarm (3)
- Enzyminhibitor (3)
- Epigenetik (3)
- Glaskörper (3)
- HPLC (3)
- In vitro-Modell (3)
- Magenentleerung (3)
- Naturstoff (3)
- Oxidativer Stress (3)
- Photochemie (3)
- Plasmamedizin (3)
- Proteomics (3)
- antimicrobial resistance (3)
- broiler (3)
- flupirtine (3)
- hydrogel (3)
- inhibition (3)
- retigabine (3)
- salivary tracer technique (3)
- <i>E. coli</i> (2)
- Antimicrobial resistance (2)
- Autophagie (2)
- Biotechnologie (2)
- Cyanobakterien (2)
- Drug-eluting Stent (2)
- E. coli (2)
- Escherichia coli (2)
- Extrakt (2)
- Flupirtin (2)
- Flupirtine (2)
- Fused Deposition Modeling (2)
- HPMC (2)
- Hepatotoxicity (2)
- Heterologe Genexpression (2)
- Immunsystem (2)
- Immuntoxizität (2)
- In-vitro-Kultur (2)
- Jurkat (2)
- KCNQ (2)
- Keratinozyt (2)
- Kernspintomografie (2)
- Ketamin (2)
- Krebszelle (2)
- MRT (2)
- Metacyclophane (2)
- MimiCol (2)
- Molekularbiologie (2)
- Mukoadhäsion (2)
- One Health (2)
- Patient (2)
- Pentathiepine (2)
- Pharmakokinetik (2)
- Pharmazeutische Chemie (2)
- Phytochemie (2)
- Platin (2)
- Proteom (2)
- Retigabin (2)
- Stabilität (2)
- Stent (2)
- Stoffwechselphysiologie (2)
- THP-1 (2)
- Tablette (2)
- Toxizität (2)
- Transkriptom (2)
- Wirkstoffverteilung (2)
- Wundheilung (2)
- Zellzyklus (2)
- Zytotoxizität (2)
- aerogel (2)
- anti-biofilm (2)
- antibacterial (2)
- anticancer drug (2)
- antimicrobial photodynamic therapy (2)
- apoptosis (2)
- biofilm (2)
- biological activities (2)
- biorelevant in vitro model (2)
- biorelevante Wirkstofffreisetzung (2)
- bolaform amphiphilic lipids (2)
- bolalipids (2)
- caffeine (2)
- celecoxib (2)
- cell cycle (2)
- chorioallantoic membrane model (2)
- colonic microbiota (2)
- cytotoxicity (2)
- diclofenac (2)
- drug delivery system (2)
- dynamic colon model (2)
- efavirenz (2)
- fenofibrate (2)
- feste Arzneiformen (2)
- gastric emptying (2)
- hot melt extrusion (2)
- in vitro metabolization (2)
- in vivo (2)
- ketamine (2)
- magnetic marker monitoring (2)
- metabolic engineering (2)
- metaproteomics (2)
- molecular docking (2)
- motility (2)
- nanoemulsion (2)
- natural products (2)
- one health (2)
- oxidative stress (2)
- oxylipins (2)
- proteomics (2)
- self-assembly (2)
- solid oral dosage forms (2)
- stomach (2)
- structure activity (2)
- sulfasalazine (2)
- supercritical fluid chromatography (2)
- synthesis (2)
- virulence (2)
- -anethole (1)
- 1,2,3-benzotriazoles (1)
- 1,2,4-triazoles (1)
- 1048715485 (1)
- 16S rRNA Gensequence (1)
- 2,4-diamino-1,3,5-triazines (1)
- 2-imino-2<i>H</i>-chromen-3-yl-1,3,5-triazines (1)
- 2-imino-coumarins (1)
- 2<i>H</i>-chromen-3-yl-1,3,5-triazines (1)
- 3-> (1)
- 3D printing (1)
- 3D-QSAR (1)
- 3D-printing (1)
- 4010153-8 (1)
- 4070959-0 (1)
- 4274237-7 (1)
- 4628922-7 (1)
- 5637 (1)
- 5‐lipoxygenase (1)
- 7651795-0 (1)
- <i>Enterobacteriaceae</i> (1)
- <i>Lannea barteri</i> (1)
- <i>N</i>-acylhydrazones (1)
- <i>N</i>-sulfonylhydrazones (1)
- A549 (1)
- ABC-Transporter (1)
- ADMET analysis (1)
- AMR (1)
- APJ (1)
- Aborigines (1)
- Absorption (1)
- Acetate (1)
- Acetoin (1)
- Acylhydrazone (1)
- Adenylylcyclase (1)
- Aerobes Wach (1)
- Aerosol (1)
- Agaritin (1)
- Alkylierung (1)
- Alkylresorcinole (1)
- Allergie (1)
- Alzheimer’s disease (1)
- AmpC (1)
- Amylase (1)
- Analytik (1)
- Analytische Chemie (1)
- Antarktis (1)
- Anti-adhesive (1)
- Antibiotic Stewardship (1)
- Antibiotikaresistenz (1)
- Antibiotikum (1)
- Antifungals (1)
- Antigenität (1)
- Antimicrobial (1)
- Antimikrobiel (1)
- Antimikrobielle Aktivität (1)
- Antimykotika (1)
- Apelin (1)
- Apoptosis (1)
- Armillaria ostoyae (1)
- Arzneiform (1)
- Arzneimittel-bezogenes Problem (1)
- Arzneimitteldesign (1)
- Arzneimittelnebenwirkung (1)
- Arzneimittelrückstand (1)
- Arzneimitteltransport (1)
- Arzneimitteltransporter (1)
- Arzneistofffreisetzende Stents (1)
- Arzneistoffmetabolismus (1)
- At-line Monitoring (1)
- At-line monitoring (1)
- Atropa belladonna (1)
- Atropin (1)
- Auge (1)
- Augenbewegung (1)
- Autophagocytose (1)
- Autophagy (1)
- Axenization (1)
- Azobenzene (1)
- Azofarbstoffe (1)
- BCL11B (1)
- Bacillus cereus (1)
- Bacterial virulence (1)
- Balticidin (1)
- Bathymodiolus (1)
- Bathymodiolus symbiosis (1)
- Benzimidazolderivate (1)
- Beschichtung (1)
- Bestimmung Arzneistoffkonzentration (1)
- Bicarbonate (1)
- Bioavailability (1)
- Biochemie (1)
- Biochip (1)
- Bioinformatics (1)
- Bioinformatik (1)
- Biology and Natural Sciences (1)
- Biom (1)
- Biopharmacy (1)
- Biorefinery process (1)
- Biorelevant (1)
- Biorelevante Freisetzung (1)
- Biotransformation (1)
