Refine
Year of publication
- 2012 (59) (remove)
Document Type
- Doctoral Thesis (38)
- Article (21)
Language
- English (59) (remove)
Has Fulltext
- yes (59)
Is part of the Bibliography
- no (59)
Keywords
- - (20)
- Proteomanalyse (3)
- Atmosphärendruckplasma (2)
- Communication abilities (2)
- Gene expression (2)
- Kaltes Plasma (2)
- Phylogenie (2)
- Streptococcus pneumoniae (2)
- oxidative stress (2)
- 2-Phenoxyethanol (1)
- ASPS (1)
- AUDIT (1)
- AUDIT-C (1)
- Abregung (1)
- Adhäsine (1)
- Aeromonas salmonicida (1)
- Agoraphobia (1)
- Agoraphobie (1)
- Akupunktur (1)
- Alcohol abuse (1)
- Alcohol dependence (1)
- Altern (1)
- Aluminium (1)
- Aminoacylierung (1)
- Amperometric detection; EstraMonitor (1)
- Amperometrische Detektion; EstraMonitor (1)
- Angewandte Linguistik (1)
- Angst (1)
- Anion (1)
- Antibiotics (1)
- Antibody (1)
- Antioxidants (1)
- Antisepsis (1)
- Antiseptic (1)
- Antiseptic efficacy (1)
- AnxA1 (1)
- Aortic compliance (1)
- Apolipoprotein E knockout mice (1)
- Applied linguistics (1)
- Arrowworms (1)
- Aspiration (1)
- At-risk drinking (1)
- Atemwegsobstruktion (1)
- Attachmentverlust (1)
- Auftrittsgröße (1)
- Autism spectrum disorder (1)
- Autophagie (1)
- Autophagy (1)
- Baboon (1)
- Bacillus (1)
- Bacillus subtilis (1)
- Bacterial vaginosis (1)
- Baeyer-Villiger monooxygenase (1)
- Baeyer-Villiger-Oxidation (1)
- Bakterielle Infektion (1)
- Bauchfellentzündung (1)
- Beam (1)
- Biokatalyse (1)
- Biosensor (1)
- Birds (1)
- Bleeding (1)
- Borderline personality disorder (1)
- Brain evolution (1)
- Burkholderia pseudomallei (1)
- C. elegans (1)
- CRAFFT (1)
- Caenorhabditis elegans (1)
- Campher (1)
- Caries activity (1)
- Caries risk (1)
- Chaetognatha (1)
- Chimpanzee (1)
- Chromosome 7q31-q36 (1)
- Clusterion (1)
- Clusterphysik (1)
- Cognitive-behavioral therapy (1)
- Comorbidity (1)
- Cortex (1)
- Cytometrie (1)
- DBD (1)
- DDR (1)
- DNA Triplex (1)
- DNA triplex (1)
- DNA-Wirkstoff-Interaktion (1)
- DNA-drug interaction (1)
- DNS (1)
- Darbellay-Vajda Partitionsregel (1)
- De- and remineralisation (1)
- De-Excitation (1)
- Dekontamination (1)
- Depression (1)
- Diagnostics (1)
- Dielectric Barrier Discharge (1)
- Dielektrische Entladung (1)
- Dilatative Kardiomyopathie (1)
- Dilated Cardiomyopathy (1)
- Duennschichten (1)
- EEG (1)
- Elastase inhibitor (1)
- Elastase inhibitoren (1)
- Elektronenbad (1)
- Elektrospray-Ionisation (1)
- Entzündung (1)
- Enzymkatalyse (1)
- Epidemiologie (1)
- Europa (1)
- Europe (1)
- Exposure (1)
- FT-ICR-Spektroskopie (1)
- FT-IR-Spektroskopie (1)
- FTIR spectroscopy (1)
- FTIR-Spektrometrie (1)
- Familial transmission pathways (1)
- Flavine (1)
- Flow Cytometry (1)
- Flugzeitspektrometrie (1)
- Foraminiferen (1)
- Friedland clay (1)
- Friedland tons (1)
- Funktionalisierung <Chemie> (1)
- Furcht (1)
- Fusionsplasma (1)
- Ganzkörper-CT (1)
- Genital tract infection (1)
- Glaucoma (1)
- Glomus irregulare (1)
- Glutathion (1)
- Green-Funktion (1)
- Grönland (1)
- HLW- Endlager (1)
- HLW- repository (1)
- Hanta-Virus (1)
- Hantavirus (1)
- Heart rate reduction (1)
- Hearts (1)
- Hefeartige Pilze (1)
- Heißes Plasma (1)
