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This article gives an initial overview of the explanatory power of established approaches in comparative political science of various lockdown strategies in connection with the COVID-19 pandemic in 35 democracies. In a macro-comparative statistical analysis of the first wave of the pandemic, I test partisan and veto player theories. I distinguish two phases of the first wave of the COVID-19 pandemic, which show distinct patterns of political impacts. In the first phase of implementing lockdown strategies, central governments were relatively uncontested and partisan theory has strong explanatory power. In the second phase of lifting lockdowns, party differences lose relevance, but veto players have a strong influence during this time. The analysis shows that political science theories are useful for analysing political processes not only under normal conditions but also in extreme social crises. Moreover, it provides deeper insights into the democratic decision-making process of advanced democracies in exceptional situations.