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Connecting Algal Polysaccharide Degradation to Formaldehyde Detoxification
- Formaldehyde is a toxic metabolite that is formed in large quantities during bacterial utilization of the methoxy sugar 6-O-methyl-d-galactose, an abundant monosaccharide in the red algal polysaccharide porphyran. Marine bacteria capable of metabolizing porphyran must therefore possess suitable detoxification systems for formaldehyde. We demonstrate here that detoxification of formaldehyde in the marine Flavobacterium Zobellia galactanivorans proceeds via the ribulose monophosphate pathway. Simultaneously, we show that the genes encoding the key enzymes of this pathway are important for maintaining high formaldehyde resistance. Additionally, these genes are upregulated in the presence of porphyran, allowing us to connect porphyran degradation to the detoxification of formed formaldehyde.
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| Author: | Stefan Brott, François Thomas, Maike Behrens, Karen Methling, Daniel Bartosik, Theresa Dutschei, Michael LalkORCiD, Gurvan Michel, Thomas Schweder, Uwe T. BornscheuerORCiD |
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| URN: | urn:nbn:de:gbv:9-opus-107122 |
| DOI: | https://doi.org/10.1002/cbic.202200269 |
| ISSN: | 1439-7633 |
| Parent Title (English): | ChemBioChem |
| Publisher: | Wiley |
| Place of publication: | Hoboken, NJ |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2022/05/13 |
| Date of first Publication: | 2022/07/19 |
| Release Date: | 2024/02/22 |
| Tag: | Bacteroidetes; CAZymes formaldehyde detoxification; RuMP pathway; carbohydrates |
| Volume: | 23 |
| Issue: | 14 |
| Article Number: | e202200269 |
| Page Number: | 6 |
| Faculties: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie |
| Collections: | weitere DFG-förderfähige Artikel |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 4.0 International |