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Contribution of Human Thrombospondin-1 to the Pathogenesis of Gram-Positive Bacteria
- A successful colonization of different compartments of the human host requires multifactorial contacts between bacterial surface proteins and host factors. Extracellular matrix proteins and matricellular proteins such as thrombospondin-1 play a pivotal role as adhesive substrates to ensure a strong interaction with pathobionts like the Gram-positive Streptococcus pneumoniae and Staphylococcus aureus. The human glycoprotein thrombospondin-1 is a component of the extracellular matrix and is highly abundant in the bloodstream during bacteremia. Human platelets secrete thrombospondin-1, which is then acquired by invading pathogens to facilitate colonization and immune evasion. Gram-positive bacteria express a broad spectrum of surface-exposed proteins, some of which also recognize thrombospondin-1. This review highlights the importance of thrombospondin-1 as an adhesion substrate to facilitate colonization, and we summarize the variety of thrombospondin-1-binding proteins of S. pneumoniae and S. aureus.
Author: | Ulrike Binsker, Thomas P. Kohler, Prof. Dr. Sven HammerschmidtORCiD |
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URN: | urn:nbn:de:gbv:9-opus-38250 |
DOI: | https://doi.org/10.1159/000496033 |
ISSN: | 1662-811X |
ISSN: | 1662-8128 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/30814475 |
Parent Title (English): | Journal of Innate Immunity |
Publisher: | S. Karger AG |
Place of publication: | Basel |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2019/02/27 |
Release Date: | 2022/04/04 |
Tag: | Colonization; Dissemination; Human thrombospondin-1 |
GND Keyword: | - |
Volume: | 11 |
Issue: | 4 |
First Page: | 303 |
Last Page: | 315 |
Faculties: | Mathematisch-Naturwissenschaftliche Fakultät / Interfakultäres Institut für Genetik und Funktionelle Genomforschung (MNF) |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung |