Refine
Year of publication
- 2011 (202) (remove)
Document Type
- Doctoral Thesis (181)
- Article (20)
- Course Material (1)
Has Fulltext
- yes (202)
Is part of the Bibliography
- no (202)
Keywords
- - (19)
- Sepsis (6)
- Genexpression (5)
- Lebensqualität (5)
- Prävention (5)
- Staphylococcus aureus (5)
- Biosphärenreservat (4)
- Endothel (4)
- Nursing bottle syndrom (4)
- Proteomanalyse (4)
- Ratte (4)
- Antikörper (3)
- Diabetes mellitus (3)
- Epidemiologie (3)
- Frühgeborene (3)
- Kieferhöhle (3)
- Klimaänderung (3)
- Parodontitis (3)
- Ultraschall (3)
- Virulenz (3)
- Akute Bauchspeicheldrüsenentzündung (2)
- Alexithymie (2)
- Alkohol (2)
- Alter (2)
- Anatomie (2)
- Antiseptik (2)
- Atmosphärendruckplasma (2)
- BALB/c Maus (2)
- Biatain Ag (2)
- Bildgebung (2)
- CMD (2)
- Chronisch-venöse Insuffizienz (2)
- Computertomographie (2)
- Depression (2)
- Elektronenmikroskopie (2)
- Endotoxin (2)
- Entzündung (2)
- Evolution (2)
- Fernröntgenseitenbild (2)
- Fettleber (2)
- Funktionelle NMR-Tomographie (2)
- Greifswald / Universität (2)
- Heparin (2)
- Honig (2)
- Hypertonie (2)
- Immunologie (2)
- Immunreaktion (2)
- Impfung (2)
- Inhibition (2)
- Insulin-like Growth Factor I (2)
- Intravitalmikroskopie (2)
- Karies (2)
- Kiefergelenk (2)
- Kindergarten (2)
- Kinderzahnheilkunde (2)
- Kopfschmerz (2)
- LOX-1 (2)
- Lungenkrebs (2)
- MRSA (2)
- Morphologie (2)
- Multiple Sklerose (2)
- NADPH-Oxidase (2)
- Nationalsozialismus (2)
- Naturstoff (2)
- Niedermolekulares Heparin (2)
- Okklusion (2)
- Pancreatic cancer (2)
- Phosphine (2)
- Polytrauma (2)
- Primaten (2)
- Proteindesign (2)
- Proteolyse (2)
- Ratten (2)
- Rauchen (2)
- Schilddrüse (2)
- Sinus maxillaris (2)
- Tiermodell (2)
- Tierversuch (2)
- Titan (2)
- Trauma (2)
- Validierung (2)
- Wachstum (2)
- Zahnpflege (2)
- Zufriedenheit (2)
- cleft lip and palate (2)
- endotoxemia (2)
- fMRI (2)
- fMRT (2)
- maxillary sinus (2)
- occlusion (2)
- rat (2)
- reconstruction (2)
- 3-dioxygenase (1)
- 31P-NMR (1)
- 6606PDA (1)
- ACDA (1)
- ACDF (1)
- AFLP (1)
- AKT/mTOR activation (1)
- AKT/mTOR-Signalweg (1)
- Ab-initio-Rechnung (1)
- Ablation <Medizin> (1)
- Acute pancreatitis (1)
- Acylhydrazone (1)
- Adaptation (1)
- Adenylylcyclase (1)
- Aerosol (1)
- Aggregatibacter actinomycetemcomitans (1)
- Akademie der Wissenschaften (1)
- Akkreditierung (1)
- Akute lymphatische Leukämie (1)
- Akute-Phase-Reaktion (1)
- Akutes Koronarsyndrom (1)
- Albuminuria (1)
- Alexithymia (1)
- Alignment <Biochemie> (1)
- Alkaloide (1)
- Alkoholkonsum (1)
- Allelspezifische Expression (1)
- Allergie (1)
- Allogeneic stem cell transplantation (1)
- Allversöhnung (1)
- Altenpflege (1)
- Altweltaffen (1)
- Alveolarmakrophage (1)
- Ambulante Behandlung (1)
- Ambulanter Hilfs- und Pflegedienst (1)
- Aminosäuren (1)
- Aminosäurenstoffwechsel (1)
- Amitriptylin (1)
- Amt für Kernforschung und Kerntechnik (1)
- Anaerobiose (1)
- Analytische Chemie (1)
- Anforderungsverhalten (1)
- Angeborene Immunität (1)
- Angiogenese (1)
- Angiographie (1)
- Angiotensin II (1)
- Angst (1)
- Angststörung (1)
- Anodische Oxidation <Oberflächenbehandlung> (1)
- Anpassung (1)
- Anthropogene Klimaänderung (1)
- Anti-Human-Globulin-Kreuzprobe (1)
- Antibiotikum (1)
- Antigen-Antikörper-Reaktion (1)
- Antikoagulation (1)
- Antikörperbildung (1)
- Antimicrobial efficacy (1)
- Antimikrobiel (1)
- Antiterminator-Proteine (1)
- Antonio Antoniotti (1)
- Anämie (1)
- Aorta (1)
- Aortenklappenersatz (1)
- Aortokoronarer Bypass (1)
- Apocynin (1)
- Apokatastasis (1)
- Apoptosis (1)
- Apotheker (1)
- Argatroban (1)
- Arteriosklerose (1)
- Arzt-Patienten-Beziehung (1)
- Arzt-Patienten-Gespräch (1)
- Assoziation. Bevölkerungsbezogene Studie (1)
- Atropa belladonna (1)
- Atropin (1)
- Aufstellung <Zahntechnik> (1)
- Augenantiseptik (1)
- Augenheilkunde (1)
- Augenmuskeln (1)
- Autofluorescence (1)
- Autoimmune pancreatitis (1)
- Avian Influenza Virus (1)
- Aviäre Influenza Viren (1)
- Azaphospholderivat (1)
- BALB/c mouse (1)
- BCRP (1)
- Bacillus (1)
- Bacteria (1)
- Bakterielle Infektion (1)
- Bakterien (1)
- Bakteriämie (1)
- Bandscheibenendoprothetik (1)
- Bandscheibenvorfall (1)
- Basedow-Krankheit (1)
- Basisemotionen (1)
- Bauchfellentzündung (1)
- Bauchspeicheldrüsenentzündung (1)
- Bauchspeicheldrüsenkrebs (1)
- Beckenschiefstand (1)
- Befragung (1)
- Belastungsblutdruck (1)
- Belastungssituation in der Pflege (1)
- Belohnung (1)
- Benzazaphosphole (1)
- Berlin / Robert-Koch-Institut (1)
- Beta-Blocker (1)
- Bewegungsanalyse (1)
- Biaryle (1)
- Bio (1)
- Bio-Siegel (1)
- Biodiversity (1)
- Biodiversität (1)
- Biofilm (1)
- Bioinformatics (1)
- Bioinformatik (1)
- Biokatalyse (1)
- Biokonversion (1)
- Biology and Natural Sciences (1)
- Biosphärenreservate (1)
- Blutdruck (1)
- Blutkonserve (1)
- Bluttransfusion (1)
- Borkenkäfer (1)
- Bronchialasthma (1)
- Brustkrebs (1)
- Burkholderia pseudomallei (1)
- CT (1)
- CXCL4 (1)
- CXCL4L1 (1)
- Calcium (1)
- Calcium-ATPasen (1)
- Calciumhomöostase (1)
- Carcinogenese (1)
- Caspase-1 (1)
- Cerclagen (1)
- Cerclagen2 (1)
- Cerulein (1)
- Chelate (1)
- Child's dental booklet (1)
- Chlamydophila pneumoniae (1)
- Cholestasis (1)
- Chondroitinsulfat (1)
- Chromosomal aberrations (1)
- Chromosomenaberration (1)
- Chromosomenanalyse (1)
- Chronic neuropathic pain (1)
- Chronic pancreatitis (1)
- Chronisch Kranker (1)
- Citrus fruits (1)
- Clarithromycin (1)
- Clinical pathway (1)
- Cluster (1)
- Coilembolisation (1)
- Common bile duct ligation (1)
- Community ecology (1)
- Compliance <Patient> (1)
- Computerexpertensystem (1)
- Computerphysik (1)
- Comutertomografie (1)
- Conditioning therapy (1)
