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α-Dioxygenases (α-DOXs): Promising Biocatalysts for the Environmentally Friendly Production of Aroma Compounds
- Fatty aldehydes (FALs) can be derived from fatty acids (FAs) and related compounds and are frequently used as flavors and fragrances. Although chemical methods have been conventionally used, their selective biotechnological production aiming at more efficient and eco-friendly synthetic routes is in demand. α-Dioxygenases (α-DOXs) are heme-dependent oxidative enzymes biologically involved in the initial step of plant FA α-oxidation during which molecular oxygen is incorporated into the Cα-position of a FA (Cn) to generate the intermediate FA hydroperoxide, which is subsequently converted into the shortened corresponding FAL (Cn-1). α-DOXs are promising biocatalysts for the flavor and fragrance industries, they do not require NAD(P)H as cofactors or redox partner proteins, and they have a broad substrate scope. Here, we highlight recent advances in the biocatalytic utilization of α-DOXs with emphasis on newly discovered cyanobacterial α-DOXs as well as analytical methods to measure α-DOX activity in vitro and in vivo.
Author: | In Jung Kim, Thomas Bayer, Henrik Terholsen, Uwe T. BornscheuerORCiD |
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URN: | urn:nbn:de:gbv:9-opus-106731 |
DOI: | https://doi.org/10.1002/cbic.202100693 |
ISSN: | 1439-7633 |
Parent Title (English): | ChemBioChem |
Publisher: | Wiley |
Place of publication: | Hoboken, NJ |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2022/02/02 |
Date of first Publication: | 2022/06/20 |
Release Date: | 2024/02/19 |
Tag: | (high-throughput) aldehyde detection; alpha-dioxygenase; aroma compounds; cyanobacteria; fatty acids; fatty aldehydes |
Volume: | 23 |
Issue: | 12 |
Article Number: | e202100693 |
Page Number: | 11 |
Faculties: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie |
Collections: | weitere DFG-förderfähige Artikel |
Licence (German): | Creative Commons - Namensnennung 4.0 International |