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Macrophages: shapes and functions
- Macrophages are cells of the innate immune system and represent an important component of the first-line defense against pathogens and tumor cells. Here, their diverse functions in inflammation and tumor defense are described, and the mechanisms, tools, and activation pathways and states applied are presented. The main focus is on the role and origin of reactive oxygen species (ROS), the important signal pathways TLR/NF-κB, and the M1/M2 polarization of macrophages.
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| Author: | Uwe Lendeckel, Simone Venz, Carmen Wolke |
|---|---|
| URN: | urn:nbn:de:gbv:9-opus-106914 |
| DOI: | https://doi.org/10.1007/s40828-022-00163-4 |
| ISSN: | 2199-3793 |
| Parent Title (English): | ChemTexts: The Textbook Journal of Chemistry |
| Publisher: | Springer Nature |
| Place of publication: | Berlin |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2022/03/10 |
| Date of first Publication: | 2022/04/01 |
| Release Date: | 2024/02/21 |
| Tag: | M1 macrophage; M2 macrophage; NF-κB signal transduction pathway; Oxidative burst; Phagocytosis; Reactive oxygen species; TLR4 signaling |
| Volume: | 8 |
| Issue: | 2 |
| Article Number: | 12 |
| Page Number: | 12 |
| Faculties: | Universitätsmedizin / Institut für Med. Biochemie u. Molekularbiologie |
| Collections: | weitere DFG-förderfähige Artikel |
| Licence (German): |  Creative Commons - Namensnennung 4.0 International |