- Congenital hyperinsulinism (1)
- Conservation biology (1)
- Corticosteron (1)
- Costing (1)
- Cyclisation (1)
- Cytokin (1)
- Cytokine (1)
- Cytokines (1)
- D (1)
- DEREG (1)
- DEXA-Messung (1)
- DFT (1)
- DNA Triplex (1)
- DNA triplex (1)
- DNA-Wirkstoff-Interaktion (1)
- DNA-drug interaction (1)
- DNS (1)
- Darby (1)
- Darmverletzung (1)
- Deformierung (1)
- Dehydrocyclisation (1)
- Deklination (1)
- Dekontamination (1)
- Dementia (1)
- Demenz (1)
- Dentaleinheit (1)
- Depotfett (1)
- Dermatologie (1)
- Desinfektion (1)
- Deutocerebrum (1)
- Deutschland <DDR> (1)
- Diabetesfuß (1)
- Diabetic foot syndrom (1)
- Diabetisches Fußsyndrom (1)
- Diagnose (1)
- Diagnostic criteria (1)
- Diagnostik (1)
- Diffuse congenital hyperinsulinism (1)
- Digitale Volumentomographie (1)
- Dimorphismus (1)
- Diskursanalyse (1)
- Dispersionsrelation (1)
- Dissertation (1)
- Distriktkrankenhaus (1)
- Divergent response (1)
- Dopamin (1)
- Drei-Stufen-Röhrchentest (1)
- Duchenne Muskeldystrophie (1)
- Duchenne-Syndrom (1)
- Durchführbarkeit (1)
- Durchimpfung (1)
- Dynamische Gefäßanalyse (1)
- Dämpfung (1)
- E.coli (1)
- ECC (1)
- EQ 5-D (1)
- EXCEL 2002 (1)
- EXCEL 2003 (1)
- Einflussgröße (1)
- Eisenmangel (1)
- Eisenst (1)
- Elektrochemische Oxidation (1)
- Embolisation (1)
- Emotionale Intelligenz (1)
- Empirische Sozialforschung (1)
- Endothelin (1)
- Endotoxikose (1)
- Endotoxinämie (1)
- Energy supply (1)
- Engraftment (1)
- Environmental risk factors (1)
- Environmental toxins (1)
- Enzyminhibitor (1)
- Epilepsie (1)
- Erfolgsfaktor (1)
- Erkennen (1)
- Ernährung (1)
- Erweckungsbewegung (1)
- Eschatologie (1)
- Estimated glomerular filtration rate (1)
- Estland (1)
- Estnisch (1)
- Estonia (1)
- Ethylene oligomerisation (1)
- Ethylenoligomerisation (1)
- Evolution der Genregulation (1)
- Evolution of Gene Regulation (1)
- Ex vivo (1)
- Experimental pain (1)
- Experimenteller Schmerz (1)
- Expertensystem (1)
- Exposition (1)
- Expositionsmessung (1)
- Expressed Emotion (1)
- Expressionsanalyse (1)
- Exspiration (1)
- Extrakt (1)
- FCD (1)
- Facettendenervation (1)
- Facettengelenk (1)
- Facial Emotion Recognition (1)
- Familienpflege <Sozialarbeit> (1)
- Fatiguesyndrom (1)
- Fehldiagnosen (1)
- Femtosecond laser (1)
- Ferritin (1)
- Ferritinindex (1)
- Fett (1)
- Fettquantifizierung (1)
- Fettsucht (1)
- Fibrinogen (1)
- Fibroadenom (1)
- Fibrosis (1)
- Filtration (1)
- Fine tiling comparative genomic hybridization (1)
- Fixateur externe (1)
- Fixateur interne (1)
- Flavonols (1)
- Fluoreszenzaktivierter Zellsortierer (1)
- Fluoxetin (1)
- Focal congenital hyperinsulinism (1)
- Folsäure (1)
- Formenlehre (1)
- Fortifier (1)
- Foxp3 (1)
- Fraktal (1)
- Friedrich (Arzt) (1)
- Frühgeborenes (1)
- Frühkindliche Karies (1)
- Fullerene (1)
- Fungi (1)
- Funktionseinheit (1)
- Fusion (1)
- Fähigkeitenansatz (1)
- GDR (1)
- Gastrointestinalblutung (1)
- Geburtsoutcome (1)
- Gebärmutterhalskrebs (1)
- Geflügel (1)
- Geflügelpestvirus (1)
- Gelkartentest (1)
- Gemeinschaftsbewegung (1)
- Genetic Evolution (1)
- Genetik (1)
- Genetisches Imprinting (1)
- Genregulation (1)
- Geochemie (1)
- Germany (1)
- Geschlechtsdimorphismus (1)
- Geschlechtsunterschied (1)
- Gesichtererkennung (1)
- Gesichtsschmerz (1)
- Gesichtsschädelvolumen (1)
- Gesichtsspalte (1)
- Gespräch (1)
- Gesundheitssystem (1)
- Gesundheitsverhalten (1)
- Gesundheitswesen (1)
- Gewichtsentwicklung (1)
- Gewichtsverlust (1)
- Gewichtszunahme (1)
- Gibbon (1)
- Giovanni Battista (1)
- Glatte Muskulatur (1)
- Gliederfüßer (1)
- Glutaminstoffwechsel (1)
- Glutamintransporter GlnQPH (1)
- Glutathionperoxidase (1)
- Glycine (1)
- Graft-versus-Leukämie Effekt (1)
- Grammatik (1)
- Graphenzeichnen (1)
- Grauer Star (1)
- Greifswald / Klinikum (1)
- Greifswalder Universitäts-Hautklinik (1)
- Grundschule (1)
- H9C2 (1)
- HEK (1)
- HPV vaccination (1)
- HPV-Impfung (1)
- HaCaT (1)
- Haftverbund (1)
- Hair follicle (1)
- Haloalkan Dehalogenase (1)
- Harnstoff (1)
- Hausa (1)
- Hauspflege (1)
- Hausstaub (1)
- Hautbarriere (1)
- Hautfeuchtigkeit (1)
- Hautklinik (1)
- Hautzelle (1)
- Heavy User (1)
- Heparin-induced thrombocytopenia (1)
- Hepatokarzinogenese (1)
- Herpesvirus (1)
- Herpesvirus suis (1)
- Herstellungsverfahren (1)
- Herzinfarkt (1)
- Heterologe Genexpression (1)
- High Utiliser (1)
- Hindernis (1)
- Histidin (1)
- Histidinphosphorylierung (1)
- Histologie (1)
- Hochfrequenzplasma (1)
- Hochland von Tibet (1)
- Hochschulschrift (1)
- Homöopathisches Arzneibuch (1)
- Humanes Papillomavirus (1)
- Hundertfüßer (1)
- Huvec (1)
- Hybrid ligand (1)
- Hygienestandard (1)
- Hylobatidae (1)
- Hypernephrom (1)
- Hyperthyreose (1)
- Hypophyse (1)
- Hypotension (1)
- Hämagglutinin (1)
- Hämoglobin (1)
- Hämolyse (1)
- ICAM (1)
- IL-10 (1)
- IL6 (1)
- ITN (1)
- Idiopathic duct-centric pancreatitis (1)
- Idiopathische pulmonale Fibrose (1)
- Imaging (1)
- Immuncytochemie (1)
- Immunmodulation (1)
- Immunoblot (1)
- Immunocompetent mice (1)
- Immunsuppression (1)
- Immunsystem (1)
- Impfbereitschaft (1)
- Impfstoff (1)
- Impfverhalten (1)
- In vitro (1)
- In vivo (1)
- In vivo imaging (1)
- In vivo laser scanning microscopy (1)
- Inanspruchnahme (1)
- Inanspruchnahme medizinischer Hilfe (1)
- Inanspruchnahmemotivation (1)
- Indirekter Coomb's Test (1)
- Indolamin-2 (1)
- Indolochinolin (1)
- Indonesia (1)
- Indonesian marine fungi (1)
- Indonesien (1)
- Induktion (1)
- Infektanfälligkeit (1)
- Influenza-A-Virus (1)
- Insekten (1)
- Institut für Kernforschung (1)
- Integrationspolitik (1)
- Intensivtherapie (1)
- Interpenetrierendes polymeres Netzwerk (1)
- Intervention (1)