- Bioverfahrenstechnik (1)
- Brown-Relaxation (1)
- CAM (1)
- CAZymes (1)
- CCHC zinc finger (1)
- CD-Spektroskopie (1)
- CTX-M-1 (1)
- Caco-2 (1)
- Calvatia gigantea (1)
- Carbamidocyclophane (1)
- Cellulose (1)
- Centaurothamnus maximus (1)
- Chaperonin (1)
- Charakterisierung (1)
- Chelate (1)
- Chemische Analyse (1)
- Chinin (1)
- Chinolin (1)
- Chlorella vulgaris (1)
- Chromatographie (1)
- Cisplatin (1)
- Co-selection (1)
- Coating (1)
- Codakia orbicularis (1)
- Compatibility (1)
- Cyanbacteria (1)
- Cyanobacteria (1)
- Cyanonacteria (1)
- Cylindrocyclophane (1)
- Cylindrospermum (1)
- Cytochrom P-450 (1)
- Cytotoxic (1)
- DFT (1)
- DNA (1)
- DNA immunization (1)
- DNA-Immunisierung (1)
- DNA-Schädigung (1)
- DNA–DNA hybridization (ddH) (1)
- DNS (1)
- DUOCAP (1)
- Deep-sea hydrothermal vents (1)
- Dekontamination (1)
- Delphi-Technik (1)
- Depression (1)
- Diabetes (1)
- Dickdarm (1)
- Diclofenac (1)
- Diffusion (1)
- Dioxindolderivat (1)
- Dissolution/Six Solutions (1)
- Drosera intermedia (1)
- Drosera rotundifolia (1)
- Drug release (1)
- Drug stability (1)
- Drug-Targeting (1)
- EGFR (1)
- EGFR inhibitor (1)
- EGFR-mutated (1)
- EMP-hybrid (1)
- EMT (1)
- ESBL – (1)
- ESBL- (1)
- ESBL/AmpC- (1)
- ESBL— (1)
- ESKAPE strain (1)
- Elastase inhibitions (1)
- Elastase inhibitor (1)
- Elastase inhibitoren (1)
- Electrical chip (1)
- Endothel (1)
- Enhanced Sampling (1)
- Entladung (1)
- Entropie (1)
- Enzyminhibition (1)
- Epidermaler Wachstumsfaktor-Rezeptor (1)
- Equiden (1)
- Erkrankungen der Speiseröhre (1)
- Ethinylestradiol (1)
- Ethiopia (1)
- Ethnomedizin (1)
- Etonogestrel (1)
- Expression system (1)
- Extended-Spectrum Beta-Lactamase (1)
- Extrakorporale Dialyse (1)
- Extraktion (1)
- Eye Movement System (EyeMoS) (1)
- EyeFlowCell (1)
- EyeMovementSystem (1)
- FDM (1)
- Fed batch (1)
- Fed-batch-Verfahren (1)
- Feed supplementation (1)
- Fermentation (1)
- Film (1)
- Fische (1)
- Flavobacteria (1)
- Fluidized-bed technology (1)
- Flüssigkeiten (1)
- Fomitopsis betulina (1)
- Food effect (1)
- Freisetzung (1)
- Funktionalisierung <Chemie> (1)
- Fällung (1)
- GC-MS (1)
- GPx1 knockout (1)
- Gastro-Intestinal Passage von Arznei (1)
- GastroDuo (1)
- Gastrointestinaler Transit (1)
- Gastroretention (1)
- Gastroretentive Arzneiform (1)
- Gatrointestinaltrakt (1)
- Gefäß-simulierende Durchflusszelle (1)
- Genexpression (1)
- Gentechnologie (1)
- Gerbstoff (1)
- Germany (1)
- Geschmack (1)
- Gewebemodelle (1)
- Glaskörper-Modell (GK-Modell) (1)
- Global protein analysis (1)
- Glucane <beta-1 (1)
- Glucane <beta-1,3-> (1)
- Glutathion (1)
- Glykokalyx (1)
- Glykoprotein (1)
- Glyoxylat (1)
- Glyoxylatzyklus (1)
- Goldkomplexe (1)
- Green algae (1)
- Gruppendiskussion (1)
- GumbiGumbi (1)
- GumbyGumby (1)
- H. aspersa Müller (1)
- HEK293 (1)
- HaCaT (1)
- Haftkleber (1)
- Hallimasch (1)
- Hauthaftung (1)
- Hautzelle (1)
- HepG2 (1)
- Heparin (1)
- Heparin-induzierte Thrombozytopenie (1)
- Hepatitis B (1)
- Heterocycles (1)
- Heubacillus (1)
- High resolution proteomics (1)
- High-risk clonal lineages (1)
- Histon-Deacetylase (1)
- Histon-Demethylase (1)
- Histon-Demethylierung (1)
- Hitzestress (1)
- Homöopathisches Arzneibuch (1)
- Honig (1)
- Hospital (1)
- Hospitalisierung (1)
- Human interleukin-1β (1)
- Hydrazide (1)
- Hydrocortison (1)
- Hydrogele (1)
- Hydrogencarbonatpuffer (1)
- Hydrothermal vent (1)
- Hydrothermalquelle (1)
- Hydroxyl (1)
- Hydroxylradikale (1)
- Immune system (1)
- Immunisierung (1)
- Immunstimulation (1)
- Immunsuppression (1)
- Implantat (1)
- Implantate (1)
- In vitro Modelle (1)
- In vitro-Freisetzungsmodell (1)
- In vitro-Freisetzungsuntersuchung (1)
- In vivo Methoden (1)
- In-vitro (1)
- IncI1 (1)
- Indonesian marine fungi (1)
- Induktion (1)
- Inhibition (1)
- Injektionssuspensionen (1)
- Instrumentelle Analytik (1)
- Interactome (1)
- Interaktion (1)
- Interaktom (1)
- Interindividuelle Variabilität (1)
- Interventionsmaßnahmen (1)
- Intravitreale Arzneiformen (1)
- Intravitreale Pharmakotherapie (1)
- Isomer (1)
- Jejunum (1)
- K (1)
- KDM4A (1)
- KV7 (1)
- KV7-Kanäle (1)
- KYSE 70 (1)
- Kernrezeptor (1)
- Kernspintomographie (1)
- Klinische Studien (1)
- Klinisches Experiment (1)
- Klonierung (1)
- Kolik (1)
- Kombinatorische Synthese (1)
- Komplementärmedizin (1)
- Konformationsänderungen (1)
- Kontrollierte Wirkstofffreisetzung (1)
- Koronarstent (1)
- Kras-Mutation (1)
- Krebsresistenz (1)
- Krebstherapie (1)
- Kreuzresistenz (1)
- Kultivierung (1)
- Kulturbedingungen (1)
- Kv 7.2/3 channel activators (1)
- Kv7.2/7.3 (1)
- L-SNEDDS (1)
