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Thermodynamic Stability of G‐Quadruplexes: Impact of Sequence and Environment
- Abstract G‐quadruplexes have attracted growing interest in recent years due to their occurrence in vivo and their possible biological functions. In addition to being promising targets for drug design, these four‐stranded nucleic acid structures have also been recognized as versatile tools for various technological applications. Whereas a large number of studies have yielded insight into their remarkable structural diversity, our current knowledge on G‐quadruplex stabilities as a function of sequence and environmental factors only gradually emerges with an expanding collection of thermodynamic data. This minireview provides an overview of general rules that may be used to better evaluate quadruplex thermodynamic stabilities but also discusses present challenges in predicting most stable folds for a given sequence and environment.
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| Author: | Jagannath Jana, Klaus Weisz |
|---|---|
| URN: | urn:nbn:de:gbv:9-opus-60484 |
| DOI: | https://doi.org/10.1002/cbic.202100127 |
| ISSN: | 1439-7633 |
| Parent Title (English): | ChemBioChem |
| Publisher: | Wiley |
| Place of publication: | Hoboken, NJ |
| Document Type: | Article |
| Language: | English |
| Date of first Publication: | 2021/10/03 |
| Release Date: | 2022/11/30 |
| Tag: | DNA; G-quadruplexes; calorimetry; thermodynamics; topology |
| Volume: | 22 |
| Issue: | 19 |
| Page Number: | 9 |
| First Page: | 2848 |
| Last Page: | 2856 |
| Faculties: | Universitätsmedizin / Institut für Med. Biochemie u. Molekularbiologie |
| Licence (German): |  Creative Commons - Namensnennung |