- Intervention <Medizin> (1)
- Interventionsradiologie (1)
- Iodine status (1)
- Iodresorption (1)
- Ionenfalle (1)
- Ionenkanal (1)
- Isomer (1)
- Isotopolog Profiling (1)
- Israeltheologie (1)
- Japanmakak (1)
- Javaneraffe (1)
- Judenmission (1)
- KIMS (1)
- KSS (1)
- Kalamität (1)
- Kaltes Plasma (1)
- Kariesprävalenz (1)
- Kasus (1)
- Katarakt (1)
- Keramik (1)
- Keratose (1)
- Keratosen (1)
- Keratosis actinica (1)
- Kernenergie (1)
- Kernforschung (1)
- Kernphysik (1)
- Kerntechnik (1)
- Kidney disease (1)
- Kiefergelenk-Dysfunktions-Syndrom (1)
- Kiefergelenkkrankheit (1)
- Kiefergelenkschmerz (1)
- Kieferorthopädie (1)
- Kinderchirurgie (1)
- Kinderkrippe (1)
- Kindersoldat1 (1)
- Kirschner wire (1)
- Kirschnerdraht (1)
- Kleinkind (1)
- Klinischer Behandlungspfad (1)
- Klinisches Labor (1)
- Kniegelenkprothese (1)
- Knochendichte (1)
- Knochenersatzmaterial (1)
- Knochenzement (1)
- Kochsalz (1)
- Kohlenstoff (1)
- Kokultur (1)
- Kombinatorische Synthese (1)
- Komplexes Plasma (1)
- Kompressionsbehandlung (1)
- Kompressionsstrumpf (1)
- Konjugation (1)
- Kontrollierte klinische Studie (1)
- Konversationsanalyse (1)
- Kostenanalyse (1)
- Kraftfeld-Rechnung (1)
- Krampfader (1)
- Krankenhausmangement (1)
- Krankenversicherung (1)
- Kratom (1)
- Kreuzbandriss (1)
- Körperfett (1)
- Kühlwasser (1)
- Künstliche Lunge (1)
- LFA (1)
- LITT (1)
- Labormedizin (1)
- Lactobacillus brevis (1)
- Lactobacillus plantarum (1)
- Lactobacillus rossiae (1)
- Lactose (1)
- Langzeit-NMR (1)
- Laserablation (1)
- Lasertherapie (1)
- Late-onset-sepsis (1)
- Lebensmittel (1)
- Leberfettgehalt (1)
- Leberkrebs (1)
- Lenticule extraction (1)
- Leukozyt (1)
- Leukozyten-Endothel-Interkation (1)
- Leukozytenadhärenz (1)
- Leukozytenadhäsion (1)
- Leukämie (1)
- Levocarnitin (1)
- Ligand (1)
- Ligation-mediated PCR (1)
- Light (1)
- Linezolid (1)
- Lipide (1)
- Lippen-Kiefer-Gaumen-Spalten (1)
- Lippen-Kiefer-Gaumenspalte (1)
- Lokalanästhesie (1)
- Luftwaffenhelfer (1)
- Lung cancer (1)
- Lunge (1)
- Lungenembolie (1)
- Lungenentzündung (1)
- Lungenmetastase (1)
- Lungentumor (1)
- Lymph nodes (1)
- Lymphknoten (1)
- Lymphoblastic leukaemia (1)
- Lymphoplasmacytic sclerosing pancreatitis (1)
- Längsschnittuntersuchung (1)
- Löffler (1)
- MATLAB (1)
- MKG-Chirurgie (1)
- MKS-Virus (1)
- MNC (1)
- MRI (1)
- MRP4 (1)
- MRP5 (1)
- MRT (1)
- MSCEIT (1)
- Madagascar (1)
- Madagaskar (1)
- Magnet Force System (1)
- Magnetic Drug Targeting (1)
- Magnetic Resonance Imaging (1)
- Magnetisches Drug Targeting (1)
- Makak (1)
- Makrolidantibiotikum (1)
- Makrophage (1)
- Makrophagen (1)
- Management (1)
- Mangan (1)
- Markervakzine (1)
- Massenspektrometrie (1)
- Massenspektromie (1)
- Maul- und Klauenseuche (1)
- Mausmodell (1)
- Maxillary sinus (1)
- Mecklenburg-Vorpommern (1)
- Medihoney (1)
- Medizin (1)
- Medizingeschichte <Fach> (1)
- Medizinisches Labor (1)
- Mehrdimensionale Chromatographie (1)
- Melioidose (1)
- Membranfilter (1)
- Membranproteine (1)
- Meta-Analyse (1)
- Meta-analysis (1)
- Metabolische Azidose (1)
- Metabolisches Syndrom (1)
- Metacyclophane (1)
- Metallcluster (1)
- Metallkeramik (1)
- Metallkomplexe (1)
- Methodism (1)
- Methodismus (1)
- Mikrozirkulation (1)
- Milchzahn (1)
- Mimik (1)
- Minderheitenpolitik (1)
- Miniaturschwein (1)
- Mission to Jews (1)
- Mitragyna (1)
- Mitragynin (1)
- Mittlere Elbe (1)
- Modell (1)
- Moden (1)
- Molekulardynamik (1)
- Molekulare Virologie (1)
- Molke (1)
- Molybdän (1)
- Monooxygenase (1)
- Morbidität (1)
- Morphin (1)
- Morphogenese (1)
- Motivation (1)
- Mouse cell lines (1)
- Mouse model (1)
- Mucositis (1)
- Mundpflegemittel (1)
- Muskel (1)
- Mutationen (1)
- Muttermilch (1)
- Möwen (1)
- NEO-FFI (1)
- NMDA-Antagonist (1)
- NMDA-Rezeptor (1)
- NMR-Tomographie (1)
- NO (1)
- NOD2 (1)
- Nachbehandlung (1)
- Nachhaltige Entwicklung (1)
- Nachsorge (1)
- Nadelbaum (1)
- Narkose (1)
- Narkosesanierung (1)
- Nasenkapsel (1)
- Nasennebenhöhlen (1)
- Nasenseptum (1)
- Nationalpark (1)
- Nationalpark Gesäuse (1)
- Nationalpark Hohe Tauern (1)
- Naturschutz (1)
- Nebenerkrankungen (1)
- Network (1)
- Neugeborenensepsis (1)
- Neuroanatomie (1)
- Neuroimmunologie (1)
- Neutronenbeugung (1)
- Newcastle Disease Virus (1)
- Nicht-Parenchymzellen (1)
- Nicht-kleinzelliges Bronchialkarzinom (1)
- Nickel (1)
- Nickel catalysts (1)
- Nickelkatalysator (1)
- Nicotinamid N-Methyltransferase (1)
- Niere (1)
- Noradrenalin (1)
- Nordsee <Süd> (1)
- Northesstern Iibetan Plateau (1)
- Nuckelflaschenkaries (1)
- Nucleotidanaloga (1)
- Nukelfläschchenkaries (1)
- Numerische Mathematik (1)
- Nutritional risk factors (1)
- OATPB (1)
- Obstruktive Ventilationsstörung (1)
- Oligomerisation (1)
- Oligonukleotid Konjugate (1)
- Operation (1)
- Optimale Steuerung (1)
- Organische Synthese (1)
- Orofazial (1)
- Orthotopic murine model (1)
- Osteoconduction (1)
- Osteokonduktion (1)
- Osteosynthese (1)
- Otto Waldmann (1)
- Oxygen supply (1)
- P-Arylation (1)
- PB2 (1)
- PDT (1)
- PF4/Polyanionen –ELISA (1)
- PVP-Iod (1)
- Panc02 (1)
- Pancreatic surgery, complications (1)
- Pathogenität (1)
- Patient (1)
- Patientenakten (1)
- Patientengesteuerte Analgesie (1)
- Paul-Falle (1)
- Perfusion (1)
- Perfusionsänderung (1)
- Periimplantatfraktur (1)
- Periimplantatfraktur5 (1)
- Periphere arterielle Verschlusskrankheit (1)
- Perkutane transluminale Angioplastie (1)
- Pestivirus (1)
- Pflegeperson (1)
- Pharmakokinetik (1)
- Phosphaproline (1)
- Phosphaprolines (1)
- Phosphino amino acids (1)
- Phosphinoaminosäuren (1)
- Phosphinoaniline (1)
- Phospholamban (1)
- Phosphonium glycolates (1)
- Phosphoniumglykolate (1)