- L. (1)
- Lactobacillus brevis (1)
- Lactobacillus plantarum (1)
- Lactobacillus rossiae (1)
- Lactose (1)
- Langwirksame Kontrazeptiva (1)
- Laparotomie (1)
- Leber (1)
- Legionella (1)
- Legionellen (1)
- Levdopa (1)
- Levonorgestrelbutanoat (1)
- Liposom (1)
- Löslichkeit (1)
- MDR (1)
- MRG (1)
- MRI (1)
- MRI study (1)
- MRSA (1)
- MS (1)
- Magen-Darm-Trakt (1)
- Magenmotilität (1)
- Magenstraße (1)
- Magnet (1)
- Magnetic Drug Targeting (1)
- Magnetic Relaxation Immnoassay (1)
- Magnetic nanoparticles (1)
- Magnetisches Drug Targeting (1)
- Magnetorelaxometry (1)
- Marine Pilze (1)
- Marine fungi (1)
- Marine polysaccharide (1)
- Masthähnchen (1)
- Mathematische Modellierung (1)
- Mechanotransduktion (1)
- Medicinal Chemistry (1)
- Medizinische Chemie (1)
- Medroxyprogesteronacetat (1)
- Mehrdimensionale Chromatographie (1)
- Melanin (1)
- Mercaptobernsteinsäure (1)
- Mesalazin (1)
- Metabolic Engineering (1)
- Metagenomics (1)
- Metagenomik (1)
- Metallkomplexe (1)
- Metaproteomics (1)
- Microarray (1)
- Microbial ecology (1)
- Microbiology (1)
- Mikroalge (1)
- Mikroalgen (1)
- Mikrobiologie (1)
- Mikrobiom (1)
- Mikrobiota (1)
- Mikroorganismen (1)
- Mikrowellensynthese (1)
- MimiCol3 (1)
- MimiCol³ (1)
- Mobilität (1)
- Molecular modeling (1)
- Moleküldynamik (1)
- Molke (1)
- Mongolia (1)
- Morphologie (1)
- Myricaria germanica (1)
- NMR (1)
- NRPS (1)
- NSCLC (1)
- Nahrungsmitteleffekt (1)
- Nanopartikel (1)
- Natürliche Killerzelle (1)
- Nekrose (1)
- Nicht-kleinzelliges Bronchialkarzinom (1)
- Nichtionisches Tensid (1)
- Niedertemperaturplasma (1)
- Non-thermal plasma (1)
- Nostoc (1)
- Nucleotidanaloga (1)
- Nukleoprotein (1)
- Nutztierhaltung (1)
- Onkologie (1)
- Ophthalmologie (1)
- Overproduction (1)
- Oxidation (1)
- Oxidation Potential (1)
- Oxidation potential (1)
- PAR2 (1)
- PBPK (1)
- PKS (1)
- PLK1 inhibitors (1)
- Pancreatitis (1)
- Pankreaskarzinom (1)
- Pankreatitis (1)
- Pantoprazol (1)
- Pappel-Ritterling (1)
- Paracetamol (1)
- Paracyclophane (1)
- Parkinson-Patienten (1)
- Pectat-Lyase (1)
- Pediatric drug product (1)
- Pektinesterase (1)
- Penicillin G, Formulation development, Helicobacter pylori (1)
- Pentathiepin (1)
- Permeabilität (1)
- Permeabilitätskoeffizient (1)
- Petrotoga (1)
- Pferd (1)
- Pharmacokinetics (1)
- Pharmakobezoare (1)
- Pharmazie Greifswald (1)
- Phosphate (1)
- Photoaktivierbarkeit (1)
- Photodynamische Therapie (1)
- Photon Correlation Spetroscopy (1)
- Photopharmakologie (1)
- Photoreduktion (1)
- Photoswitches (1)
- Phytopharmaka (1)
- Pigmentierung (1)
- Pigs (1)
- Pilze (1)
- Pittosporum angustifolium (1)
- Pittosporum-angustifolium (1)
- Plasma medicine (1)
- Plasmachemie (1)
- Plasmaspektroskopie (1)
- Plasmid (1)
- Plasmodium (1)
- Platin-Komplexe (1)
- Platinkomplexe (1)
- Plättchenfaktor 4 (1)
- Polymer (1)
- Polysaccharide utilization (1)
- Poorly soluble drugs (1)
- Precipitation inhibitor (1)
- Pressure Sensitive Adhesives (1)
- Primärtsoffanalytik (1)
- Probe-Tack-Test (1)
- Proliferation (1)
- Protease deficiency (1)
- Protein complexes (1)
- Protein secretion (1)
- Proteinexpression (1)
- Proteinfaltung (1)
- Proteinkomplexe (1)
- Proteomanalyse (1)
- Prozessüberwachung (1)
- Präzipitation (1)
- Pseudoalteromonas (1)
- Pseudosaccharin amines (1)
- Psychrophiler Mikroorganismus (1)
- Pt Komplexe (1)
- Pt complexes (1)
- Pt(II)-Komplexe (1)
- Pylorus (1)
- Pädiatrie (1)
- Pädiatrische Patienten (1)
- Quality-by-Design (1)
- Qualitätskontrolle (1)
- Qualitätssicherung (1)
- Quantifizierung (1)
- R. chamaemorus (1)
- RNA-Seq (1)
- RNS (1)
- ROS (1)
- Rapid Prototyping <Fertigung> (1)
- Rasterkraftmikroskopie (1)
- Reaktivität (1)
- Regenbogenforelle (1)
- Relaxationsmessung (1)
- Replica Exchange (1)
- Reporterenzyme (1)
- Reporterenzymes (1)
- Retention (1)
- Retentionsmechanismen (1)
- Retigabine (1)
- Reversible inhibitions (1)
- Riftia pachyptila (1)
- Rwanda (1)
- SEA (1)
- SFC-MS (1)
- SIRT2 (1)
- SLA 3D-printing (1)
- ST1159 (1)
- Salivary Tracer Technique (1)
- Salzstress (1)
- Sandwich-Hybridisierung (1)
- Sandwich-hybridization (1)
- Sandwichkultivierte Rattenhepatozyten (1)
- Saponine (1)
- Scanning electron microscopy (1)
- Scenedesmus (1)
- Schalteffekte (1)
- Scherstress (1)
- Schluckbare Sensoren (1)
- Schmelzextrusion (1)
- Schwarze Tollkirsche (1)
- Sekundärmetabolit (1)
- Selektivität (1)
- Shigella (1)
- Shockwaves (1)
- SiSo (1)
- Sigma-Rezeptoren (1)
- Signalgeber (1)
- Signaltransduktion (1)
- Simulation (1)
- Sir2-like Proteine (1)
- Sirolimus (1)
- Sirt2 (1)
- Sirtuin (1)
- Sirtuine (1)
