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Realizing 1,1-Dehydration of Secondary Alcohols to Carbenes: Pyrrolidin-2-ols as a Source of Cyclic (Alkyl)(Amino)Carbenes
- Herein we report secondary pyrrolidin-2-ols as a source of cyclic (alkyl)(amino)carbenes (CAAC) for the synthesis of CAAC-CuI-complexes and cyclic thiones when reacted with CuI-salts and elemental sulfur, respectively, under reductive elimination of water from the carbon(IV)-center. This result demonstrates a convenient and facile access to CAAC-based CuI-salts, which are well known catalysts for different organic transformations. It further establishes secondary alcohols to be a viable source of carbenes—realizing after 185 years Dumas’ dream who tried to prepare the parent carbene (CH2) by 1,1-dehydration of methanol. Addressed is also the reactivity of water towards CAACs, which proceeds through an oxidative addition of the O−H bond to the carbon(II)-center. This emphasizes the ability of carbon-compounds to mimic the reactivity of transition-metal complexes: reversible oxidative addition and reductive elimination of the O−H bond to/from the C(II)/C(IV)-centre.
Author: | Ayan Das, Benedict J. Elvers, Mithilesh Kumar Nayak, Nicolas Chrysochos, Srinivas Anga, Amar Kumar, D. Krishna Rao, Tharangattu N. Narayanan, Carola Schulzke, Cem B. Yildiz, Anukul Jana |
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URN: | urn:nbn:de:gbv:9-opus-107052 |
DOI: | https://doi.org/10.1002/anie.202202637 |
ISSN: | 1521-3773 |
Parent Title (English): | Angewandte Chemie International Edition |
Publisher: | Wiley |
Place of publication: | Hoboken, NJ |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2022/04/01 |
Date of first Publication: | 2022/07/11 |
Release Date: | 2024/02/22 |
Tag: | 1,1-Dehydration; Carbenes; Dehydrogenation; Elimination; Hydrated Carbenes |
Volume: | 61 |
Issue: | 28 |
Article Number: | e202202637 |
Page Number: | 8 |
Faculties: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie |
Collections: | weitere DFG-förderfähige Artikel |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 4.0 International |