- Phosphoniumsalze (1)
- Phosphor-31-NMR-Spektroskopie (1)
- Phosphorylierung (1)
- Phosphotransferasesystem (1)
- Photodynamische Therapie (1)
- Phylogenie (1)
- Phytochemicals (1)
- Pilonbruch (1)
- Plasma (1)
- Plasmaextravasation (1)
- Plasmawelle (1)
- Plastische Chirurgie (1)
- Platin (1)
- Plazenta (1)
- Plesiocystis pacifica (1)
- Plättchenfaktor 4 (1)
- Plättchenfaktor 4 var1 (1)
- Polihexanide (1)
- Polyelektrolyt (1)
- Polyerase-Komplex (1)
- Populationsgenetik (1)
- Porcine corneal lenticules (1)
- Position Specific Scoring Matrix (1)
- Postimees (1)
- Postoperative immune suppression (1)
- Posttraumatisches Stresssyndrom (1)
- Potenzialhyperfläche (1)
- Povidon-Iod (1)
- PrV (1)
- Prediction (1)
- Premillennialism (1)
- Primates (1)
- Primärstabilität (1)
- Primärstabilität4 (1)
- Procalcitonin (1)
- Professionalisierung der Pflege (1)
- Prognosemodell (1)
- Proteasom (1)
- Protein (1)
- Proteinkinase B (1)
- Proteomics (1)
- Proteomik (1)
- Prämillenniarismus (1)
- Prävalenz (1)
- Prüfkörpertest (1)
- Pseudarthrose (1)
- Psychiatrie (1)
- Public Hospital Management (1)
- Pufferzone (1)
- Pulmonale Hypertonie (1)
- QM/MM (1)
- Qualifikation (1)
- Qualitative Empirsiche Sozialforschung (1)
- Quality of Management (1)
- Qualitätssicherung (1)
- Quantenchemie (1)
- Quantification (1)
- Quantifizierung (1)
- Quergestreifte Muskulatur (1)
- RAS (1)
- RKI-Richtlinie (1)
- RNS-Interferenz (1)
- Radikuläres Syndrom (1)
- Radioiodtherapie (1)
- Radiologie (1)
- Raucherentwöhnung (1)
- Raumluft (1)
- Raumordnung (1)
- Reaktionsdynamik (1)
- Reaktionsmechanismus (1)
- Reaktive Sauerstoffspezies (1)
- Recent warming (1)
- Regionalentwicklung (1)
- Regulatorischer T-Lymphozyt (1)
- Rekonstruktion (1)
- Remission (1)
- Reporterenzyme (1)
- Reporterenzymes (1)
- Reserpin (1)
- Resistenz (1)
- Resorption (1)
- Retention (1)
- Retentionsmechanismen (1)
- Retikulozyt (1)
- Retikulozytenhämoglobin (1)
- Retikulozytenzählung (1)
- Retropatellarerstatz (1)
- Rhesusaffe (1)
- Rhodococcus equi (1)
- Riems (1)
- Riems / Friedrich-Loeffler-Institut (1)
- Rifampicin (1)
- RiliBÄK (1)
- Risikogeburt (1)
- Ritual deformations (1)
- Rituelle Deformierungen (1)
- Rituximab (1)
- Rossendorf (1)
- Rubeosis iridis (1)
- Russian speakers (1)
- Russischsprachige (1)
- SERCA (1)
- SF-36 Health survey (1)
- SHIP (1)
- SNP (1)
- SNiP (1)
- SOC (1)
- SSA (1)
- STIM1 (1)
- Saccharomyces cerevisiae (1)
- Sae (1)
- Satellitenbildauswertung (1)
- Schaalsee (1)
- Schalteffekte (1)
- Schenkelhalsfraktur (1)
- Schienbein (1)
- Schilddrüsenfunktionsst (1)
- Schilddrüsenfunktionsstörung (1)
- Schilddrüsenhormone (1)
- Schilddrüsenkrankheit (1)
- Schimmelpilze (1)
- Schimmelpilzschaden (1)
- Schlaganfall (1)
- Schmalkiefer (1)
- Schmerz (1)
- Schulbesuch (1)
- Schutzgebietseffektivität (1)
- Schutzgebietsmanagement (1)
- Schwangerschaft (1)
- Schwarze Tollkirsche (1)
- Schweineleberesterase (1)
- Schwerelosigkeit (1)
- Schönheitsideal (1)
- Score (1)
- Sedimentation (1)
- Sekundärglaukom (1)
- Selbsthilfe (1)
- Selbstorganisation (1)
- Selbstähnlichkeit (1)
- Selektivität (1)
- Sentinel Lymphknoten (1)
- Sieben <Verfahrenstechnik> (1)
- Signaltransduktion (1)
- Silber (1)
- Silicosis (1)
- Silikose (1)
- Silver wound dressing (1)
- Skelettmuskulatur (1)
- Skin barrier (1)
- Social Health Insurance (1)
- Somatotropin (1)
- Soziale Unterstützung (1)
- Sozialistische Einheitspartei Deutschlands (1)
- Spannungskopfschmerz (1)
- Spektroskopie (1)
- Spezifität (1)
- Spontan hypertensive Ratten (1)
- Sprachpolitik (1)
- Staatsbürgerschaft (1)
- Stabilitätsuntersuchungen (1)
- Statistische Qualitätskontrolle (1)
- Stent (1)
- Stereoskopie (1)
- Stoffwechsel (1)
- Stratum corneum (1)
- Streptococcus pneumoniae (1)
- Stress (1)
- Struktur (1)
- Studie (1)
- Study of Health in Pomerania. Tension-type headache. depression. populations-based study. (1)
- Study of health in pomerania (1)
- Subsaharisches Afrika (1)
- Suction blister (1)
- Suction blister technique (1)
- Sukzession (1)
- Superantigen (1)
- Surgery (1)
- Surgical strategy (1)
- Surgically induced immune dysfunction (1)
- Sympathikus (1)
- Syphilis (1)
- Syria (1)
- Syrien (1)
- Säure-Base-Gleichgewicht (1)
- T2*-Effekt (1)
- TAS-20 (1)
- TCI <Persönlichkeitstest> (1)
- TMD (1)
- TNF (1)
- TRP Kanäle (1)
- TRP channels (1)
- TRPV4 (1)
- TRPV4-Knock out (1)
- Tabak (1)
- Tabakabstinenz (1)
- Targeted drug delivery (1)
- Taurocholate (1)
- Temperaturmessung (1)
- Testosteron (1)
- Testosteronreductase <Testosteron-5-alpha-Reductase> (1)
- Tetracyclin (1)
- Tetracyclinrepressor (1)
- Textanalyse (1)
- Textlinguistik (1)
- The Study of Health in Pomerania (1)
- Therapie (1)
- Thermodynamik (1)
- Thomasplot (1)
- Thrombose (1)
- Thyreostatika (1)
- Thyreotropin (1)
- Tigecyclin (1)
- Tinnitus (1)
- Titan3 (1)
- Total testosterone (1)
- Totale Zahnprothese (1)
- Totalprothese (1)
- Toxicity (1)
- Trans-Theoretisches Modell der Verhaltensänderung (1)
- Transcription Factor Binding Site (1)
- Transcriptomics (1)
- Transepidermal water loss (1)
- Transepidermaler Wasserverlust (1)
- Transferrinrezeptor (1)
- Transkriptionsfaktorbindestellen (1)
- Translokation (1)
- Transplantat-Wirt-Reaktion (1)
- Transplantrelated morbidity (1)
- Transport (1)
- Transportstress (1)
- Transtheoretisches Modell (1)
- Tranylcypromin (1)
- Tripper (1)
- Tuberkelbakterium (1)
- Tumor-Nekrose-Faktor (1)
- Tumorkachexie (1)
- Tumormarker (1)
- Tumormodell (1)
- Tumornekrosefaktor-Alpha (1)
- Tumour necrosis factor-alpha (1)
- UV-Schutz (1)
- UVB (1)
- Ultraviolett B (1)
- Umfrage (1)
- Umkehrphasen-HPLC (1)
- Unfall (1)