- Southern Ocean (1)
- Splitomicin (1)
- Stabilitätsuntersuchungen (1)
- Staphylococcus aureus (1)
- Stickstoffmonoxid-Synthase (1)
- Stilben (1)
- Stresstest (1)
- Strukturaufklärung (1)
- Studie (1)
- Subpopulation (1)
- Substanzinteraktionen (1)
- Sulfanderivate (1)
- SuperPred (1)
- Supercritical fluid chromatography (1)
- SwissTargetPrediction (1)
- Symbiose (1)
- Synergismus (1)
- Synthese (1)
- Systembiologie (1)
- Systems biology (1)
- T-Lymphozyt (1)
- TIGER2h (1)
- TIGER2hs (1)
- Tabletten (1)
- Targeted drug delivery (1)
- Technologie (1)
- Temoporfin (1)
- Tetrahydroindolon (1)
- Tetrazol (1)
- Tetrazole (1)
- Therapie der Speiseröhre (1)
- Thermophile (1)
- Tiopronin (1)
- Tracking (1)
- Transdermales therapeutisches System (1)
- Tricholoma populinum (1)
- Triglyceridabbau (1)
- Triterpenes (1)
- U-5637 (1)
- USP apparatus 4 (1)
- USP apparatus 7 (1)
- UV-Schutz (1)
- UVB (1)
- Ultraviolett B (1)
- Ulvan (1)
- Umkehrphasen-HPLC (1)
- Umweltproteomics (1)
- Urtinktur (1)
- Ussing Kammer (1)
- V (1)
- Vagina (1)
- Vaginale Ringe (1)
- Vaginalringe (1)
- Validierung (1)
- Validität (1)
- Valproinsäure (1)
- Vector flies (1)
- Versorgungsforschung (1)
- Vielfalt (1)
- Virale hämorrhagische Septikämie (1)
- Virulence (1)
- Virulenz (1)
- Wafer (1)
- Wandschubspannung (1)
- Was (1)
- Wasseraufbereitung (1)
- Wiederanheftbarkeit (1)
- Wirbelschichtverfahren (1)
- Wirkstofffreisetzung , Wirkstoff , Löslichkeit , Pharmazie , Forschung , Entwicklung , Formulierung (1)
- Wound healing (1)
- X-ray analysis (1)
- XGND (1)
- Yeast sulfhydryl oxidase (1)
- ZEB1 (1)
- Zellheterogenität (1)
- Zelluläre Heterogenität (1)
- Zinc (1)
- Zirkulardichroismus (1)
- Zunge (1)
- [1,2,4]Triazolo[1,2-a]pyridazine (1)
- accelerated drug release testing (1)
- acetylcholinesterase inhibitors (1)
- acute toxicity (1)
- acylhydrazones (1)
- additive manufacturing (1)
- adenylylcyclase (1)
- adherent human carcinoma cell lines (1)
- adhesion (1)
- advanced oxidation processes (1)
- algicolous fungi (1)
- alkylresorcinols (1)
- allergy (1)
- amides (1)
- amorphous formulations (1)
- amorphous solid dispersion (1)
- anaerobic metabolism (1)
- animal husbandry (1)
- anti-cancer (1)
- anticancer drugs (1)
- antifungal (1)
- antimicrobial activity (1)
- antimicrobial peptides (1)
- antimikrobielle Aktivität (1)
- antimikrobiellen Screening (1)
- antioxidant (1)
- antioxidant activity (1)
- arginine biosynthesis (1)
- ascariasis (1)
- aspiration (1)
- atmospheric pressure plasma (1)
- autophagy (1)
- azo dyes (1)
- bacterial membrane extensions (1)
- beschleunigte Freisetzungstests (1)
- bicarbonate buffer (1)
- biocontrol (1)
- bioenergetics (1)
- biofilm inhibitor (1)
- biological decontamination (1)
- biopharmaceutics (1)
- biorelevant (1)
- biorelevant dissolution stress test device (1)
- biorelevant test conditions (1)
- biorelevante Freisetzung (1)
- biorelevanter Freisetzungstest (1)
- biorelevanter mechanischer Stress (1)
- biosecurity (1)
- biosynthesis gene cluster (BGC) (1)
- bivalve (1)
- bortezomib (1)
- calves (1)
- cancer (1)
- cancer cells (1)
- cancer stem cells (1)
- capsule-in-capsule (1)
- carbamidocyclophanes (1)
- carbon dioxide–based separation (1)
- carbon–carbon lyase (1)
- carboxyesterase (1)
- cattle (1)
- cell proliferation regulating inhibitor of protein phosphatase 2A (1)
- cell signaling (1)
- cell-mediated cytotoxicity (1)
- checkerboard (1)
- chemical synthesis (1)
- chemische Synthese (1)
- chemosynthesis (1)
- chiral resolution (1)
- chiral stationary phase (1)
- clinical chemistry (1)
- clinical study (1)
- coated (1)
- combination with antibiotic (1)
- commensal (1)
- compression-coated tablet (1)
- continuous manufacturing (1)
- control measure (1)
- copolymer (1)
- cormorants (1)
- coronary stent (1)
- coumarins (1)
- culture conditions (1)
- cylindrocyclophanes (1)
- cytotoxic (1)
- cytotoxic activity (1)
- deep sea (1)
- degranulation (1)
- dehydronorketamine (1)
- depression (1)
- dermatophytosis (1)
- determination of drug concentration (1)
- dialysis (1)
- diamine (1)
- diet (1)
- diffusion (1)
- dihydrochalcones (1)
- dissolution (1)
- dissolution method (1)
- dissolution methods (1)
- dissolution stress test (1)
- dissolution testing (1)
- dose dumping (1)
- drucksensitive Arzneiform (1)
- drug delivery (1)
- drug design (1)
- drug distribution (1)
- drug screening (1)
- drug-drug-interaction (1)
- drug-eluting (1)
- drug-eluting stents (1)
- drug-related problem (1)
- drug-targeting (1)
- dynamic simulation (1)
- ease of swallowing (1)
- educast (1)
