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Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures
- Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the p-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of Staphylococcus species, including multidrug-resistant strains.
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| Author: | Annett Mikolasch, Veronika Hahn |
|---|---|
| URN: | urn:nbn:de:gbv:9-opus-57218 |
| DOI: | https://doi.org/10.3390/microorganisms9112199 |
| ISSN: | 2076-2607 |
| Parent Title (English): | Microorganisms |
| Publisher: | MDPI |
| Editor: | Annett Mikolasch, Mariam Gaid |
| Document Type: | Article |
| Language: | English |
| Date of first Publication: | 2021/10/21 |
| Release Date: | 2021/11/08 |
| Tag: | antibacterial activity; antimicrobial resistance (AMR); biotransformation; laccase; methicillin-resistant; multidrug resistance (MDR); sulfonamide antibiotics; β-lactam antibiotics |
| GND Keyword: | - |
| Volume: | 9 |
| Issue: | 11 |