- Universalism (1)
- Urinary iodine excretion (1)
- Urtinktur (1)
- Venenastverschluss (1)
- Venlafaxin (1)
- Ventil (1)
- Ventilation (1)
- Ventrales-Striatum (1)
- Venturi (1)
- Verb (1)
- Verbraucherzufriedenheit (1)
- Verhaltensmodifikation (1)
- Verlaufsbeobachtung (1)
- Versorgungssituation (1)
- Very low birthweight infants (1)
- Veränderungsmotivation (1)
- Virus-Eintritt (1)
- Virusdiarrhoe-Mucosal-Disease-Virus (1)
- Visite (1)
- Visitengespräch (1)
- Visualization (1)
- Vogelgrippe (1)
- WOMAC (1)
- Wachstum Gesichtsschädel (1)
- Wachstumshormonsubstitution (1)
- Wahrnehmung von Waldwerten (1)
- Was (1)
- Wasseraufbereitung (1)
- Wasserleitung (1)
- Water-filtered infrared-A radiation (1)
- Watt (1)
- Weltkrieg <1939-1945> (1)
- Whistlerwelle (1)
- Wiederkunft Christi (1)
- Windwurf (1)
- Wissen (1)
- Wissenschaftspolitik (1)
- Wound (1)
- Wound at risk of infection (1)
- Wound at risk score (W.A.R. score) (1)
- Wound colonization (1)
- Wound healing (1)
- Wound secretion (1)
- Wundverband (1)
- Zahn (1)
- Zahnarzt (1)
- Zahnarztpraxis (1)
- Zahnbewegung (1)
- Zahnmedizin (1)
- Zahnokklusion (1)
- Zahnschmerz (1)
- Zahntrauma (1)
- Zahnverletzung (1)
- Zahnärztlicher Kinderpass (1)
- Zellkultur (1)
- Zellzyklus (1)
- Zentralvenenverschluss (1)
- Zwangsarbeiter (1)
- [ (1)
- absorption (1)
- actinic (1)
- acute stress (1)
- acylhydrazones (1)
- adaptation (1)
- adaptives Immunsystem (1)
- adenylylcyclase (1)
- ageing (1)
- aktinische (1)
- akute Graft-versus-Host Erkrankung (1)
- akuter Stress (1)
- alcohol (1)
- algicolous fungi (1)
- alkohol-attributable Morbidität (1)
- ambulatory surgery (1)
- anatomy (1)
- antibacterial (1)
- antibiotic resistance (1)
- antiglobulin crossmatch (1)
- antimicrobial activity (1)
- antimikrobielle Aktivität (1)
- antiseptics (1)
- antiterminator protein (1)
- anxiety (1)
- apoptosis (1)
- artifact (1)
- biomechanisch1 (1)
- biomechanische Untersuchung (1)
- biosphere reserve (1)
- biosphere reserves (1)
- bone mineralization (1)
- bone substitute material (1)
- boreal peatlands (1)
- bowel injury (1)
- bronchoalveoläre Lavage (1)
- buffer zone (1)
- c-Met (1)
- cGMP (1)
- calcium homeostasis (1)
- cancer cachexia (1)
- capability approach (1)
- capillary leakage (1)
- carbon fluxes (1)
- cardiovascular health (1)
- cataract (1)
- cephalogram (1)
- cerclages1 (1)
- cfu (1)
- chemical shift (1)
- chemische Verschiebung (1)
- chondroitin sulfate (1)
- chronisch neuropathischer Schmerz (1)
- chronische Graft-versus-Host Erkrankung (1)
- citizenship (1)
- clarithromycin (1)
- cleft (1)
- complex plasma (1)
- computed tomography (1)
- cone beam tomography (1)
- coniferous trees (1)
- conventional tube test (1)
- cooling water (1)
- craniomandibular dysfunction (1)
- craniomandibuläre Dysfunktion (1)
- culture (1)
- cylindrical wave (1)
- cytotoxic (1)
- cytotoxic activity (1)
- degradation (1)
- denture (1)
- der pflegende Angehörige (1)
- diagnostic imaging (1)
- diapa (1)
- discourse analysis (1)
- distal forearm fracture (1)
- distal tibia (1)
- distale Tibiafraktur (1)
- distale Unterarmfraktur (1)
- district hospital (1)
- doctor-patient interaction (1)
- duwl (1)
- eNOS (1)
- early childhood caries (1)
- ecosystem services (1)
- edentulos (1)
- electron microscopic morphology (1)
- elementary school (1)
- enoxaparin (1)
- essentielles Tegumentprotein pUL36 (1)
- ethiopia (1)
- evolution (1)
- exposure (1)
- external fixation (1)
- extraocular muscles (1)
- facial (1)
- fat (1)
- fatigue syndrome (1)
- fdtd (1)
- feasibility (1)
- femoral neck fracture (1)
- fett (1)
- fettlappen (1)
- fettrekonstruktion (1)
- filtration (1)
- finite difference in time domain (1)
- forest value perception (1)
- fortifier (1)
- fractal (1)
- full-wave (1)
- fungicide (1)
- funktionelle Kapillardichte (1)
- gamma nail3 (1)
- gebärfähiges Alter (1)
- gene expression (1)
- gesundheitssystem (1)
- glutathione peroxidase (1)
- growth hormone deficiency (1)
- growth hormone replacement therapy (1)
- health care situation (1)
- health care system (1)
- heavy user (1)
- hemagglutinin (1)
- hepatocarcinogenesis (1)
- herpesvirus (1)
- heterofermentativ (1)
- hexavalent vaccine (1)
- hexavalenter Impfstoff (1)
- high utiliser (1)
- high-energy (1)
- hip fract (1)
- histidine (1)
- homofermentativ (1)
- house dust (1)
- humane embryonale Nierenzellen (1)
- hylobatidae (1)
- immunomodulation (1)
- in vitro an in vivo (1)
- indirict antiglobulin test (1)
- indoloquinoline (1)
- indoor air (1)
- induzierbare Stickstoffsynthase (1)
- inhibition (1)
- inhomogeneous plasma (1)
- inhomogenes plasma (1)
- insulininduzierte Hepatokarzinogenese (1)
- integration policy (1)
- internal fixation (1)
- intracellular (1)
- intracellular transport (1)
- intrazellulär (1)
- intrazellulärer Transport (1)
- iodine (1)
- ipf-fd3d (1)
- italienischer Militärinternierte (1)
- kapilläres Leck (1)
- kardiovaskuläre Gesundheit (1)
- keratinocytes (1)
- keratoses (1)
- klarzelliges Nierenzellkarzinom (1)
- krankenhaus (1)
- kratom (1)
- language policy (1)
- large tegument protein pUL36 (1)
- light (1)
- local anesthesia (1)
- lung (1)
- lung ventilation (1)
- mRNA-Stabilität (1)
- mRNA-stability (1)
- magnetische kieferorthopädische Geräte (1)
- manufacturing technology (1)
- marinen Pilze (1)
- marker vaccines (1)
- mass spectrometry (1)
- mdx Maus (1)
- membrane protein (1)
- mesenterial microcirculation (1)
- mesenteric injury (1)
- metastases (1)
- microcolumn technology (1)
- mikrobiologische Wasseranalyse (1)
- mikrozytär (1)
- minority policy (1)
- mitragynin (1)
- monooxygenase (1)
- morphology (1)
- mould damage (1)