- educational podcast (1)
- elektrischer Biochip (1)
- environmental epidemiology (1)
- environmental proteomics (1)
- eosinophilic esophagitis (1)
- epidermal growth factor receptor (1)
- epigenetic (1)
- epigenetics (1)
- epigenetik (1)
- esophageal diseases (1)
- esophageal transport (1)
- esophagus (1)
- esophagus therapy (1)
- essentail oils (1)
- essential oil (1)
- essentials elements (1)
- ethnobotany (1)
- ex vivo measurements (1)
- exopolysaccharides (1)
- extended-spectrum beta-lactamases (1)
- extended-spectrum ß-lactamase-producing (1)
- extracellular vesicles (1)
- extractions (1)
- fasted and fed state conditions (1)
- fatty acid (1)
- films (1)
- flavonoids (1)
- flesh (1)
- fluorescent substrates (1)
- fluoreszierende Modellsubstrate (1)
- food chain (1)
- food effects (1)
- food safety (1)
- formulation design (1)
- fungi (1)
- fungicide (1)
- gastric empying (1)
- gastroretention (1)
- gastroretentive dosage form (1)
- gel matrix tablets (1)
- glass transition (1)
- globale Proteinanalyse (1)
- glutathione peroxidase (1)
- glutathione peroxidase-1 (1)
- graphite furnace atomic absorption spectrometry (1)
- helminth (1)
- hepatitis b (1)
- hepatobiliary excretion (1)
- hepatobiliäre Ausscheidung (1)
- heterofermentativ (1)
- high-resolution manometry (1)
- hochauflösende Proteomics (1)
- holobiont (1)
- homodimerization (1)
- homofermentativ (1)
- horse (1)
- host-microbe interactions (1)
- host-symbiont (1)
- hotmelt extrusion (1)
- human intestinal mucosa (1)
- hybrid molecules (1)
- hydrazones (1)
- hydrothermal vent (1)
- hydroxyl radicals (1)
- hydroxynorketamine (1)
- hydroxypropylmethylcellulose (1)
- imaging tools (1)
- imidazo[2,1-<i>c</i>][1,2,4]triazol-3(5<i>H</i>)-imines (1)
- immobilized (1)
- immune response (1)
- immune response stimulation (1)
- implant (1)
- in silico (1)
- in silico Wirkstoffdesign (1)
- in silico target prediction (1)
- in vitro anticancer activity (1)
- in vitro antitumor activity (1)
- in vitro cytotoxic activity (1)
- in vitro dissolution (1)
- in vitro drug release (1)
- in vitro model (1)
- in vitro-Wirkstofffreisetzung (1)
- in vitro–ex vivo correlation (1)
- in vivo disintegration (1)
- in vivo disolution (1)
- in vivo study (1)
- in-vitro (1)
- in-vitro Evaluierung (1)
- individualisierte Wirkstofffreisetzung (1)
- inflammation (1)
- integrative medicine (1)
- interaction (1)
- interactions (1)
- intervention measure (1)
- intervention measures (1)
- intestinal application (1)
- intestinal microdialysis (1)
- intestinal nematode (1)
- intestinale Mikrodialyse (1)
- intraluminal use (1)
- intraluminale Anwendung (1)
- intramuskulär (1)
- intravaginal ring (1)
- intravitreal implants (1)
- intravitreal injection (1)
- intravitreale Wirkstofffreisetzung und -verteilung (1)
- ion channels (1)
- isoprenoid degradation (1)
- isotherme Titrationskalorimetrie (1)
- keratinocyte (1)
- keratinocytes (1)
- kurstakin (1)
- leaf (1)
- lectin (1)
- lethal dose 50 (1)
- lipid mediator (1)
- lipid mediators (1)
- lipopeptide (1)
- local drug targeting (1)
- mRNA detection (1)
- mRNA-Detektion (1)
- mRNA-Stabilität (1)
- mRNA-stability (1)
- mTHPC (1)
- magnetic resonance imaging (1)
- management measures (1)
- manufacturing science (1)
- marine bacteria (1)
- marinen Pilze (1)
- materials science (1)
- medicinal herbs (1)
- medicinal plants (1)
- metabolic interactions (1)
- metabolic processes (1)
- metabolism (1)
- metabolites (1)
- metabolom (1)
- metabolome (1)
- metagenome (1)
- metaproteome (1)
- miR-205-5p (1)
- miRNA (1)
- microbial community (1)
- microbiota (1)
- mikrobielle Gemeinschaft (1)
- mini tablets (1)
- mitochondria (1)
- mobile learning (1)
- modeling (1)
- modified release dosage forms (1)
- molecular modelling (1)
- molecular weight (1)
- monocytes (1)
- monoterpene (1)
- mucoadhesion (1)
- mucoadhesive films (1)
- mucoadhesive polymer (1)
- multicomponent mixtures (1)
- multidrug resistant (1)
- mushrooms (1)
- nanoemulgel (1)
- naphthoquinones (1)
- necrosis (1)
- neutrophils (1)
- next-generation sequencing (1)
- nicotinamide (1)
- non-small cell lung cancer (1)
- nucleotide analogues (1)
- nutrients elements (1)
- oncology (1)
- online sample preparation (1)
- oral application (1)
- oral biopharmacy (1)
- orale Applikation (1)
- orale Bioverfügbarkeit (1)
- organic farming (1)
- orodispersible (1)
- oxidativer Stress (1)
- p53-Mutation (1)
- patient specific in vitro models (1)
- patientenspezifische Wirkstofffreisetzung (1)
- pectinase psychrophilic pseudoalteromonas haloplanktis ANT/505 (1)
- pediatrics (1)
