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Cold Atmospheric Plasma in the Treatment of Osteosarcoma
- : Human osteosarcoma (OS) is the most common primary malignant bone tumor occurring most commonly in adolescents and young adults. Major improvements in disease-free survival have been achieved by implementing a combination therapy consisting of radical surgical resection of the tumor and systemic multi-agent chemotherapy. However, long-term survival remains poor, so novel targeted therapies to improve outcomes for patients with osteosarcoma remains an area of active research. This includes immunotherapy, photodynamic therapy, or treatment with nanoparticles. Cold atmospheric plasma (CAP), a highly reactive (partially) ionized physical state, has been shown to inherit a significant anticancer capacity, leading to a new field in medicine called “plasma oncology.” The current article summarizes the potential of CAP in the treatment of human OS and reviews the underlying molecular mode of action.
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| Author: | Denis Gümbel, Sander BekeschusORCiD, Nadine Gelbrich, Matthias Napp, Axel Ekkernkamp, Axel KramerORCiD, Matthias Stope |
|---|---|
| URN: | urn:nbn:de:gbv:9-opus-65173 |
| DOI: | https://doi.org/10.3390/ijms18092004 |
| ISSN: | 1422-0067 |
| Parent Title (English): | International Journal of Molecular Sciences |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of first Publication: | 2017/09/19 |
| Release Date: | 2022/11/25 |
| Tag: | CAP; apoptosis; cancer; osteosarcoma; plasma medicine; plasma oncology |
| GND Keyword: | - |
| Volume: | 18 |
| Issue: | 9 |
| Page Number: | 13 |
| Faculties: | Universitätsmedizin / Klinik und Poliklinik für Chirurgie Abt. für Unfall- und Wiederherstellungschirurgie |
| Licence (German): |  Creative Commons - Namensnennung |