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Phylogeny of the Koi herpesvirus and development of a vaccine against the Koi herpesvirus disease
(2019)
The aim of this presented dissertation was a stable, live attenuated and protective KHV usable as vaccine. Moreover this vaccine should by cost effective and easy to apply. Differentiation of infected and vaccinated animals was preferred by genetic and / or serological means. After achieving an attenuated virus, whole genome sequencing should be done to examine the genetic of the vaccine as one feature of biosafety. Besides biosafety additional knowledge on the virulence of Alloherpesviruses, especially of KHV was anticipated. Additionally the diagnostics of KHV and KHVD should be improved to increase reliability and to gain more insights into the relationship of different KHVs and hopefully to detect the source of an outbreak.
Abstract
Over the last years, there has been an enormous increase in the knowledge on koi herpesvirus (KHV), koi herpesvirus disease (KHVD), pathogenesis and virus variants. Different KHV lineages have clearly been identified, possible genomic changes during replication in different cell cultures at different temperatures but also in several hosts have been identified, a persistent stage of infection has been specified and it has been shown that infection with KHV is not host specific at all, but KHVD is. Additionally, it has been shown that it is possible to combat KHVD by immunization with inactivated and attenuated live vaccines using different delivery systems but also to benefit from alternative treatments with e.g. exopolysaccharids obtained from Arthrospira platensis.