- performance assessment (1)
- pericular injection (1)
- peristalsis (1)
- permeability coefficient (1)
- pharmaceutical care (1)
- pharmacokinetics (1)
- pharmacy education (1)
- pharmacy students (1)
- pharmazeutische Betreuung (1)
- phenolic compounds (1)
- photoactivity (1)
- photodynamic therapy (1)
- photopharmacology (1)
- photoswitches (1)
- phylogenetic analysis (1)
- phylogenomics (1)
- physicochemical characterization (1)
- phytochemicals (1)
- phytochemistry (1)
- phytotherapy (1)
- pig (1)
- plant growth promotion (PGP) (1)
- plasma (1)
- plasma diagnostics (1)
- platelets (1)
- platinum complexes (1)
- platinum-complexes (1)
- podcast (1)
- polypharmacology (1)
- polysaccharide degradation (1)
- poorly soluble drug (1)
- poorly soluble drugs (1)
- porcine small intestine (1)
- posttranslational modification (PTM) (1)
- poultry (1)
- predictive dissolution testing (1)
- pressure-sensitive dosage form (1)
- prolonged release tablet (1)
- propranolol HCl (1)
- protein expression (1)
- protein folding (1)
- protein-protein docking (1)
- prädiktive Freisetzungstests (1)
- public health (1)
- pulse oximetry (1)
- pylorus (1)
- quality assurance (1)
- quality control (1)
- quercetin (1)
- quinolines (1)
- rainbow trout (1)
- reactive oxygen species (1)
- reaktive Schwefelspezies (1)
- regulatory gene (1)
- replica-exchange molecular dynamics (1)
- resistance (1)
- resistome (1)
- respiration (1)
- ring-opening reactions (1)
- rotating magnetic field (1)
- saliva (1)
- saliva flow (1)
- salivary tracer (1)
- sandwich-cultured rat hepatocytes (1)
- scintigraphy (1)
- setups (1)
- sigma-receptors (1)
- silver nanoparticles (1)
- sirtuins (1)
- site-specific application (1)
- site-specific drug delivery (1)
- slaughterhouse (1)
- solubility enhancement, drug delivery, oral administration, SNEDDS, nanoemulsions, polymer, adsorption, celecoxib, efavirenz, fenofibrate (1)
- spark discharges (1)
- spinning process (1)
- spread (1)
- stability studies (1)
- staphylococcal enterotoxin gene (1)
- staphylococcal enterotoxins (1)
- stem bark (1)
- stent (1)
- stomach road (1)
- structure (1)
- structure-activity relationships (1)
- sub-ambient temperature (1)
- subcritical fluid chromatography (1)
- substituent (1)
- sulfonamides (1)
- supercomplexes (1)
- supercritical CO<sub>2</sub> (1)
- supercritical fluid extraction (1)
- surface modification (1)
- symbiosis (1)
- tannins and flavonoids (1)
- tannins and flavonoids; anti-biofilm; E. coli; Epilobium; Filipendula; R. chamaemorus; biological activities; ethnobotany (1)
- taste (1)
- telemetric capsules (1)
- tensile studies (1)
- terbinafine hydrochloride (1)
- texture analysis (1)
- thioureas (1)
- thumolycin (1)
- transcriptome (1)
- triamcinolone acetonide (1)
- upconversion (1)
- ureas (1)
- urine test strips (1)
- user perspective (1)
- vaginal rings (1)
- validation (1)
- vent (1)
- vessel-simulating flow-through cell (1)
- viral hemorrhagic septicaemia virus (1)
- virtual screening (1)
- virulence factors (1)
- vitreous substitute (1)
- wastewater (1)
- weinende Steinlinde (1)
- whole-genome sequencing (1)
- wild birds (1)
- wild boar (1)
- wild ruminant (1)
- wildlife (1)
- wound healing (1)
- xGND (1)
- zellvermittelte Zytotoxizität (1)
- zytotoxische Aktivität (1)
- (1)
- Ökologie (1)
- Übersättigung (1)
Institute
- Institut für Pharmazie (219) (remove)
Publisher
- MDPI (60)
- Wiley (11)
- Frontiers Media S.A. (7)
- BioMed Central (BMC) (5)
- Springer Nature (4)
- ACS Publications (1)
KV7 channel openers have proven their therapeutic value in the treatment of pain as well as epilepsy and, moreover, they hold the potential to expand into additional indications with unmet medical needs. However, the clinically validated but meanwhile discontinued KV7 channel openers flupirtine and retigabine bear an oxidation‐sensitive triaminoraryl scaffold, which is suspected of causing adverse drug reactions via the formation of quinoid oxidation products. Here, we report the design and synthesis of nicotinamide analogs and related compounds that remediate the liability in the chemical structure of flupirtine and retigabine. Optimization of a nicotinamide lead structure yielded analogs with excellent KV7.2/3 opening activity, as evidenced by EC50 values approaching the single‐digit nanomolar range. On the other hand, weighted KV7.2/3 opening activity data including inactive compounds allowed for the establishment of structure–activity relationships and a plausible binding mode hypothesis verified by docking and molecular dynamics simulations.