- moulds (1)
- mouse (1)
- narrow upper dental arch (1)
- nasal capsule (1)
- nasal septum (1)
- nasale Besiedlung (1)
- natural products (1)
- neighbor map (1)
- neue Virulenzfaktoren (1)
- new virulence factors (1)
- newspaper (1)
- non-parenchymal cells (1)
- normozytär (1)
- nuclear power (1)
- nuclear research (1)
- nucleotide analogues (1)
- numerical simulation (1)
- numerische simulation (1)
- nursing education research (1)
- nutrients (1)
- oligonucleotide conjugate (1)
- oral health (1)
- orale Mundgesundheit (1)
- organic (1)
- orofacial pain (1)
- orthodontics (1)
- pUL35 (1)
- pUL37 (1)
- pain (1)
- paranasal sinuses (1)
- patella prothesis (1)
- patient-doctor communication (1)
- pediatric dentistry (1)
- pediatric surgery (1)
- perfusion (1)
- periodontitis (1)
- perioperative Morbidität (1)
- perioperative Mortalität (1)
- perioperative morbidity (1)
- perioperative mortality (1)
- peritonitis (1)
- pff (1)
- pflegerische Qualifikationsforschung (1)
- pharmaceutical care (1)
- pharmaceutical service (1)
- pharmazeutische Betreuung (1)
- pharmazeutischer Service (1)
- phosphorylation (1)
- phosphotransferase system (1)
- photodynamic (1)
- photodynamische (1)
- phylogeny (1)
- phytoplankton (1)
- pilon fracture (1)
- placenta (1)
- platelet factor 4 heparin antibodies (1)
- point mutation (1)
- polymerase complex (1)
- postnatales Wachstum (1)
- premature (1)
- preterm infants (1)
- prevalence of caries (1)
- prevention (1)
- primary health care (1)
- primary stability4 (1)
- primäre Pneumatisation (1)
- prosthesis (1)
- proteced area management effectiveness (1)
- protein interaction (1)
- protein kinase (1)
- proteolysis (1)
- psychiatric (1)
- pulmonary disease (1)
- quantitative suspensiontest (1)
- quantitativer Suspensionstest (1)
- re-establishment of macrophages (1)
- redox-sensitive trace metals (1)
- regulatory T cells (1)
- rekonstruktiv (1)
- relaxation effects (1)
- reserpine (1)
- retinal (1)
- reverse Genetik (1)
- reverse genetics (1)
- reward (1)
- roller (1)
- rounds (1)
- rvo (1)
- sTfR (1)
- satisfaction (1)
- sea gulls (1)
- secondary dislocation (1)
- sediment (1)
- sekundäre Dislokation (1)
- self-similarity (1)
- sepsis (1)
- settled dust (1)
- shared decision-making (1)
- sieving (1)
- sigB (1)
- signal transduction (1)
- silver wound dressing (1)
- sinus maxillaris (1)
- smoking (1)
- social-ecologic systems (1)
- social-ecological system (1)
- somatotrope Insuffizienz (1)
- sozial-ökologische Systeme (1)
- soziale Unterstützung (1)
- spine diseases (1)
- stability studies (1)
- stationäre Psychotherapie (1)
- stereoscopy (1)
- sticker (1)
- study of health in pomerania (1)
- survival (1)
- sympathetic nervous system (1)
- sympathische Denervierung (1)
- teeth mutilation (1)
- temporomandibular joint (1)
- tetracycline (1)
- therapy (1)
- thyroid (1)
- tibial fracture (1)
- tibial plafond fracture (1)
- titanium2 (1)
- tooth deformation (1)
- tooth movement (1)
- transport (1)
- transportation stress (1)
- trauma (1)
- tumorassoziierte Enzymalteration (1)
- ultrasound-guided radiofrequency (1)
- unfraktioniertes Heparin (1)
- vaccination acceptance (1)
- vaccination behaviour (1)
- vaccination rate (1)
- venous (1)
- ventral-striatum (1)
- venturi apparatus (1)
- viral replication (1)
- virion morphogenesis (1)
- virus entry (1)
- von Hippel-Lindau-Syndrom (1)
- ward round (1)
- water column (1)
- weight gain (1)
- whistler wave (1)
- zahnlos (1)
- zweidimensionale Westernblots (1)
- zylindrische Welle (1)
- zytotoxische Aktivität (1)
- Äthiopien (1)
- Ökosystemdienstleistung (1)
- Ökosystemdienstleistungen (1)
- Überleben (1)
Institute
- Institut für Hygiene und Umweltmedizin (14)
- Abteilung für Mikrobiologie und Molekularbiologie (10)
- Institut für Community Medicine (10)
- Poliklinik für Kieferorthopädie, Präventive Zahnmedizin und Kinderzahnheilkunde (10)
- Institut für Biochemie (8)
- Institut für Pharmazie (8)
- Klinik für Anästhesiologie und Intensivmedizin (8)
- Institut für Diagnostische Radiologie und Neuroradiologie (7)
- Institut für Anatomie und Zellbiologie (6)
- Institut für Physik (6)
Publisher
- S. Karger AG (19)
- IOP Publishing (1)
In vivo Imaging of Bile Accumulation and Biliary Infarction after Common Bile Duct Ligation in Rats
(2011)
Obstructive cholestasis is caused by mechanical constriction or occlusion leading to reduced bile flow. Serious complications such as jaundice and even death may follow. Little is known about the initial phase of cholestasis and its consequences for the hepatic microarchitecture. This in vivo study aimed to characterize the nature and kinetics of developing obstructive cholestasis and focused on areas with biliary stasis and infarction by visualizing the autofluorescence of bile acids using intravital microscopy of the liver over a period of 30 h after bile duct ligation in rats. The innovation resided in performing fluorescence microscopy without applying fluorescent dyes. In animals subjected to obstructive cholestasis, the most significant changes observed in vivo were the concomitant appearance of (1) areas with bile accumulation increasing in size (6 h: 0.163 ± 0.043, 18 h: 0.180 ± 0.086, 30 h: 0.483 ± 0.176 mm<sup>2</sup>/field) and (2) areas with biliary infarction (6 h: 0.011 ± 0.006, 18 h: 0.010 ± 0.004, 30 h: 0.010 ± 0.050 mm<sup>2</sup>/field) as well as (3) a relation between the formation of hepatic lesions and enzyme activity in serum. The sequential in vivo analysis presented herein is a new method for the in vivo visualization of the very early changes in the hepatic parenchyma caused by obstructive cholestasis.
