Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-61561
Variability of Thyroid Measurements from Ultrasound and Laboratory in a Repeated Measurements Study
- Background: Variability of measurements in medical research can be due to different sources. Quantification of measurement errors facilitates probabilistic sensitivity analyses in future research to minimize potential bias in epidemiological studies. We aimed to investigate the variation of thyroid-related outcomes derived from ultrasound (US) and laboratory analyses in a repeated measurements study. Subjects and Methods: Twenty-five volunteers (13 females, 12 males) aged 22–70 years were examined once a month over 1 year. US measurements included thyroid volume, goiter, and thyroid nodules. Laboratory measurements included urinary iodine concentrations and serum levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), and thyroglobulin. Variations in continuous thyroid markers were assessed as coefficient of variation (CV) defined as mean of the individual CVs with bootstrapped confidence intervals and as intraclass correlation coefficients (ICCs). Variations in dichotomous thyroid markers were assessed by Cohen’s kappa. Results: CV was highest for urinary iodine concentrations (56.9%), followed by TSH (27.2%), thyroglobulin (18.2%), thyroid volume (10.5%), fT3 (8.1%), and fT4 (6.3%). The ICC was lowest for urinary iodine concentrations (0.42), followed by fT3 (0.55), TSH (0.64), fT4 (0.72), thyroid volume (0.87), and thyroglobulin (0.90). Cohen’s kappa values for the presence of goiter or thyroid nodules were 0.64 and 0.70, respectively. Conclusion: Our study provides measures of variation for thyroid outcomes, which can be used for probabilistic sensitivity analyses of epidemiological data. The low intraindividual variation of serum thyroglobulin in comparison to urinary iodine concentrations emphasizes the potential of thyroglobulin as marker for the iodine status of populations.
Author: | Till IttermannORCiD, Adrian Richter, Martin Junge, Matthias NauckORCiD, Astrid Petersmann, Clemens Jürgens, Harald Below, Carsten Oliver Schmidt, Henry VölzkeORCiD |
---|---|
URN: | urn:nbn:de:gbv:9-opus-61561 |
DOI: | https://doi.org/10.1159/000507018 |
ISSN: | 2235-0640 |
ISSN: | 2235-0802 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/33981618 |
Parent Title (English): | European Thyroid Journal |
Publisher: | S. Karger AG |
Place of publication: | Basel, Switzerland |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2020/05/05 |
Release Date: | 2022/11/30 |
Tag: | Iodine; Measurement error; Thyroglobulin; Thyroid; Thyroid imaging; Thyroid-stimulating hormone; Variability |
GND Keyword: | - |
Volume: | 10 |
Issue: | 2 |
First Page: | 140 |
Last Page: | 149 |
Faculties: | Universitätsmedizin / Institut für Community Medicine |
Licence (German): | Creative Commons - Namensnennung |