- Herzen (1)
- Holozän (1)
- Host range (1)
- Human papilloma virus (1)
- Hydrogen sulphide (1)
- Immuncytochemie (1)
- Immune system (1)
- Impfstoff (1)
- Imprinting (1)
- Indolochinolin (1)
- Infektion (1)
- Informationsabhängigkeit (1)
- Infrarotspektroskopie (1)
- Ionenfalle (1)
- Ivabradine (1)
- Jet ventilation (1)
- Kalziumsignale (1)
- Kinderheilkunde (1)
- Kongestive Herzmuskelkrankheit (1)
- LC-MS (1)
- Language evolution (1)
- Level-Set-Methode (1)
- Litauen (1)
- Lithuania (1)
- Low Temperature Plasma (1)
- Lungenfunktion (1)
- Lungenvolumen (1)
- MALDI-MS (1)
- MIR-Spektroskopie (1)
- MX80-bentonit (1)
- MX80-bentonite (1)
- Marmoset (1)
- Mass Specrtometry (1)
- Massenspektrometrie (1)
- Maßanalyse (1)
- Mehrsprachigkeit (1)
- Melioidosis (1)
- Metabolom (1)
- Metallcluster (1)
- Mice (1)
- Minkowski-Metrik (1)
- Mitteleuropa (1)
- Moldawien (1)
- Moldova (1)
- Monoklonaler Antikörper (1)
- Monooxygenasen (1)
- Monte-Carlo-Simulation (1)
- Morbidität (1)
- Mortalität (1)
- Mosaicism (1)
- Mother-child disagreement (1)
- Mäuse (1)
- NADPH oxidase (1)
- Neuroendocrine tumors (1)
- Neutralisation (1)
- Neutralization (1)
- Nichtgleichgewicht (1)
- Normal phenotype (1)
- Oberflächenstöße (1)
- Observational study (1)
- Octenidine dihydrochloride (1)
- Ocular perfusion pressure (1)
- Ocular tonometry (1)
- Ostdeutschland (1)
- PCV7 (1)
- POSIT (1)
- Paläoozeanographie (1)
- Pancreatitis (1)
- Panic disorder (1)
- Panikstörung (1)
- Paniksyndrom (1)
- Pankreatitis (1)
- Parenting (1)
- Parodontitis (1)
- Particle in Cell Simulation (1)
- PavB (1)
- Penning trap (1)
- Penningfalle (1)
- Peritonitis (1)
- Pfeilwürmer (1)
- Phylogenetische Systematik (1)
- Phylogeny (1)
- Pili (1)
- Pilus Islet-1 (1)
- Pilus Islet-2 (1)
- Pituitary (1)
- Plasma (1)
- Plasma Instability (1)
- Plasma dynamics (1)
- Plasma treatment in vivo (1)
- Plasma-Wand-Wechselwirkung (1)
- Plasmachemie (1)
- Plasmadynamik (1)
- Plasmainstabilität (1)
- Plasmaphysik (1)
- Plasmarandschicht (1)
- Plasmaschwingung (1)
- Plasmaspektroskopie (1)
- Pneumokokken (1)
- Polihexanide (1)
- Polyanion (1)
- Polyhexamethylene biguanide (1)
- Polymere (1)
- Polytrauma (1)
- Postoperative immune suppression (1)
- Primary care (1)
- Primate evolution (1)
- Promoter methylation (1)
- Proteom (1)
- Protestantismus (1)
- Pseudomonas putida (1)
- PspC (1)
- PspC-hpIgR-vermittelten Endozytose (1)
- PsrP (1)
- Quantitative light-induced fluorescence (1)
- Quasi-Pseudo-Metrik (1)
- RNS (1)
- Rainbow trout (1)
- Randomized controlled trial (1)
- Regenbogenforelle (1)
- Ribozym (1)
- Schadstoffabbau (1)
- Schmerz (1)
- Screening, adolescents (1)
- Secondary Electrons (1)
- Segmentierung (1)
- Sekundärelektronen (1)
- Selective breeding (1)
- Sepsis (1)
- SigB (1)
- Skin barrier (1)
- Smoking cessation (1)
- Social brain (1)
- Somatostatin (1)
- Somatostatin receptor (1)
- Sondierungstiefe (1)
- Spektroskopie (1)
- Spillover Infections (1)
- Spillover-Infektionen (1)
- Sporulation (1)
- Sprachlandschaften (1)
- Staphylococcus aureus (1)
- Stoffwandlung (1)
- Surface Collisions (1)
- Systematik (1)
- T cell receptor beta locus (1)
- Telemedicine (1)
- Tetrasomy 9p (1)
- Theologie (1)
- Thermodynamik (1)
- Thin films (1)
- Titan Tholins (1)
- Titan-Tholine (1)
- Ton-Eisen interaktion (1)
- Trabectedin (1)
- Tracheal surgery (1)
- Transporttheorie (1)
- Trauma (1)
- Turbulenz (1)
- Unabhängigkeitanalyse (1)
- Varenicline (1)
- Variationsrechnung (1)
- Verhaltenstest (1)
- Vietnam (1)
- Virulenz (1)
- Vögel (1)
- Wasserstoffperoxid (1)
- Wirtsspektrum (1)
- Zahnmedizin (1)
- Zahnzahl (1)
- Zellkultur (1)
- acupuncture (1)
- aging (1)
- agoraphobia (1)
- airflow limitation (1)
- airway epithelial cells (1)
- angiotensin (1)
- appearance size (1)
- arbuscular mycorrhizal fungi (1)
- atmospheric pressure plasma (1)
- atrial fibrillation (1)
- behavioral avoidance test (1)
- biological decontamination (1)
- children (1)
- clay-iron interaction (1)
- climate change (1)
- clinical attachment loss (1)
- culture based method (1)
- defensive Reaktivität (1)
- defensive reactivity (1)
- dendrochronology (1)
- dentistry (1)
- diketocamphane monooxygenase (1)
- electron bath (1)
- extension of glacier records (1)
- extravasation (1)
- fear (1)
- flavin reductase (1)
- fumarate reductase (1)
- general stress response (1)
- generelle Stressantwort (1)
- genome size (1)
- glaciology (1)
- gyrokinetic (1)
- gyrokinetisch (1)
- hydrogen peroxide (1)
- hypothermia (1)
- indoloquinoline (1)
- konsistente Schätzung (1)
- linguistic landscapes (1)
- lung function (1)
- lung volume (1)
- microinstabilities (1)
- microinstabilitäten (1)
- microvascular flow (1)
- morbidity (1)
- mortality (1)
- multilingualism (1)
- natural analougs (1)
- natürliches Analogon (1)
- neoclassic (1)
- neoklassisch (1)
- neutrophil (1)
- non-thermal plasma (1)
- pain (1)
- panic disorder (1)
- periodontal disease (1)
- phylogeny (1)
- plasma (1)
- plasma chemistry (1)
- plasma diagnostics (1)
- pollution control (1)
- polyanion (1)
- population-based study (1)
- populationsbasierte Studie (1)
- proteomics (1)
- qPCR (1)
- reactive oxygen species (ROS) (1)
- regulatorisches Netzwerk (1)
- regulatory network (1)
- species conversion (1)
- specific dissolution potential (1)
- spezifisches Auflösungspotential (1)
- sporulation (1)
- stellarator (1)
- stichprobenabhängige Partitionsregel (1)
- stroke (1)
- surface modification (1)
- whole body multislice CT (1)
- Östrogen-Rezeptor-Modulator (1)
- Östrogene (1)
Institute
- Institut für Physik (7)
- Institut für Mikrobiologie - Abteilung für Genetik & Biochemie (5)
- Abteilung für Mikrobiologie und Molekularbiologie (4)
- Institut für Biochemie (4)
- Institut für Mathematik und Informatik (3)
- Institut für Geographie und Geologie (2)
- Institut für Hygiene und Umweltmedizin (2)
- Institut für Med. Biochemie u. Molekularbiologie (2)
- Institut für Pharmazie (2)
- Institut für Psychologie (2)
Publisher
