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Redox-Regulation in Cancer Stem Cells
- Cancer stem cells (CSCs) represent a small subset of slowly dividing cells with tumor-initiating ability. They can self-renew and differentiate into all the distinct cell populations within a tumor. CSCs are naturally resistant to chemotherapy or radiotherapy. CSCs, thus, can repopulate a tumor after therapy and are responsible for recurrence of disease. Stemness manifests itself through, among other things, the expression of stem cell markers, the ability to induce sphere formation and tumor growth in vivo, and resistance to chemotherapeutics and irradiation. Stemness is maintained by keeping levels of reactive oxygen species (ROS) low, which is achieved by enhanced activity of antioxidant pathways. Here, cellular sources of ROS, antioxidant pathways employed by CSCs, and underlying mechanisms to overcome resistance are discussed.
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| Author: | Uwe Lendeckel, Carmen Wolke |
|---|---|
| URN: | urn:nbn:de:gbv:9-opus-105192 |
| DOI: | https://doi.org/10.3390/biomedicines10102413 |
| ISSN: | 2227-9059 |
| Parent Title (English): | Biomedicines |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of first Publication: | 2022/09/27 |
| Release Date: | 2024/01/22 |
| Tag: | CD13; Nrf2-sinaling; ROS; Sonic Hedgehog signaling; Wnt-signaling; antioxidant signaling pathways; cancer stem cell; drug resistance |
| Volume: | 10 |
| Issue: | 10 |
| Article Number: | 2413 |
| Page Number: | 17 |
| Faculties: | Universitätsmedizin / Institut für Med. Biochemie u. Molekularbiologie |
| Collections: | Artikel aus DFG-gefördertem Publikationsfonds |
| Licence (German): |  Creative Commons - Namensnennung |