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Structural integrity of the insula and emotional facial recognition performance following stroke
- The role of the human insula in facial emotion recognition is controversially discussed, especially in relation to lesion-location-dependent impairment following stroke. In addition, structural connectivity quantification of important white-matter tracts that link the insula to impairments in facial emotion recognition has not been investigated. In a case–control study, we investigated a group of 29 stroke patients in the chronic stage and 14 healthy age- and gender-matched controls. Lesion location of stroke patients was analysed with voxel-based lesion-symptom mapping. In addition, structural white-matter integrity for tracts between insula regions and their primarily known interconnected brain structures was quantified by tractography-based fractional anisotropy. Our behavioural analyses showed that stroke patients were impaired in the recognition of fearful, angry and happy but not disgusted expressions. Voxel-based lesion mapping revealed that especially lesions centred around the left anterior insula were associated with impaired recognition of emotional facial expressions. The structural integrity of insular white-matter connectivity was decreased for the left hemisphere and impaired recognition accuracy for angry and fearful expressions was associated with specific left-sided insular tracts. Taken together, these findings suggest that a multimodal investigation of structural alterations has the potential to deepen our understanding of emotion recognition impairments after stroke.
Author: | Kai Klepzig, Martin DominORCiD, Julia Wendt, Bettina von Sarnowski, Alexander Lischke, Alfons O. HammORCiD, Martin LotzeORCiD |
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URN: | urn:nbn:de:gbv:9-opus-105832 |
DOI: | https://doi.org/10.1093/braincomms/fcad144 |
ISSN: | 2632-1297 |
Parent Title (English): | Brain Communications |
Publisher: | Oxford University Press |
Place of publication: | Oxford |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2023/04/28 |
Release Date: | 2024/01/30 |
Tag: | brain lesion mapping; facial emotional recognition; insula; stroke; white-matter integrity |
Volume: | 5 |
Issue: | 3 |
Article Number: | fcad144 |
Page Number: | 14 |
Faculties: | Universitätsmedizin / Institut für Diagnostische Radiologie und Neuroradiologie |
Collections: | Artikel aus DFG-gefördertem Publikationsfonds |
Licence (German): | Creative Commons - Namensnennung |