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Comorbid Depression and Diabetes Are Associated with Impaired Health-Related Quality of Life in Chronic Kidney Disease Patients
- Given the increasing prevalence of chronic kidney disease (CKD) and its impact on health care, it is important to better understand the multiple factors influencing health-related quality of life (HRQOL), particularly since they have been shown to affect CKD outcomes. Determinants of HRQOL as measured by the validated Kidney Disease Quality of Life questionnaire (KDQOL) and the Patient Health Questionnaire depression screener (PHQ-9) were assessed in a routine CKD patient sample, the Greifswald Approach to Individualized Medicine (GANI_MED) renal cohort (N = 160), including a wide range of self-reported data, sociodemographic and laboratory measures. Compared to the general population, CKD patients had lower HRQOL indices. Dialysis was associated with (1) low levels of physical functioning, (2) increased impairments by symptoms and problems, and (3) more effects and burden of kidney disease. HRQOL is seriously affected in CKD patients. However, impairments were found irrespective of eGFR decline and albuminuria. Rather, the comorbid conditions of depression and diabetes predicted a lower HRQOL (physical component score). Further studies should address whether recognizing and treating depression may not only improve HRQOL but also promote survival and lower hospitalization rates of CKD patients.
Author: | Janine Wirkner, Matthias Scheuch, Thomas Dabers, Sabrina Freiin von Rheinbaben, Beate Fiene, Simone Aymanns, Karlhans Endlich, Nicole Endlich, Uwe Lendeckel, Rainer Rettig, Hans Jörgen GrabeORCiD, Sylvia Stracke |
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URN: | urn:nbn:de:gbv:9-opus-65358 |
DOI: | https://doi.org/10.3390/jcm11164671 |
ISSN: | 2077-0383 |
Parent Title (English): | Journal of Clinical Medicine |
Publisher: | MDPI |
Place of publication: | Basel |
Editor: | Alberto Martínez-Castelao |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2022/08/10 |
Release Date: | 2022/11/21 |
Tag: | chronic kidney disease; depression; diabetes; dialysis; eGFR; health-related quality of life |
GND Keyword: | - |
Volume: | 11 |
Issue: | 16 |
Page Number: | 12 |
Faculties: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Psychologie |
Collections: | Artikel aus DFG-gefördertem Publikationsfonds |
Licence (German): | Creative Commons - Namensnennung |