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Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-75685

A multivariable prediction model for recovery patterns and time course of symptoms improvement in hemifacial spasm following microvascular decompression

  • Background: Microvascular decompression (MVD) success rates exceed 90% in hemifacial spasm (HFS). However, postoperative recovery patterns and durations are variable. Objective: We aim to study factors that might influence the postoperative patterns and duration needed until final recovery. Method: Only patients following de-novo MVD with a minimum follow-up of 6 months were included. Overall trend of recovery was modeled. Patients were grouped according to recognizable clinical recovery patterns. Uni- and multivariable analyses were used to identify the factors affecting allocation to the identified patterns and time needed to final recovery. Results: 323(92.6%) patients had >90% symptom improvement and 269(77.1%) patients had complete resolution at the last follow–up. The overall trend of recovery showed steep remission within the first 6 months, followed by relapse peaking around 8 months with a second remission ~16 months. Five main recovery patterns were identified. Patterns analysis showed that evident proximal indentation of the facial nerve at REZ, males and facial palsy are associated with earlier recovery at multivariable and univariable levels. AICA, AICA/VA compressions and shorter disease durations are related to immediate resolution of the symptoms only on the univariable level. Time analysis showed that proximal indentation (vs. distal indentation), males and facial palsy witnessed significantly earlier recoveries. Conclusion: Our main finding is that in contrast to peripheral indentation, proximal indentation of the facial nerve at REZ is associated with earlier recovery. Postoperative facial palsy and AICA compressions are associated with earlier recoveries. We recommend a minimum of 1 year before evaluating the final outcome of MVD for HFS.

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Metadaten
Author: Ahmed ALMenabbawy Mohamed
URN:urn:nbn:de:gbv:9-opus-75685
Title Additional (German):Ein multivariables Vorhersagemodell für Erholungsmuster und den zeitlichen Verlauf der Symptomverbesserung bei Spasmus hemifacialis nach mikrovaskulärer Dekompression
Referee:Prof. Dr. Henry Schroeder, Prof. Dr. Agnes FlöelORCiD, Prof. Dr. Taras Usichenko
Advisor:Prof. Dr. Henry Schroeder
Document Type:Doctoral Thesis
Language:English
Year of Completion:2022
Date of first Publication:2022/10/19
Granting Institution:Universität Greifswald, Universitätsmedizin
Date of final exam:2022/08/15
Release Date:2022/10/19
GND Keyword:Microvascular decompression, hemifacial spasm, delayed recovery, time course of recovery
Faculties:Universitätsmedizin / Klinik und Poliklinik für Neurochirurgie
DDC class:600 Technik, Medizin, angewandte Wissenschaften / 610 Medizin und Gesundheit