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Conductive Gas Plasma Treatment Augments Tumor Toxicity of Ringer’s Lactate Solutions in a Model of Peritoneal Carcinomatosis
- Reactive species generated by medical gas plasma technology can be enriched in liquids for use in oncology targeting disseminated malignancies, such as metastatic colorectal cancer. Notwithstanding, reactive species quantities depend on the treatment mode, and we recently showed gas plasma exposure in conductive modes to be superior for cancer tissue treatment. However, evidence is lacking that such a conductive mode also equips gas plasma-treated liquids to confer augmented intraperitoneal anticancer activity. To this end, employing atmospheric pressure argon plasma jet kINPen-treated Ringer’s lactate (oxRilac) in a CT26-model of colorectal peritoneal carcinomatosis, we tested repeated intraabdominal injection of such remotely or conductively oxidized liquid for antitumor control and immunomodulation. Enhanced reactive species formation in conductive mode correlated with reduced tumor burden in vivo, emphasizing the advantage of conduction over the free mode for plasma-conditioned liquids. Interestingly, the infiltration of lymphocytes into the tumors was equally enhanced by both treatments. However, significantly lower levels of interleukin (IL)4 and IL13 and increased levels of IL2 argue for a shift in intratumoral T-helper cell subpopulations correlating with disease control. In conclusion, our data argue for using conductively over remotely prepared plasma-treated liquids for anticancer treatment.
Author: | Lea Miebach, Eric FreundORCiD, Alessandra Lourenço Cecchini, Sander BekeschusORCiD |
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URN: | urn:nbn:de:gbv:9-opus-63924 |
DOI: | https://doi.org/10.3390/antiox11081439 |
ISSN: | 2076-3921 |
Parent Title (English): | Antioxidants |
Publisher: | MDPI |
Place of publication: | Basel |
Editor: | Luís Fernando Barbisan, Maria Aparecida Marchesan Rodrigues, Guilherme Ribeiro Romualdo |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2022/07/25 |
Release Date: | 2022/11/17 |
Tag: | ROS; colorectal cancer; cytokines; immunogenicity; plasma medicine; reactive oxygen species |
GND Keyword: | - |
Volume: | 11 |
Issue: | 8 |
Page Number: | 13 |
Faculties: | Universitätsmedizin / Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie/Plastische Operationen |
Licence (German): | Creative Commons - Namensnennung |