Ernst Ferdinand Ströter (1846-1922) stammt aus einem reformierten Elternhaus in Barmen. Während seines Theologiestudiums wurde er nachhaltig geprägt von Johann Tobias Beck (1804-1878). Ströter übernahm unter anderem dessen Hermeneutik einer ausgeprägten Schriftbezogenheit, den Ansatz einer wachsenden Offenbarung innerhalb der Schrift und eine ausdifferenzierte zukünftig-heilsgeschichtliche Eschatologie prämillenniaristischer Lesart. Als Hauslehrer einer amerikanischen Familie in Paris konvertierte Ströter zum Methodismus und wanderte 1869 in die USA aus. Dort wirkte er zunächst als Hilfsprediger an der Ostküste unter dem Dach des deutschsprachigen bischöflichen Methodismus und anschließend – mittlerweile verheiratet – als Pionierprediger in Texas. Neben seinen pastoralen Tätigkeiten intendierte er dort die Vereinigung der Bischöflich-methodistischen Kirche mit der Bischöflich-methodistischen Kirche des Südens, gründete eine Schule und unterstützte literarisch die damalige Temperenzbewegung. 1879 wurde er mit dem dispensationalistischen Prämillenniarismus John Nelson Darbys (1800-1882) bekannt. Von Darby übernahm Ströter – in Ergänzung zu Becks Einflüssen – besonders das kirchenkritische Gemeindeverständnis, eine ausgeprägte Erwartung der Wiederkunft Christi, die Entrückungsvorstellung der Gemeinde und die theologisch-heilsgeschichtliche Unterscheidung von Gemeinde und Israel. Allerdings schloss sich Ströter nicht – ebenso wenig wie die dispensationalistisch-prämillenniaristische Bewegung seiner Zeit im Ganzen – der Brüderbewegung und einer von Darby geforderten Lösung von der eigenen Denomination an. Innerhalb des deutschsprachigen bischöflichen Methodismus versuchte Ströter, den dispensationalistischen Prämillenniarismus mit seinen gemeindetheologischen Ableitungen bekanntzumachen. Doch wurden seine Lehransichten dort 1881 verurteilt, was Ströter zur inneren Entfremdung von seiner Kirche führte. Er wirkte noch bis 1884 als Prediger in Minnesota, ging dann als theologischer Lehrer an eine methodistische Hochschule (1884-1890) und schließlich als Professor für Latein an die Universität von Denver (1890-1894). Außerhalb des Methodismus propagierte Ströter weiterhin den dispensationalistischen Prämillenniarismus literarisch und durch Vorträge, etwa auf der Niagara Bible Conference. Anschließend gab Ströter jede Form von Festanstellung auf und wirkte 1894-1899 als freier Prediger gemeinsam mit Clemens Arno Gäbelein unter Juden in New York. Ströters und Gäbeleins Hope of Israel Mission vertrat den Ansatz, Judenchristen nicht aus ihrer national-jüdischen Existenz zu lösen, sondern in Toraobservanz zu belassen. Nach einer ersten Europareise 1896 im Auftrag der Hope of Israel Mission kehrte Ströter 1897 als Judenmissionar und freier Prediger nach Europa zurück. Hier unternahm er zahlreiche Vortragsreisen nach Osteuropa, insbesondere nach Russland, und gründete eine eigene Gesellschaft, die die Ansiedlung von Judenchristen im damaligen Palästina unterstützte. Leidenschaftlich unterstützte er auch den politischen Zionismus. Daneben wirkte er als vielgefragter Redner auf zahlreichen Plattformen der damaligen neueren deutschen Erweckungsbewegung, besonders auf den Blankenburger Allianz-, den Tersteegensruh- und den Harzkonferenzen, in Gemeinschaften und in freien Gemeinden. Auch in Europa verfocht Ströter den Prämillenniarismus sowie sein Gemeindeverständnis, wonach die Gemeinde keine institutionelle Größe, sondern von Gott erwählt sei, nach ihrer Entrückung an Christi zukünftigem Heilsschaffen mitzuwirken. 1908 wurde seine Theologie von der Blankenburger Allianz und der Gnadauer Gemeinschaftsbewegung abgelehnt. Ströter hatte mittlerweile seine eigene reformierte Prägung transformiert und in Verknüpfung mit Prämillenniarismus, Israeltheologie und Gemeindeverständnis zu einer Allversöhnungslehre weiterentwickelt. Diese vertrat er durch weitere zahlreiche Vorträge, mit seiner Zeitschrift Das Prophetische Wort (seit 1907) und durch weitere Veröffentlichungen. Auch Ströters Allversöhnungslehre wurde im Raum der neueren deutschen Erweckungsbewegung in einem literarisch geführten Streit fast überwiegend abgewiesen und vertiefte seine theologische Isolierung. 1912 siedelte Ströter in die Schweiz über – sein Schwiegersohn John Louis Nuelsen (1867-1946) – war dort methodistischer Bischof geworden. Der Erste Weltkrieg unterband die Reisen nach Russland und beeinträchtigte die Vortragstätigkeit in Deutschland. Nach dem Krieg und bis zu seinem Tod in Zürich versuchte Ströter noch einmal verstärkt in Deutschland theologisch Fuß zu fassen, fand mit seinen Lehransichten aber nur bei Einzelpersonen und in kleineren Zirkeln Gehör. Ströter darf als markantester Vertreter des dispensationalistischen Prämillenniarismus innerhalb des deutschsprachigen Methodismus in den USA und innerhalb der neueren deutschen Erweckungsbewegung gelten. Sein Ziel, diesem eine größere Bekanntheit zu verschaffen, hat Ströter jedoch nicht erreicht. Heute lebt Ströters theologisch-heilsgeschichtliches Erbe, dessen theologische Spitze und Summe sich in der Allversöhnungslehre findet, bei kleinen, in der Regel nicht institutionalisierten Gruppierungen fort. Zu würdigen bleiben Ströters Rolle innerhalb des deutschsprachigen Methodismus besonders in den USA und innerhalb der neueren deutschen Erweckungsbewegung, sein Beitrag zur Geschichte der Judenmission, manche seiner theologischen Impulse wie beispielsweise seine aus seiner Israeltheologie resultierende Erwählungslehre, die Einfluss auf Karl Barths (1886-1968) Erwählungslehre genommen hat, sowie seine wache Zeitzeugenschaft, die ihn bereits 1921 vor dem – von ihm so genannten – "Hakenkreuz-Antisemitismus" warnen ließ.
Purpose: To determine the surface characteristics of porcine corneal lenticules after Femtosecond Lenticule Extraction. Methods: The Carl Zeiss Meditec AG VisuMax® femtosecond laser system was used to create refractive corneal lenticules on 10 freshly isolated porcine eyes. The surface regularity on the corneal lenticules recovered was evaluated by assessing scanning electron microscopy images using an established scoring system. Results: All specimens yielded comparable score results of 5–7 points (SD = 0.59) per lenticule (score range minimum 4 to maximum 11 points). Surface irregularities were caused by tissue bridges, cavitation bubbles or scratches. Conclusion: The Femtosecond Lenticule Extraction procedure is capable of creating corneal lenticules of predictable surface quality. However, future studies should focus on the optimization of laser parameters as well as surgical technique to improve the regularity of the corneal stromal bed.
For surgery in congenital hyperinsulinism (CHI), a distinct surgical strategy and technique is required for focal, diffuse and atypical CHI. In focal CHI, a confined, localized and parenchyma-sparing resection which is guided by the PET-CT is always indicated in order to cure the patient. In diffuse CHI, however, the results of surgical therapy are unpredictable and cure is an exception. Therefore, a strong tendency exists nowadays that medical therapy should be preferred in diffuse CHI. In atypical CHI the situation is more complex: if the focal lesion or the segmental mosaic are not too extensive, cure by resection should be possible. But care must be taken in atypical cases not to resect too much of the gland in order not to induce diabetes.
