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Clinical research in dementia: A perspective on implementing innovation
- Abstract The increasing global prevalence of dementia demands concrete actions that are aimed strategically at optimizing processes that drive clinical innovation. The first step in this direction requires outlining hurdles in the transition from research to practice. The different parties needed to support translational processes have communication mismatches; methodological gaps hamper evidence‐based decision‐making; and data are insufficient to provide reliable estimates of long‐term health benefits and costs in decisional models. Pilot projects are tackling some of these gaps, but appropriate methods often still need to be devised or adapted to the dementia field. A consistent implementation perspective along the whole translational continuum, explicitly defined and shared among the relevant stakeholders, should overcome the “research‐versus‐adoption” dichotomy, and tackle the implementation cliff early on. Concrete next steps may consist of providing tools that support the effective participation of heterogeneous stakeholders and agreeing on a definition of clinical significance that facilitates the selection of proper outcome measures.
Author: | Marina Boccardi, Ron Handels, Michael Gold, Alice Grazia, Michael W. Lutz, Mike Martin, Rachel Nosheny, Julie M. Robillard, Wendy Weidner, Jan Alexandersson, Jochen René Thyrian, Bengt Winblad, Paola Barbarino, Ara S. Khachaturian, Stefan Teipel |
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URN: | urn:nbn:de:gbv:9-opus-76631 |
DOI: | https://doi.org/10.1002/alz.12622 |
ISSN: | 1552-5279 |
Parent Title (English): | Alzheimer's & Dementia |
Publisher: | Wiley |
Place of publication: | Hoboken, NJ |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2022/11/15 |
Release Date: | 2022/11/29 |
Tag: | Alzheimer's disease; clinical innovation; dementia; implementation; methodology; neurocognitive disorders; translational research |
GND Keyword: | - |
Volume: | 18 |
Issue: | 11 |
First Page: | 2352 |
Last Page: | 2367 |
Faculties: | Universitätsmedizin / Institut für Community Medicine |
Licence (German): | Creative Commons - Namensnennung |