ZusammenfassungDer Aufsatz bietet den ersten konsistenten Überblick über den Wandel der politischen Positionen der protestantischen Theologie in der DDR. Mit Hilfe von Anregungen aus der Cambridge School der Ideengeschichte geht der Text der Frage nach, inwieweit die ostdeutsche evangelische Theologie Resistenzpotential gegenüber dem politischen Anpassungsdruck des SED-Regimes aufzubringen vermochte. Dabei widersprechen die Autoren der in der Forschung verbreiteten Auffassung, die Protestanten hätten die Theologie in obrigkeitstreuer Tradition einmal mehr den neuen Verhältnissen angepasst. Vielmehr lässt sich ein deutlicher Bruch nach 1945 erkennen, eine jahrelang anhaltende Kritik an der atheistischen Regierung und ein theologisches Ringen um ein angemessenes Obrigkeitsverständnis. Erst äußere Anlässe brachten die Kirchen dazu, ihre fundamentalkritische Theologie Zug um Zug aufzugeben. Dazu gehört die Zementierung der deutschen Teilung, die den Rückhalt der ostdeutschen Kirchen in der gesamtdeutschen EKD schwächte, oder auch die Ungleichheit in der Verteilung der Machtmittel, die die Kirchen an den Staat auslieferten. Neben diesen strukturellen Gründen benennen die Autoren ideelle Motive wie die Kritik an der Institution EKD, durch die sich die jüngeren Theologen von der älteren Generation ablösen wollten. Einflussreich waren auch internationale ökumenische Diskurse, die seit den siebziger Jahren den Kapitalismus zunehmend kritisch und den Sozialismus entsprechend positiv einordneten. Obwohl die wenigen verbliebenen Christen sich immer wieder unangepasst verhielten, ließ sich die Theologie insgesamt mehr und mehr zur Rechtfertigung des Anpassungsweges einspannen. Nicht sie bestimmte die politische Haltung. Vielmehr gaben äußere Faktoren die theologischen Positionsbestimmungen der Kirche vor.
In order to identify possible experimental signatures of the superfluid to Mott-insulator quantum phase transition we calculate the charge structure factor S(k, ω) for the one-dimensional Bose-Hubbard model using the dynamical density-matrix renormalisation group (DDMRG) technique. Particularly we analyse the behaviour of S(k, ω) by varying – at zero temperature–the Coulomb interaction strength within the first Mott lobe. For strong interactions, in the Mott-insulator phase, we demonstrate that the DDMRG results are well reproduced by a strong-coupling expansion, just as the quasi-particle dispersion. In the super-fluid phase we determine the linear excitation spectrum near k = 0. In one dimension, the amplitude mode is absent which mean-field theory suggests for higher dimensions.
Abstract
We present experiments on the luminescence of excitons confined in a potential trap at milli-Kelvin bath temperatures under continuous-wave (cw) excitation. They reveal several distinct features like a kink in the dependence of the total integrated luminescence intensity on excitation laser power and a bimodal distribution of the spatially resolved luminescence. Furthermore, we discuss the present state of the theoretical description of Bose–Einstein condensation of excitons with respect to signatures of a condensate in the luminescence. The comparison of the experimental data with theoretical results with respect to the spatially resolved as well as the integrated luminescence intensity shows the necessity of taking into account a Bose–Einstein condensed excitonic phase in order to understand the behaviour of the trapped excitons.