The polysaccharide β-mannan, which is common in terrestrial plants but unknown in microalgae, was recently detected during diatom blooms. We identified a β-mannan polysaccharide utilization locus (PUL) in the genome of the marine flavobacterium Muricauda sp. MAR_2010_75. Proteomics showed β-mannan induced translation of 22 proteins encoded within the PUL. Biochemical and structural analyses deduced the enzymatic cascade for β-mannan utilization. A conserved GH26 β-mannanase with endo-activity depolymerized the β-mannan. Consistent with the biochemistry, X-ray crystallography showed the typical TIM-barrel fold of related enzymes found in terrestrial β-mannan degraders. Structural and biochemical analyses of a second GH26 allowed the prediction of an exo-activity on shorter manno-gluco oligosaccharides. Further analysis demonstrated exo-α-1,6-galactosidase- and endo-β-1,4-glucanase activity of the PUL-encoded GH27 and GH5_26, respectively, indicating the target substrate is a galactoglucomannan. Epitope deletion assays with mannanases as analytic tools indicate the presence of β-mannan in the diatoms Coscinodiscus wailesii and Chaetoceros affinis. Mannanases from the PUL were active on diatom β-mannan and polysaccharide extracts sampled during a microalgal bloom at the North Sea. Together these results demonstrate that marine microorganisms use a conserved enzymatic cascade to degrade β-mannans of marine and terrestrial origin and that this metabolic pathway plays a role in marine carbon cycling.
The absorption of drugs with narrow absorption windows in the upper small intestine can be improved with a mucoadhesive drug delivery system such as enteric films. To predict the mucoadhesive behaviour in vivo, suitable in vitro or ex vivo methods can be performed. In this study, the influence of tissue storage and sampling site on the mucoadhesion of polyvinyl alcohol film to human small intestinal mucosa was investigated. Tissue from twelve human subjects was used to determine adhesion using a tensile strength method. Thawing of tissue frozen at −20 °C resulted in a significantly higher work of adhesion (p = 0.0005) when a low contact force was applied for one minute, whereas the maximum detachment force was not affected. When the contact force and time were increased, no differences were found for thawed tissue compared to fresh tissue. No change in adhesion was observed depending on the sampling location. Initial results from a comparison of adhesion to porcine and human mucosa suggest that the tissues are equivalent.
Purpose
Mixing with liquids or soft foods is a common procedure to improve acceptability of oral medicines in children but may affect drug stability and the in vivo performance of the administered drug product. The aim of the present study was to obtain an overview of the variability of critical attributes of commonly used vehicles and to identify which vehicle characteristics need to be considered when developing in vitro methods for evaluating product quality.
Methods
One product of each vehicle listed in the FDA draft guidance “Use of Liquids and/or Soft Foods as Vehicles for Drug Administration” was analyzed with regard to composition, calorific content and physicochemical properties.
Results
The studied vehicles show wide variability, both in composition and physicochemical properties. No correlation was observed between vehicle composition and physicochemical properties. Comparison of results of the present study with previously published data also provided variability in physicochemical properties within individual vehicle types.
Conclusions
To identify acceptable (qualified) vehicles for global drug product labeling, it is important that the vehicles selected for in vitro compatibility screening reflect the variability in composition and essential physicochemical properties of the vehicles recommended on the product label, rather than relying on results obtained with a single vehicle of each type. Future activities will focus on the development of standardized dosing vehicles that can represent key vehicle characteristics in all their variability to ensure reliable risk assessment.
Humans consume snail flesh as part of their diet. To assess its nutritional value and toxicity, chemical analyses were conducted to confirm the presence of protein, total and reduced carbohydrates, fat, fatty acid composition and mineral components. Furthermore, an acute toxicity study was carried out to determine the safety of Helix aspersa Müller snail flesh. H. aspersa Müller snail flesh exhibits a high nutritional content, a good ω3/ω6 ratio and higher levels of unsaturated fatty acids. Various minerals have been found in the flesh of H. aspersa Müller. Around 76.91 kcal, or 3.84% of the energy of a daily meal of 2000 kcal, are present in 100 g of this flesh. The evaluation of the antioxidant capacity indicated that the flesh’s extracts contained a large quantity of antioxidant biomolecules. Administration of the aqueous extract of H. aspersa Müller flesh didn’t cause death in laboratory rats, indicating that the lethal dose 50 is greater than 2000 mg·kg−1 body weight. The consumption of the flesh of H. aspersa Müller is highly recommended for human consumption due to its high concentration of nutrients and essential elements, as well as unsaturated fats, and due to its safety.