Background: Therapyrelated mucositis is associated with considerable morbidity. This complication following allogeneic stem cell therapy (alloSCT) is less severe after reduced intense conditioning (RIC); however, even here it may be serious. Methods: 52 patients (male: n = 35 (67%), female: n = 17 (33%)) at a median age of 62 years (35–73 years) underwent alloSCT after RIC. Conditioning was either total body irradiation (TBI)<sub>2Gy</sub>/±fludarabine (n = 33, 63.5%) or chemotherapy based. Graftversushost disease (GvHD) prophylaxis was carried out with cyclosporine A ± mycophenolate mofetil (MMF). 45 patients (87%) received shortcourse methotrexate (MTX). Mucositis was graded according to the Bearman and the World Health Organisation (WHO) scale. A variety of parameters were correlated with mucositis. Results: The Bearman and WHO scales showed excellent correlation. Mucositis was significantly more severe after chemotherapybased conditioning compared to conditioning with TBI<sub>2Gy</sub>/±fludarabine (p < 0.002) as well as in cases with an increase in creatinine levels above the upper normal value (UNV) on day +1 after SCT (p < 0.05). Furthermore, the severity correlated with time to engraftment of leucocytes (correlation coefficient (cc) = 0.26, p < 0.02) and thrombocytes (cc = 0.38, p < 0.001). Conclusions: The conditioning regimen and increased creatinine levels at day +1 were identified as factors predicting the severity of mucositis after RICSCT. Creatinine levels on day +1 after SCT may help identify patients at risk for severe mucositis in the further course of transplantation.
Aim: The efficacy of antimicrobial compounds included in wound dressings has been determined using the quantitative suspension test according to EN 13727 before. However, as suspension tests are not an accurate reflection of the conditions under which wound antiseptics are used, it was investigated if a disc carrier test would yield results simulating practical conditions on wound surfaces. A silver-leaching foam wound dressing was used for evaluation of the disc carrier test method. Method: The disc carriers consisted of circular stainless-steel discs measuring 2 cm in diameter and 1.5 mm in thickness, complying with the requirements of EN 10088-2. Carriers were contaminated with Staphylococcus aureus, methicillin-resistant S. aureus or Pseudomonas aeruginosa, respectively, together with an artificial wound secretion and left to dry at room temperature for 30 min. The wound dressings being tested were placed on the discs for the length of the exposure time, and after neutralization by thioglycolate in phosphate-buffered saline the number of surviving test organisms was then counted. The logarithmic reduction factor was calculated from the difference between the initial inoculum and the number of recovered test organisms. Results: The disc carrier test allowed determination of an antimicrobial efficacy in a realistic setting. It also imposed more stringent requirements on efficacy over time than the quantitative suspension test. The silver foam wound dressing showed a time-dependent antimicrobial efficacy. After 24-hour application time, the reduction factors against S. aureus, P. aeruginosa and the methicillin-resistant S. aureus were 1.9 ± 0.15, 2.1 ± 0.14 and 3.1 ± 0.18, respectively. Conclusion: The disc carrier test was a useful method for testing the antimicrobial efficacy of a foam silver dressing. The antimicrobial dressing exhibited an antimicrobial effect after 3 h and achieved a reduction >2 log against the tested bacterial strains in the presence of a simulated wound secretion after 24 h.
The effect of water-filtered infrared-A radiation (wIRA) on normal skin flora was investigated by generating experimental wounds on the forearms of volunteers utilizing the suction blister technique. Over 7 days, recolonization was monitored parallel to wound healing. Four groups of treatment were compared: no therapy (A), dexpanthenol cream once daily (B), 20 min wIRA irradiation at 30 cm distance (C), and wIRA irradiation for 30 min once daily together with dexpanthenol cream once daily (D). All treatments strongly inhibited the recolonization of the wounds. Whereas dexpanthenol completely suppressed recolonization over the test period, recolonization after wIRA without (C) and in combination with dexpanthenol (D) was suppressed, but started on day 5 with considerably higher amounts after the combination treatment (D). Whereas the consequence without treatment (A) was an increasing amount of physiological skin flora including coagulase-negative staphylococci, all treatments (B–D) led to a reduction in physiological skin flora, including coagulase-negative staphylococci. In healthy volunteers, wIRA alone and in combination with dexpanthenol strongly inhibited bacterial recolonization with physiological skin flora after artificial wound setting using a suction-blister wound model. This could support the beneficial effects of wIRA in the promotion of wound healing.
The exact qualitative and quantitative analysis of wound healing processes is a decisive prerequisite for optimizing wound care and for therapy control. Transepidermal water loss (TEWL) measurements are considered to be the standard procedure for assessing the progress of epidermal wound healing. The damage to the stratum corneum correlates with an increased loss of water through the skin barrier. This method is highly susceptible to failure by environmental factors, in particular by temperature and moisture. This study was aimed at comparing TEWL measurements and in vivo laser scanning microscopy (LSM) for the characterization of the epidermal wound healing process. LSM is a high-resolution in vivo method permitting to analyze the kinetics and dynamics of wound healing at a cellular level. While the TEWL values for the individual volunteers showed a wide scattering, LSM permitted the wound healing process to be clearly characterized at the cellular level. However, a comparison between the two methods was very difficult, because the results provided by LSM were images and not numerical. Therefore, a scoring system was set up which evaluates the stages of wound healing. Thus, the healing process could be numerically described. This method is independent of any environmental factors. Providing morphologically qualitative and numerically quantitative analyses of the wound healing process and being far less vulnerable to failure, LSM is advantageous over TEWL.
Wound healing disorders frequently occur due to biofilm formation on wound surfaces requiring conscientious wound hygiene. Often, the application of conventional liquid antiseptics is not sufficient and sustainable as (1) the borders and the surrounding of chronic wounds frequently consist of sclerotic skin, impeding an effectual penetration of these products, and (2) the hair follicles representing the reservoir for bacterial recolonization of skin surfaces are not affected. Recently, it has been reported that tissue-tolerable plasma (TTP), which is used at a temperature range between 35 and 45°C, likewise has disinfecting properties. In the present study, the effectivity of TTP and a standard liquid antiseptic was compared in vitro on porcine skin. The results revealed that TTP was able to reduce the bacterial load by 94%, although the application of the liquid antiseptic remained superior as it reduced the bacteria by almost 99%. For in vivo application, however, TTP offers several advantages. On the one hand, TTP enables the treatment of sclerotic skin as well, and on the other hand, a sustainable disinfection can be realized as, obviously, also the follicular reservoir is affected by TTP.
Postoperative Immune Suppression in Visceral Surgery: Characterisation of an Intestinal Mouse Model
(2011)
Background: Postoperatively acquired immune dysfunction is associated with a higher mortality rate in case of septic complications. As details of this severe clinical problem are still unknown, animal models are essential to characterise the mechanisms involved. Methods: Mice were laparotomised and the small intestine was pressed smoothly in antegrade direction. For extension of trauma, the intestine was manipulated three times consecutively. Following this, the ex vivo cytokine release of splenocytes was determined. The degree of surgical trauma was analysed by detection of HMGB1 and IL-6 in serum and by neutrophil staining in the muscularis mucosae. Results: We adapted the previously described animal model of intestinal manipulation to provide a model of surgically induced immune dysfunction. Following intestinal manipulation, the mice showed elevated serum levels of HMGB1 and IL-6 and increased infiltration of granulocytes into the muscularis mucosae. Ex vivo cytokine release by splenocytes was suppressed in the postoperative period. The degree of suppression correlated with the extent of surgical trauma. Conclusions: In this study, we describe a surgically induced immune dysfunction animal model, in which a significant surgical trauma is followed by an immune dysfunction. This model may be ideal for the characterisation of the postoperative immune dysfunction syndrome.