Refine
Year of publication
- 2015 (79) (remove)
Document Type
- Doctoral Thesis (50)
- Article (28)
- Conference Proceeding (1)
Language
- English (79) (remove)
Is part of the Bibliography
- no (79)
Keywords
- - (29)
- IPMN (3)
- Intraductal papillary mucinous neoplasm (3)
- Antikörper (2)
- Bach Ma Nationalpark (2)
- Biokatalyse (2)
- Depression (2)
- Enzym (2)
- Geopolymer (2)
- Germany (2)
Institute
- Institut für Physik (14)
- Abteilung für Mikrobiologie und Molekularbiologie (6)
- Institut für Geographie und Geologie (6)
- Kliniken und Polikliniken für Innere Medizin (6)
- Institut für Biochemie (4)
- Institut für Mikrobiologie - Abteilung für Genetik & Biochemie (4)
- Zoologisches Institut und Museum (4)
- Institut für Mathematik und Informatik (3)
- Institut für Psychologie (3)
- Institut für Botanik und Landschaftsökologie & Botanischer Garten (2)
- Institut für Immunologie u. Transfusionsmedizin - Abteilung Transfusionsmedizin (2)
- Interfakultäres Institut für Genetik und Funktionelle Genomforschung (UMG) (2)
- Klinik und Poliklinik für Neurologie (2)
- Poliklinik für Zahnerhaltung, Parodontologie und Endodontologie (2)
- Rechtswissenschaften (2)
- Institut für Community Medicine (1)
- Institut für Epidemiologie u. Sozialmedizin (1)
- Institut für Erziehungswissenschaft (1)
- Institut für Geologische Wissenschaften (1)
- Institut für Immunologie u. Transfusionsmedizin - Abteilung Immunologie (1)
- Institut für Pharmazie (1)
- Klinik für Anästhesiologie und Intensivmedizin (1)
- Klinik für Psychiatrie und Psychotherapie (1)
- Klinik und Poliklinik für Chirurgie Abt. für Unfall- und Wiederherstellungschirurgie (1)
- Klinik und Poliklinik für Frauenheilkunde u. Geburtshilfe (1)
- Klinik und Poliklinik für Innere Medizin Abt. Gastroenterologie, Endokrinologie und Ernährungsmedizin (1)
- Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie/Plastische Operationen (1)
- Klinik und Poliklinik für Urologie (1)
- Poliklinik für Kieferorthopädie, Präventive Zahnmedizin und Kinderzahnheilkunde (1)
- Wirtschaftswissenschaften (1)
Publisher
- S. Karger AG (17)
- Frontiers Media S.A. (5)
- IOP Publishing (5)
- De Gruyter (2)
‘Chameleonic' Serological Findings Leading to Life-Threatening Hemolytic Transfusion Reactions
(2015)
Background: The phenomena of co-incidence of transfusion-induced allo- and autoantibodies, blockage and/or loss of red blood cell (RBC) antigens are conspicuous and may result in confusion and misdiagnosis. Case Report: A 67-year-old female was transferred to the intensive care unit due to hemolysis which developed 2 days following transfusion of three Rh(D)-negative RBC units in the presence of strongly reactive autoantibodies. Standard serological testing and genotyping were performed. Upon arrival, the patient was typed as Ccddee. Her hemolysis was decompensated, and an immediate blood transfusion was required. In addition, direct and indirect antiglobulin tests (DAT and IAT) as well as the eluate were strongly positive. Emergency transfusion of Rh(D)-negative RBCs resulted in increased hemolysis and renal failure. An exhaustive testing revealed anti-D, anti-c, CCddee phenotype and CCD.ee genotype. Three units of cryopreserved CCddee RBCs were transfused, and the patient's condition immediately improved. The discrepancy between Rh-D phenotyping and genotyping was likely caused by masking of the D-epitopes by the autoantibodies. In fact, further enquiry revealed that the patient had been phenotyped as Rh(D)-positive 6 months ago and had been transfused at that time following hip surgery. Conclusion: The phenomena of transfusion-induced autoantibodies, masked alloantibodies, antigen blockage and/or loss are rare but important features which should be considered in patients presenting with autoimmune hemolytic anemia and/or hemolytic transfusion reactions.