Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-60834
Efficiency of a 15-Week Weight-Loss Program, Including a Low-Calorie Formula Diet, on Glycemic Control in Patients with Type 2 Diabetes Mellitus and Overweight or Obesity
- Introduction: Patients who are overweight or obese have an increased risk of developing type 2 diabetes mellitus (T2DM). Weight loss can have a positive effect on glycemic control. Objective: We aimed to investigate glycemic control in patients with T2DM and overweight or obesity during a structured weight-loss program. Methods: This was a prospective, interventional study. We recruited 36 patients (14 men and 22 women) with a median age of 58.5 years and median body mass index (BMI) of 34.1, to a 15-week structured weight-loss program with a low-calorie (800 kcal) formula diet for 6 weeks. The primary end point, HbA<sub>1c</sub> level, and secondary end points, anthropometric data, medication, and safety, were assessed weekly. Laboratory values and quality of life were assessed at baseline and after 15 weeks. Results: HbA<sub>1c</sub> decreased from 7.3% at baseline to 6.5% at 15 weeks (p < 0.001), median body weight by 11.9 kg (p < 0.001), median BMI by 4.3 (p < 0.001) and median waist circumference by 11.0 cm (p < 0.001). Two participants discontinued insulin therapy, 4 could reduce their dosage of oral antidiabetic agents, and 6 completely discontinued their antidiabetic medication. Insulin dose decreased from 0.63 (0.38–0.89) to 0.39 (0.15–0.70) units/kg body weight (p < 0.001). No patient experienced hypoglycemic episodes or hospital emergency visits. Triglycerides and total cholesterol decreased as well as surrogate markers of liver function. However, the levels of high-density and low-density lipoprotein cholesterol (HDL-C and LDL-C) as well as uric acid remain unchanged. Regarding quality of life, the median physical health score increased from 44.5 (39.7–51.4) at baseline to 48.0 (43.1–55.3; p = 0.007), and the median mental health score decreased from 42.1 (36.1–46.7) to 37.4 (30.3–43.7; p = 0.004). Conclusions: A structured weight-loss program is effective in the short term in reducing HbA<sub>1c</sub>, weight, and antidiabetic medication in patients with T2DM who are overweight or obese. Levels of HDL-C and LDL-C were not affected by short-term weight loss. The decline in mental health and the long-term effects of improved glycemic control require further trials.
Author: | Lena J. Storck, Peter J. Meffert, Janine Rausch, Simone Gärtner, Ali A. AghdassiORCiD, Jens-Peter Kühn, Matthias Kraft, Maik Pietzner, Markus M. LerchORCiD, Antje Steveling |
---|---|
URN: | urn:nbn:de:gbv:9-opus-60834 |
DOI: | https://doi.org/10.1159/000511453 |
ISSN: | 1662-4025 |
ISSN: | 1662-4033 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/33601371 |
Parent Title (English): | Obesity Facts |
Publisher: | S. Karger AG |
Place of publication: | Basel, Switzerland |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2021/02/18 |
Release Date: | 2022/12/01 |
Tag: | Diabetes mellitus; Formula diet; Medical treatment; Obesity; Quality of life |
GND Keyword: | - |
Volume: | 14 |
Issue: | 1 |
First Page: | 45 |
Last Page: | 55 |
Faculties: | Universitätsmedizin / Institut für Diagnostische Radiologie und Neuroradiologie |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung |