Refine
Year of publication
- 2017 (1)
Document Type
- Doctoral Thesis (1)
Language
- English (1) (remove)
Has Fulltext
- yes (1)
Is part of the Bibliography
- no (1)
Keywords
- life cycle (1) (remove)
Institute
- Institut für Biometrie und Medizinische Informatik (1) (remove)
The intracellular life cycle of the human immunodeficiency virus (HIV) is modelled using ordinary differential equations (ODEs). Model parameters are obtained from the literature or fitted to experimental data using parameter estimation procedures. Key steps in the life cycle are inhibited singly and in combination to show the effects on viral replication. The results validate the success of highly active antiretroviral therapy (HAART), and in addition DNA nuclear import is identified as a novel influential therapeutic target.