The microbiome of the colon is characterized by its great diversity. This varies not only intra- but also interindividually and is influenced by endogenous and exogenous factors, such as dietary and lifestyle factors. The aim of this work was to investigate the extent to which the degradation of the drug sulfasalazine is influenced by different microbiota. Therefore, the in vitro model MimiCol3 was used, which represents the physiological conditions of the ascending colon. In addition to a representative physiological volume, the pH value, redox potential and an anaerobic atmosphere are important to provide the bacteria with the best possible growth conditions. Stool samples were taken from three healthy subjects, comparing omnivorous, vegetarian and meat-rich diets, and cultured for 24 h. However, the nutrient medium used for cultivation led to the alignment of the bacterial composition of the microbiota. The previously observed differences between the diets could not be maintained. Nevertheless, the similar degradation of sulfasalazine was observed in all microbiota studied in MimiCol3. This makes MimiCol3 a suitable in vitro model for metabolism studies in the gut microbiome.
Development of Test Programs for the Biorelevant Characterization of Esophageal-Applied Dosage Forms
(2023)
In the local treatment of the esophageal mucosa, the retention time of the different dosage forms, such as tablets, films or liquids, is of high relevance for the effective treatment of diseases. Unfortunately, there are only few in vitro models describing the esophageal route of administration. To predict the behaviour of an esophageal-applied dosage form, it is necessary to simulate the site of application in a biorelevant way. The aim of this work was to develop two test setups for an esophageal peristalsis model which was described in a previous study. Different parameters such as flow rate, peristalsis, angle of inclination or mucous membrane were varied or introduced into the model. A stimulated and unstimulated modus were developed and tested with two different dosage forms. The time until the dosage form was cleared from the in vitro model was shorter with the stimulated than with the unstimulated modus. Also, esophageal-applied films had a prolonged transit time compared to a viscous syrup. The modification of the simulated esophageal surface made it possible to estimate the retention time of the dosage forms. It could be demonstrated that the residence time of a dosage form depends on different parameters affecting each other.
Despite recent advances in the treatment of non-small cell lung cancer (NSCLC), acquired drug resistance to targeted therapy remains a major obstacle. Epithelial-mesenchymal transition (EMT) has been identified as a key resistance mechanism in NSCLC. Here, we investigated the mechanistic role of key EMT-regulating small non-coding microRNAs (miRNAs) in sublines of the NSCLC cell line HCC4006 adapted to afatinib, erlotinib, gefitinib, or osimertinib. The most differentially expressed miRNAs derived from extracellular vesicles were associated with EMT, and their predicted target ZEB1 was significantly overexpressed in all resistant cell lines. Transfection of a miR-205-5p mimic partially reversed EMT by inhibiting ZEB1, restoring CDH1 expression, and inhibiting migration in erlotinib-resistant cells. Gene expression of EMT-markers, transcription factors, and miRNAs were correlated during stepwise osimertinib adaptation of HCC4006 cells. Temporally relieving cells of osimertinib reversed transition trends, suggesting that the implementation of treatment pauses could provide prolonged benefits for patients. Our results provide new insights into the contribution of miRNAs to drug-resistant NSCLC harboring EGFR-activating mutations and highlight their role as potential biomarkers and therapeutic targets.
Background and Objectives: Alzheimer’s disease (AD) stands as a pervasive neurodegenerative ailment of global concern, necessitating a relentless pursuit of remedies. This study aims to furnish a comprehensive exposition, delving into the intricate mechanistic actions of medicinal herbs and phytochemicals. Furthermore, we assess the potential of these compounds in inhibiting human acetylcholinesterase through molecular docking, presenting encouraging avenues for AD therapeutics. Materials and Methods: Our approach entailed a systematic exploration of phytochemicals like curcumin, gedunin, quercetin, resveratrol, nobiletin, fisetin, and berberine, targeting their capability as human acetylcholinesterase (AChE) inhibitors, leveraging the PubChem database. Diverse bioinformatics techniques were harnessed to scrutinize molecular docking, ADMET (absorption, distribution, metabolism, excretion, and toxicity), and adherence to Lipinski’s rule of five. Results: Results notably underscored the substantial binding affinities of all ligands with specific amino acid residues within AChE. Remarkably, gedunin exhibited a superior binding affinity (−8.7 kcal/mol) compared to the reference standard. Conclusions: These outcomes accentuate the potential of these seven compounds as viable candidates for oral medication in AD treatment. Notably, both resveratrol and berberine demonstrated the capacity to traverse the blood-brain barrier (BBB), signaling their aptitude for central nervous system targeting. Consequently, these seven molecules are considered orally druggable, potentially surpassing the efficacy of the conventional drug, donepezil, in managing neurodegenerative disorders.
Synthesis of Quercetin-Loaded Silver Nanoparticles and Assessing Their Anti-Bacterial Potential
(2023)
The study delves into the multifaceted potential of quercetin (Qu), a phytoconstituent found in various fruits, vegetables, and medicinal plants, in combination with silver nanoparticles (AgNPs). The research explores the synthesis and characterization of AgNPs loaded with Qu and investigates their pharmaceutical applications, particularly focusing on antibacterial properties. The study meticulously evaluates Qu’s identity, and physicochemical properties, reaffirming its suitability for pharmaceutical use. The development of Qu-loaded AgNPs demonstrates their high drug entrapment efficiency, ideal particle characteristics, and controlled drug release kinetics, suggesting enhanced therapeutic efficacy and reduced side effects. Furthermore, the research examines the antibacterial activity of Qu in different solvents, revealing distinct outcomes. Qu, both in methanol and water formulations, exhibits antibacterial activity against Escherichia coli, with the methanol formulation displaying a slightly stronger efficacy. In conclusion, this study successfully synthesizes AgNPs loaded with Qu and highlights their potential as a potent antibacterial formulation. The findings underscore the influence of solvent choice on Qu’s antibacterial properties and pave the way for further research and development in drug delivery systems and antimicrobial agents. This innovative approach holds promise for addressing microbial resistance and advancing pharmaceutical formulations for improved therapeutic outcomes.