Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-64965
Proteomics: A Tool to Study Platelet Function
- : Platelets are components of the blood that are highly reactive, and they quickly respond to multiple physiological and pathophysiological processes. In the last decade, it became clear that platelets are the key components of circulation, linking hemostasis, innate, and acquired immunity. Protein composition, localization, and activity are crucial for platelet function and regulation. The current state of mass spectrometry-based proteomics has tremendous potential to identify and quantify thousands of proteins from a minimal amount of material, unravel multiple post-translational modifications, and monitor platelet activity during drug treatments. This review focuses on the role of proteomics in understanding the molecular basics of the classical and newly emerging functions of platelets. including the recently described role of platelets in immunology and the development of COVID-19.The state-of-the-art proteomic technologies and their application in studying platelet biogenesis, signaling, and storage are described, and the potential of newly appeared trapped ion mobility spectrometry (TIMS) is highlighted. Additionally, implementing proteomic methods in platelet transfusion medicine, and as a diagnostic and prognostic tool, is discussed.
Author: | Olga Shevchuk, Antonija Jurak Begonja, Stepan Gambaryan, Matthias Totzeck, Tienush Rassaf, Tobias B. Huber, Andreas GreinacherORCiD, Thomas Renne, Albert Sickmann |
---|---|
URN: | urn:nbn:de:gbv:9-opus-64965 |
DOI: | https://doi.org/10.3390/ijms22094776 |
ISSN: | 1422-0067 |
Parent Title (English): | International Journal of Molecular Sciences |
Publisher: | MDPI |
Place of publication: | Basel |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2021/04/30 |
Release Date: | 2022/11/22 |
Tag: | LC-MS/MS; PTMs; mass spectrometry; phosphoproteomics; platelet transfusion proteomics; platelets; precision medicine; signaling; targeted proteomics |
GND Keyword: | - |
Volume: | 22 |
Issue: | 9 |
Page Number: | 25 |
Faculties: | Universitätsmedizin / Institut für Immunologie u. Transfusionsmedizin - Abteilung Immunologie |
Licence (German): | Creative Commons - Namensnennung |