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The Role of Vascular Risk Factors in Post-Stroke Delirium: A Systematic Review and Meta-Analysis
- Vascular risk factors may predispose to post-stroke delirium (PSD). A systematic review and meta-analysis were performed by searching PubMed, Web of Science, and Scopus. The primary outcome was the prevalence of vascular risk factors in PSD vs. non-PSD patients. Odds ratios (ORs) with 95% confidence intervals (CIs) and mean differences (MDs) with 95% CIs were calculated for categorical and continuous variables, respectively. Fixed effects or random effects models were used in case of low- or high-statistical heterogeneity, respectively. We found an increased prevalence of atrial fibrillation (OR = 1.74, p = 0.0004), prior stroke (OR = 1.48, p < 0.00001), coronary artery disease (OR = 1.48, p < 0.00001), heart failure (OR = 2.01, p < 0.0001), and peripheral vascular disease (OR = 2.03, p < 0.00001) in patients with vs. without PSD. PSD patients were older (MD = 5.27 y, p < 0.00001) compared with their non-PSD counterparts. Advanced age, atrial fibrillation, prior stroke, coronary artery disease, heart failure, and peripheral vascular disease appeared to be significantly associated with PSD.
Author: | Vasileios Siokas, Robert FleischmannORCiD, Katharina Feil, Ioannis Liampas, Markus C. Kowarik, Yang Bai, Maria-Ioanna Stefanou, Sven Poli, Ulf Ziemann, Efthimios Dardiotis, Annerose Mengel |
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URN: | urn:nbn:de:gbv:9-opus-76021 |
DOI: | https://doi.org/10.3390/jcm11195835 |
ISSN: | 2077-0383 |
Parent Title (English): | Journal of Clinical Medicine |
Publisher: | MDPI |
Place of publication: | Basel |
Editor: | Hugues Chabriat |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2022/10/01 |
Release Date: | 2022/11/14 |
Tag: | PSD; delirium; stroke; vascular risk factors |
GND Keyword: | - |
Volume: | 11 |
Issue: | 19 |
Article Number: | 5835 |
Page Number: | 14 |
Faculties: | Universitätsmedizin / Klinik und Poliklinik für Neurologie |
Licence (German): | Creative Commons - Namensnennung |