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Limited Add-On Effects of Unilateral and Bilateral Transcranial Direct Current Stimulation on Visuo-Motor Grip Force Tracking Task Training Outcome in Chronic Stroke. A Randomized Controlled Trial
- Background: This randomized controlled trial investigated if uni- and bihemispheric transcranial direct current stimulation (tDCS) of the motor cortex can enhance the effects of visuo-motor grip force tracking task training and transfer to clinical assessments of upper extremity motor function. Methods: In a randomized, double-blind, sham-controlled trial, 40 chronic stroke patients underwent 5 days of visuo-motor grip force tracking task training of the paretic hand with either unilateral or bilateral (N = 15/group) or placebo tDCS (N = 10). Immediate and long-term (3 months) effects on training outcome and motor recovery (Upper Extremity Fugl-Meyer, UE-FM, Wolf Motor Function Test, and WMFT) were investigated. Results: Trained task performance significantly improved independently of tDCS in a curvilinear fashion. In the anodal stimulation group UE-FM scores were higher than in the sham group at day 5 (adjusted mean difference: 2.6, 95%CI: 0.6–4.5, p = 0.010) and at 3 months follow up (adjusted mean difference: 2.8, 95%CI: 0.8–4.7, p = 0.006). Neither training alone, nor the combination of training and tDCS improved WMFT performance. Conclusions: Visuo-motor grip force tracking task training can facilitate recovery of upper extremity function. Only minimal add-on effects of anodal but not dual tDCS were observed. Clinical Trial Registration: https://clinicaltrials.gov/ct2/results?recrs=&cond=&term=NCT01969097&cntry=&state=&city=&dist=, identifier: NCT01969097, retrospectively registered on 25/10/2013.
Author: | Benedikt Taud, Robert Lindenberg, Robert Darkow, Jasmin Wevers, Dorothee Höfflin, Ulrike GrittnerORCiD, Marcus Meinzer, Agnes FlöelORCiD |
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URN: | urn:nbn:de:gbv:9-opus-57612 |
DOI: | https://doi.org/10.3389/fneur.2021.736075 |
ISSN: | 1664-2295 |
Parent Title (English): | Frontiers in Neurology |
Publisher: | Frontiers Media S.A. |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2020/05/22 |
Date of first Publication: | 2021/11/11 |
Release Date: | 2022/06/10 |
Tag: | chronic stroke; hand function; motor function; motor rehabilitation; tDCS |
GND Keyword: | - |
Volume: | 12 |
Article Number: | 736075 |
Page Number: | 10 |
Faculties: | Universitätsmedizin / Klinik und Poliklinik für Neurochirurgie |
Licence (German): | Creative Commons - Namensnennung |