Abstract
In the 21st century, most of the world’s glaciers are expected to retreat due to further global warming. The range of this predicted retreat varies widely as a result of uncertainties in climate and glacier models. To calibrate and validate glacier models, past records of glacier mass balance are necessary, which often only span several decades. Long-term reconstructions of glacier mass balance could increase the precision of glacier models by providing the required calibration data. Here we show the possibility of applying shrub growth increments as an on-site proxy for glacier summer mass balance, exemplified by Salix shrubs in Finse, Norway. We further discuss the challenges which this method needs to meet and address the high potential of shrub growth increments for reconstructing glacier summer mass balance in remote areas.
Patients with atrial fibrillation (AF) often present with typical angina pectoris and mildly elevated levels of cardiac troponin (non-ST-segment elevation myocardial infarction) during an acute episode of AF. However, in a large proportion of these patients, significant coronary artery disease is excluded by coronary angiography, which suggests that AF itself influences myocardial blood flow. The present review summarizes the effect of AF on the occurrence of ventricular oxidative stress, redox-sensitive signaling pathways and gene expression, and microcirculatory flow abnormalities in the left ventricle.
Heart Rate Reduction by Ivabradine Improves Aortic Compliance in Apolipoprotein E-Deficient Mice
(2012)
Background: Impaired vascular compliance is associated with cardiovascular mortality. The effects of heart rate on vascular compliance are unclear. Therefore, we characterized effects of heart rate reduction (HRR) by I(f) current inhibition on aortic compliance and underlying molecular mechanisms in apolipoprotein E-deficient (ApoE<sup>–</sup>/<sup>–</sup>) mice. Methods: ApoE<sup>–</sup>/<sup>–</sup> mice fed a high-cholesterol diet and wild-type (WT) mice were treated with ivabradine (20 mg/kg/d) or vehicle for 6 weeks. Compliance of the ascending aorta was evaluated by MRI. Results: Ivabradine reduced heart rate by 113 ± 31 bpm (∼19%) in WT mice and by 133 ± 6 bpm (∼23%) in ApoE<sup>–</sup>/<sup>–</sup> mice. Compared to WT controls, ApoE<sup>–</sup>/<sup>–</sup> mice exhibited reduced distensibility and circumferential strain. HRR by ivabradine increased distensibility and circumferential strain in ApoE<sup>–</sup>/<sup>–</sup> mice but did not affect both parameters in WT mice. Ivabradine reduced aortic protein and mRNA expression of the angiotensin II type 1 (AT1) receptor and reduced rac1-GTPase activity in ApoE<sup>–</sup>/<sup>–</sup> mice. Moreover, membrane translocation of p47<sup>phox</sup> was inhibited. In ApoE<sup>–</sup>/<sup>–</sup> mice, HRR induced anti-inflammatory effects by reduction of aortic mRNA expression of IL-6, TNF-alpha and TGF-beta. Conclusion: HRR by ivabradine improves vascular compliance in ApoE<sup>–</sup>/<sup>–</sup> mice. Contributing mechanisms include downregulation of the AT1 receptor, attenuation of oxidative stress and modulation of inflammatory cytokine expression.
The human brain is distinguished by its remarkable size, high energy consumption, and cognitive abilities compared to all other mammals and non-human primates. However, little is known about what has accelerated brain evolution in the human lineage. One possible explanation is that the appearance of advanced communication skills and language has been a driving force of human brain development. The phenotypic adaptations in brain structure and function which occurred on the way to modern humans may be associated with specific molecular signatures in today’s human genome and/or transcriptome. Genes that have been linked to language, reading, and/or autism spectrum disorders are prime candidates when searching for genes for human-specific communication abilities. The database and genome-wide expression analyses we present here revealed a clustering of such communication-associated genes (COAG) on human chromosomes X and 7, in particular chromosome 7q31-q36. Compared to the rest of the genome, we found a high number of COAG to be differentially expressed in the cortices of humans and non-human primates (chimpanzee, baboon, and/or marmoset). The role of X-linked genes for the development of human-specific cognitive abilities is well known. We now propose that chromosome 7q31-q36 also represents a hot spot for the evolution of human-specific communication abilities. Selective pressure on the T cell receptor beta locus on chromosome 7q34, which plays a pivotal role in the immune system, could have led to rapid dissemination of positive gene variants in hitchhiking COAG.
