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Course of disease and risk factors for hospitalization in outpatients with a SARS-CoV-2 infection
- We analyzed symptoms and comorbidities as predictors of hospitalization in 710 outpatients in North-East Germany with PCR-confirmed SARS-CoV-2 infection. During the first 3 days of infection, commonly reported symptoms were fatigue (71.8%), arthralgia/myalgia (56.8%), headache (55.1%), and dry cough (51.8%). Loss of smell (anosmia), loss of taste (ageusia), dyspnea, and productive cough were reported with an onset of 4 days. Anosmia or ageusia were reported by only 18% of the participants at day one, but up to 49% between days 7 and 9. Not all participants who reported ageusia also reported anosmia. Individuals suffering from ageusia without anosmia were at highest risk of hospitalization (OR 6.8, 95% CI 2.5–18.1). They also experienced more commonly dyspnea and nausea (OR of 3.0, 2.9, respectively) suggesting pathophysiological connections between these symptoms. Other symptoms significantly associated with increased risk of hospitalization were dyspnea, vomiting, and fever. Among basic parameters and comorbidities, age > 60 years, COPD, prior stroke, diabetes, kidney and cardiac diseases were also associated with increased risk of hospitalization. In conclusion, due to the delayed onset, ageusia and anosmia may be of limited use in differential diagnosis of SARS-CoV-2. However, differentiation between ageusia and anosmia may be useful for evaluating risk for hospitalization.
Author: | Eik Schäfer, Christian Scheer, Karen Saljé, Anja Fritz, Thomas Kohlmann, Nils-Olaf Hübner, Matthias Napp, Lizon Fiedler-Lacombe, Dana Stahl, Bernhard Rauch, Matthias NauckORCiD, Uwe VölkerORCiD, Stephan Felix, Guglielmo Lucchese, Agnes FlöelORCiD, Stefan Engeli, Wolfgang HoffmannORCiD, Klaus Hahnenkamp, Mladen V. TzvetkovORCiD |
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URN: | urn:nbn:de:gbv:9-opus-104891 |
DOI: | https://doi.org/10.1038/s41598-022-11103-0 |
ISSN: | 2045-2322 |
Parent Title (English): | Scientific Reports |
Publisher: | Nature Publishing Group |
Place of publication: | London |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2022/05/04 |
Release Date: | 2024/01/19 |
Volume: | 12 |
Article Number: | 7249 |
Page Number: | 12 |
Faculties: | Universitätsmedizin / Institut für Pharmakologie |
Collections: | Artikel aus DFG-gefördertem Publikationsfonds |
Licence (German): | Creative Commons - Namensnennung |