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Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process
- Group B streptococci (GBS) cause a range of invasive maternal–fetal diseases during pregnancy and post-partum. However, invasive infections in non-pregnant adults are constantly increasing. These include sepsis and streptococcal toxic shock syndrome, which are often complicated by systemic coagulation and thrombocytopenia. GBS express a hyper-hemolytic ornithine rhamnolipid pigment toxin with cytolytic and coagulatory activity. Here, we investigated the effects of GBS pigment on human platelets. Infections of platelets with pigmented GBS resulted initially in platelet activation, followed by necrotic cell death. Thus, this study shows that GBS pigment kills human platelets.
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| Author: | Kristin Jahn, Patience Shumba, Phoenicia Quach, Mathias Müsken, Jan Wesche, Andreas GreinacherORCiD, Lakshmi Rajagopal, Sven HammerschmidtORCiD, Nikolai Siemens |
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| URN: | urn:nbn:de:gbv:9-opus-62735 |
| DOI: | https://doi.org/10.3390/cells11101637 |
| ISSN: | 2073-4409 |
| Parent Title (English): | Cells |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of first Publication: | 2022/05/13 |
| Release Date: | 2022/11/15 |
| Tag: | group B streptococcus; pigment; platelets |
| Volume: | 11 |
| Issue: | 10 |
| Article Number: | 1637 |
| Page Number: | 12 |
| Faculties: | Mathematisch-Naturwissenschaftliche Fakultät / Interfakultäres Institut für Genetik und Funktionelle Genomforschung (MNF) |
| Collections: | Artikel aus DFG-gefördertem Publikationsfonds |
| Licence (German): |  Creative Commons - Namensnennung |