The autism susceptibility locus on human chromosome 7q32 contains the maternally imprinted MEST and the non-imprinted COPG2 and TSGA14 genes. Autism is a disorder of the ‘social brain’ that has been proposed to be due to an overbalance of paternally expressed genes. To study regulation of the 7q32 locus during anthropoid primate evolution, we analyzed the methylation and expression patterns of MEST, COPG2, and TSGA14 in human, chimpanzee, Old World monkey (baboon and rhesus macaque), and New World monkey (marmoset) cortices. In all human and anthropoid primate cortices, the MEST promoter was hemimethylated, as expected for a differentially methylated imprinting control region, whereas the COPG2 and TSGA14 promoters were completely demethylated, typical for transcriptionally active non-imprinted genes. The MEST gene also showed comparable mRNA expression levels in all analyzed species. In contrast, COPG2 expression was downregulated in the human cortex compared to chimpanzee, Old and New World monkeys. TSGA14 either showed no differential regulation in the human brain compared to chimpanzee and marmoset or a slight upregulation compared to baboon. The human-specific downregulation supports a role for COPG2 in the development of a ‘social brain’. Promoter methylation patterns appear to be more stable during evolution than gene expression patterns, suggesting that other mechanisms may be more important for inter-primate differences in gene expression.
Tetrasomy 9p is a rare chromosomal syndrome and about 30% of known cases exhibit mosaicism. Approximately 50 of the reported cases with tetrasomy 9p mosaicism show a characteristic facial appearance, growth failure, and developmental delay. However, 3 patients with mosaicism for isochromosome 9p and a normal phenotype have also been reported. We report 2 additional cases of clinically normal young females with tetrasomy 9p mosaicism, one of whom also exhibited X chromosome aneuploidy mosaicism leading to an overall of 6 different cell lines. STR analysis performed on this complex mosaic case indicated that the extra isochromosome was of maternal origin while the X chromosome aneuploidy was of paternal origin, indicating a postzygotic event.
The aim of this study was to analyse the predictive power of several clinical baseline parameters and the de-/remineralisation properties of in vivo etched sites measured with quantitative light-induced fluorescence (QLF) for subsequent 2-year caries increment. At baseline, in 44 children (8.23 ± 1.5 years) two areas (diameter 2 mm) of the buccal surface of a primary posterior tooth were etched with 36% phosphoric acid gel for 1 and 4 min, respectively. The etched sites were analysed immediately after etching (ΔQ1) and 24 h (ΔQ2) later by QLF. Additionally, caries status (deft/DMFT and initial caries), approximal plaque, bleeding on probing, and the patient’s current use of fluorides were recorded. In the 2-year follow-up, 29 children were re-assessed. After clinical examination, the caries increment was calculated (ΔDMFT) and correlated with the baseline clinical variables and the QLF readings. Results showed a significant positive correlation between ΔQ<sub>1 min</sub> and the ΔDMFT (r = 0.44, p = 0.02). The ΔDMFT was significantly correlated with the baseline deft (r = 0.56, p = 0.002), cavitated active caries lesions (r = 0.52, p = 0.003), and filled teeth (r = 0.53, p = 0.003). In a regression analysis the use of fluoridated salt (SC = –0.10) and fluoride gel (SC = –0.14) were negatively associated with ΔDMFT. In conclusion, these findings suggest that the demineralisation properties of the etched sites and the outcome of the 24-hour measurements with QLF are significantly associated with caries increment. Previous caries experience strongly correlated with caries increment in this group of children.