Refine
Document Type
- Article (9)
- Doctoral Thesis (1)
Language
- English (10)
Has Fulltext
- yes (10)
Is part of the Bibliography
- no (10)
Keywords
- - (5)
- antibody (2)
- colonization (2)
- proteomics (2)
- ADCC (1)
- AICC (1)
- BCL11B (1)
- CC88 (1)
- CRISPR/Cas (1)
- GWA (1)
Institute
- Interfakultäres Institut für Genetik und Funktionelle Genomforschung (MNF) (3)
- Interfakultäres Institut für Genetik und Funktionelle Genomforschung (UMG) (3)
- Institut für Immunologie u. Transfusionsmedizin - Abteilung Immunologie (2)
- Abteilung für Mikrobiologie und Molekularbiologie (1)
- Institut für Botanik und Landschaftsökologie & Botanischer Garten (1)
- Institut für Immunologie u. Transfusionsmedizin - Abteilung Transfusionsmedizin (1)
- Kliniken und Polikliniken für Innere Medizin (1)
Publisher
Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus. A well-known risk factor is the lack of neutralizing antibodies. To identify determinants of the anti-TSST-1 antibody response, we examined 976 participants of the German population-based epidemiological Study of Health in Pomerania (SHIP-TREND-0). We measured anti-TSST-1 antibody levels, analyzed the colonization with TSST-1-encoding S. aureus strains, and performed a genome-wide association analysis of genetic risk factors. TSST-1-specific serum IgG levels varied over a range of 4.2 logs and were elevated by a factor of 12.3 upon nasal colonization with TSST-1-encoding S. aureus. Moreover, the anti-TSST-1 antibody levels were strongly associated with HLA class II gene loci. HLA-DRB1*03:01 and HLA-DQB1*02:01 were positively, and HLA-DRB1*01:01 as well as HLA-DQB1*05:01 negatively associated with the anti-TSST-1 antibody levels. Thus, both toxin exposure and HLA alleles affect the human antibody response to TSST-1.