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Acute COPD exacerbation treatment with noninvasive ventilation
- The establishment of a guideline for long-term noninvasive ventilation treatment (LTH-NIV) of acute hypercapnic exacerbations of chronic obstructive pulmonary disease (AECOPD) requiring acute ventilation has proven elusive. Most studies thus far have shown no mortality benefit of long-term noninvasive ventilation treatment. Using retrospective analysis of the data of our patients (n = 143) recruited from 2012 to 2019, we aimed to compare patients discharged with and without long-term noninvasive ventilation. The follow-up results showed no significant difference (p = 0.233) between the groups [LTH-NIV (n = 83); non-NIV (n = 60)] regarding readmission due to clinical worsening. However, the first- and second-year survival rates were 82% and 72%, respectively, in the LTH-NIV group and significantly different (p = 0.023) from 67 and 55% in the non-NIV group. The statistical models showed a significant mortality risk for the non-NIV group, with a hazard ratio (HR) of 2.82 (1.31; 6.03). To the best of our knowledge, this is the first study to demonstrate the mortality benefit of long-term NIV therapy for patients with AECOPD under real-world conditions.
Author: | Ralf EwertORCiD, Alexander Heine, Anne Obst, Karoline Koerner, Veit Hustig-Kittler, Michael Boesche, Mohamed Elhadad, Beate Stubbe, Michael Westhoff |
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URN: | urn:nbn:de:gbv:9-opus-105935 |
DOI: | https://doi.org/10.1038/s41598-023-33871-z |
ISSN: | 2045-2322 |
Parent Title (English): | Scientific Reports |
Publisher: | Nature Publishing Group |
Place of publication: | London |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2023/04/21 |
Release Date: | 2024/02/01 |
Volume: | 13 |
Article Number: | 6586 |
Page Number: | 10 |
Faculties: | Universitätsmedizin / Kliniken und Polikliniken für Innere Medizin |
Collections: | Artikel aus DFG-gefördertem Publikationsfonds |
Licence (German): | Creative Commons - Namensnennung |